Research output per year
Research output per year
Personal profile
Personal profile
After completing his MD degree, Dr. Gustafsson was appointed Associate Professor of Chemistry at the Karolinska Institute in 1971, and was made full professor in 1976. In 1979, he was named Professor of Medical Nutrition and Chairman of the Department of Medical Nutrition at Huddinge University Hospital at the Karolinska Institute. In 1987, together with Dr. John Baxter, founded Karo Bio, a campus-situated biotechnology company with approximately 80 employees, to develop and commercialize products to treat human diseases such as obesity, diabetes, metabolic syndrome, and breast cancer. He is a member of the U.S. National Academy of Sciences, has published more than 1,300 peer-reviewed journal articles, and has trained over 200 Ph.D. students, post doctoral fellows, and visiting scientists. He was appointed Director of The Center for Nuclear Receptors and Cell Signaling at the University of Houston, with a joint appointment at Houston Methodist Research Institute, in 2009.
Research interests
Nuclear receptors are proteins embedded in the cell nucleus that bind hormones and influence gene expression. Dr. Gustafsson and his research team discovered a novel nuclear receptor (estrogen receptor beta, ER-β) that plays a role in several human diseases including breast, ovarian, and prostate cancer. The goal of his research is to develop small molecule modulators of this and other hormone receptors to treat human disease.
Education/Academic qualification
PhD, Division of Clinical Chemistry, Department of Laboratory Medicine Karolinska Institutet
External positions
University of Houston
Free-text keywords
- Nuclear receptors
- Estrogen receptors
- Breast cancer
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Research output
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25 years of ERβ: A personal journey
Warner, M., Fan, X., Strom, A., Wu, W. & Gustafsson, J. Å., Jan 2022, In: Journal of Molecular Endocrinology. 68, 1, p. R1-R9Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway
Marroqui, L., Martinez-Pinna, J., Castellano-Muñoz, M., dos Santos, R. S., Medina-Gali, R. M., Soriano, S., Quesada, I., Gustafsson, J. A., Encinar, J. A. & Nadal, A., Feb 2021, In: Chemosphere. 265, 129051.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Drivers and suppressors of triple-negative breast cancer
Wu, W., Warner, M., Wang, L., He, W. W., Zhao, R., Guan, X., Botero, C., Huang, B., Ion, C., Coombes, C. & Gustafsson, J. A., Aug 17 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 33, e2104162118.Research output: Contribution to journal › Article › peer-review
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Estrogen receptor beta and neural development
Nalvarte, I., Varshney, M., Inzunza, J. & Gustafsson, J. Å., Jan 2021, Hormones and Stem Cells. Litwack, G. (ed.). Academic Press, p. 313-326 14 p. (Vitamins and Hormones; vol. 116).Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Scopus citations -
Estrogen receptor β and treatment with a phytoestrogen are associated with inhibition of nuclear translocation of EGFR in the prostate
Wu, W. F., Wang, L., Spetsieris, N., Boukovala, M., Efstathiou, E., Brössner, C., Warner, M. & Gustafsson, J. A., Mar 30 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 13, 2011269118.Research output: Contribution to journal › Article › peer-review
2 Scopus citations