Research outputs

  1. 2019
  2. Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway

    Do, H., Makthal, N., VanderWal, A. R., Saavedra, M. O., Olsen, R. J., Musser, J. M. & Kumaraswami, M., Jun 13 2019, In : Nature Communications. 10, 1, 2586.

    Research output: Contribution to journalArticle

  3. Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis

    Kachroo, P., Eraso, J. M., Beres, S. B., Olsen, R. J., Zhu, L., Nasser, W., Bernard, P. E., Cantu, C. C., Saavedra, M. O., Arredondo, M. J., Strope, B., Do, H., Kumaraswami, M., Vuopio, J., Gröndahl-Yli-Hannuksela, K., Kristinsson, K. G., Gottfredsson, M., Pesonen, M., Pensar, J., Davenport, E. R. & 11 othersClark, A. G., Corander, J., Caugant, D. A., Gaini, S., Magnussen, M. D., Kubiak, S. L., Nguyen, H. A. T., Long, S. W., Porter, A. R., DeLeo, F. R. & Musser, J. M., Mar 1 2019, In : Nature Genetics. 51, 3, p. 548-559 12 p.

    Research output: Contribution to journalArticle

  4. Gene fitness landscape of group A streptococcus during necrotizing myositis

    Zhu, L., Olsen, R. J., Beres, S. B., Eraso, J. M., Saavedra, M. O., Kubiak, S. L., Cantu, C. C., Jenkins, L., Charbonneau, A. R. L., Waller, A. S. & Musser, J. M., Feb 1 2019, In : The Journal of clinical investigation. 129, 2, p. 887-901 15 p.

    Research output: Contribution to journalArticle

  5. 2018
  6. RocA Has Serotype-Specific Gene Regulatory and Pathogenesis Activities in Serotype M28 Group A Streptococcus

    Bernard, P. E., Kachroo, P., Zhu, L., Beres, S. B., Eraso, J. M., Kajani, Z., Long, S. W., Musser, J. M. & Olsen, R. J., Nov 1 2018, In : Infection and immunity. 86, 11, e00467-18.

    Research output: Contribution to journalArticle

  7. Phenotypic Variation in the Group A Streptococcus Due to Natural Mutation of the Accessory Protein-Encoding Gene rocA

    Sarkar, P., Danger, J. L., Jain, I., Meadows, L. A., Beam, C., Medicielo, J., Burgess, C., Musser, J. M. & Sumby, P., Oct 17 2018, In : mSphere. 3, 5

    Research output: Contribution to journalArticle

  8. Postpartum Group A Streptococcus Case Series: Reach Out to Infection Prevention!

    Alexander, A. J., Myers, C., Beres, S. B., Olsen, R. J., Musser, J. M. & Mangino, J. E., Jul 2018, In : Open Forum Infectious Diseases. 5, 7, p. ofy159

    Research output: Contribution to journalArticle

  9. Signaling by a conserved quorum sensing pathway contributes to growth ex vivo and oropharyngeal colonization of human pathogen group A streptococcus

    Makthal, N., Do, H., VanderWal, A. R., Olsen, R. J., Musser, J. M. & Kumaraswami, M., May 1 2018, In : Infection and Immunity. 86, 5, e00169-18.

    Research output: Contribution to journalArticle

  10. Developing an in silico minimum inhibitory concentration panel test for Klebsiella pneumonia

    Nguyen, M., Brettin, T., Long, S. W., Musser, J. M., Olsen, R. J., Olson, R., Shukla, M., Stevens, R. L., Xia, F., Yoo, H. & Davis, J. J., Jan 11 2018, In : Scientific Reports. 8, 1, 421.

    Research output: Contribution to journalArticle

  11. 2017
  12. Genome sequence analysis of emm89 Streptococcus pyogenes strains causing infections in Scotland, 2010–2016

    Beres, S. B., Olsen, R. J., Saavedra, M. O., Ure, R., Reynolds, A., Lindsay, D. S. J., Smith, A. J. & Musser, J. M., Dec 1 2017, In : Journal of Medical Microbiology. 66, 12, p. 1765-1773 9 p., 000622.

    Research output: Contribution to journalArticle

  13. Novel genes required for the fitness of Streptococcus pyogenes in human saliva

    Zhu, L., Charbonneau, A. R. L., Waller, A. S., Olsen, R. J., Beres, S. B. & Musser, J. M., Nov 1 2017, In : mSphere. 2, 6, e00460-17.

    Research output: Contribution to journalArticle

  14. Leaderless secreted peptide signaling molecule alters global gene expression and increases virulence of a human bacterial pathogen

    Do, H., Makthal, N., VanderWal, A. R., Rettel, M., Savitski, M. M., Peschek, N., Papenfort, K., Olsen, R. J., Musser, J. M. & Kumaraswami, M., Sep 18 2017, In : Proceedings of the National Academy of Sciences.

    Research output: Contribution to journalArticle

  15. Increased pilus production conferred by a naturally occurring mutation alters hostpathogen interaction in favor of carriage in Streptococcus pyogenes

    Flores, A. R., Olsen, R. J., Cantu, C., Pallister, K. B., Guerra, F. E., Voyich, J. M. & Musser, J. M., May 1 2017, In : Infection and Immunity. 85, 5, e00949-16.

    Research output: Contribution to journalArticle

  16. Opacification domain of serum opacity factor inhibits beta-hemolysis and contributes to virulence of Streptococcus pyogenes

    Zhu, L., Olsen, R. J. & Musser, J. M., Mar 1 2017, In : mSphere. 2, 2, e00147-17.

    Research output: Contribution to journalArticle

  17. Rapid emergence of a new clone impacts the population at risk and increases the incidence of type emm89 group A Streptococcus invasive disease

    Teatero, S., Coleman, B. L., Beres, S. B., Olsen, R. J., Kandel, C., Reynolds, O., Athey, T. B. T., Musser, J. M., McGeer, A. & Fittipaldi, N., Mar 1 2017, In : Open Forum Infectious Diseases. 4, 2, ofx042.

    Research output: Contribution to journalArticle

  18. Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis

    Skwark, M. J., Croucher, N. J., Puranen, S., Chewapreecha, C., Pesonen, M., Xu, Y. Y., Turner, P., Harris, S. R., Beres, S. B., Musser, J. M., Parkhill, J., Bentley, S. D., Aurell, E. & Corander, J., Feb 2017, In : PLoS Genetics. 13, 2, p. e1006508

    Research output: Contribution to journalArticle

  19. Contribution of Secreted NADase and Streptolysin O to the Pathogenesis of Epidemic Serotype M1 Streptococcus pyogenes Infections

    Zhu, L., Olsen, R. J., Lee, J. D., Porter, A. R., DeLeo, F. R. & Musser, J. M., 2017, (Accepted/In press) In : American Journal of Pathology.

    Research output: Contribution to journalArticle

  20. Deletion of atoR from Streptococcus pyogenes Results in hypervirulence in a mouse model of sepsis and is LuxS independent

    Sitkiewicz, I. & Musser, J. M., 2017, In : Polish Journal of Microbiology. 66, 1, p. 17-24 8 p.

    Research output: Contribution to journalArticle

  21. 2016
  22. Genomic Characteristics Behind the Spread of Bacteremic Group A Streptococcus Type emm89 in Finland, 2004-2014

    Latronico, F., Nasser, W., Puhakainen, K., Ollgren, J., Hyyryläinen, H-L., Beres, S. B., Lyytikäinen, O., Jalava, J., Musser, J. M. & Vuopio, J., Dec 15 2016, In : Journal of Infectious Diseases. 214, 12, p. 1987-1995 9 p.

    Research output: Contribution to journalArticle

  23. Genomic Landscape of Intrahost Variation in Group A Streptococcus: Repeated and Abundant Mutational Inactivation of the fabT Gene Encoding a Regulator of Fatty Acid Synthesis

    Eraso, J. M., Olsen, R. J., Beres, S. B., Kachroo, P., Porter, A. R., Nasser, W., Bernard, P. E., DeLeo, F. R. & Musser, J. M., Dec 2016, In : Infection and Immunity. 84, 12, p. 3268-3281 14 p.

    Research output: Contribution to journalArticle

  24. Unique footprint in the scl1.3 locus affects adhesion and biofilm formation of the invasive M3-Type Group A Streptococcus

    Bachert, B. A., Choi, S. J., LaSala, P. R., Harper, T. I., McNitt, D. H., Boehm, D. T., Caswell, C. C., Ciborowski, P., Keene, D. R., Flores, A. R., Musser, J. M., Squeglia, F., Marasco, D., Berisio, R. & Lukomski, S., Aug 31 2016, In : Frontiers in Cellular and Infection Microbiology. 6, AUG, 90.

    Research output: Contribution to journalArticle

  25. Intergenic variable-number tandem-repeat polymorphism upstream of rocA alters toxin production and enhances virulence in Streptococcus pyogenes

    Zhu, L., Olsen, R. J., Horstmann, N., Shelburne, S. A., Fan, J., Hu, T. & Musser, J. M., May 2 2016, In : Infection and Immunity. 84, 7, p. 2086-2093 8 p.

    Research output: Contribution to journalArticle

  26. Integrating rapid diagnostics and antimicrobial stewardship in two community hospitals improved process measures and antibiotic adjustment time

    Lockwood, A. M., Perez, K. K., Musick, W. L., Ikwuagwu, J. O., Attia, E., Fasoranti, O. O., Cernoch, P. L., Olsen, R. J. & Musser, J. M., Apr 1 2016, In : Infection Control and Hospital Epidemiology. 37, 4, p. 425-432 8 p.

    Research output: Contribution to journalArticle

  27. Structural and functional analysis of RopB: A major virulence regulator in Streptococcus pyogenes

    Makthal, N., Gavagan, M., Do, H., Olsen, R. J., Musser, J. M. & Kumaraswami, M., Mar 1 2016, In : Molecular Microbiology. 99, 6, p. 1119-1133 15 p.

    Research output: Contribution to journalArticle

  28. Transcriptome remodeling contributes to epidemic disease caused by the human pathogen Streptococcus pyogenes

    Beres, S. B., Kachroo, P., Nasser, W., Olsen, R. J., Zhu, L., Flores, A. R., de la Riva, I., Paez-Mayorga, J., Jimenez, F. E., Cantu, C., Vuopio, J., Jalava, J., Kristinsson, K. G., Gottfredsson, M., Corander, J., Fittipaldi, N., Di Luca, M. C., Petrelli, D., Vitali, L. A., Raiford, A. & 2 othersJenkins, L. & Musser, J. M., 2016, In : mBio. 7, 3, e00403-16.

    Research output: Contribution to journalArticle

  29. 2015
  30. A molecular trigger for intercontinental epidemics of group A Streptococcus

    Zhu, L., Olsen, R. J., Nasser, W., Beres, S. B., Vuopio, J., Kristinsson, K. G., Gottfredsson, M., Porter, A. R., DeLeo, F. R. & Musser, J. M., Sep 1 2015, In : The Journal of clinical investigation. 125, 9, p. 3545-3559 15 p.

    Research output: Contribution to journalArticle

  31. Adhesin competence repressor (AdcR) from Streptococcus pyogenes controls adaptive responses to zinc limitation and contributes to virulence

    Sanson, M., Makthal, N., Flores, A. R., Olsen, R. J., Musser, J. M. & Kumaraswami, M., Sep 1 2015, In : Nucleic acids research. 43, 1, p. 418-432 15 p.

    Research output: Contribution to journalArticle

  32. Molecular pathogenesis lessons from the world of infectious diseases research

    Musser, J. M. & Deleo, F. R., Jun 1 2015, In : American Journal of Pathology. 185, 6, p. 1502-1504 3 p.

    Research output: Contribution to journalArticle

  33. Haemagglutinin mutations and glycosylation changes shaped the 2012/13 influenza A(H3N2) epidemic, Houston, Texas

    Stucker, K. M., Schobel, S. A., Olsen, R. J., Hodges, H. L., Lin, X., Halpin, R. A., Fedorova, N., Stockwell, T. B., Tovchigrechko, A., Das, S. R., Wentworth, D. E. & Musser, J. M., May 7 2015, In : Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 20, 18

    Research output: Contribution to journalArticle

  34. Comparative whole genome sequencing of community-associated methicillin-resistant Staphylococcus aureus sequence type 8 from primary care clinics in a Texas community

    Lee, G. C., Long, S. W., Musser, J. M., Beres, S. B., Olsen, R. J., Dallas, S. D., Nunez, Y. O. & Frei, C. R., Feb 1 2015, In : Pharmacotherapy. 35, 2, p. 220-228 9 p.

    Research output: Contribution to journalArticle

  35. Improving positive blood culture removal time significantly decreases total processing time

    Salazar, E., Divatia, M. K., Cernoch, P. L., Olsen, R. J., Long, S. W., Land, G. A., Davis, J. R. & Musser, J. M., Feb 1 2015, In : Archives of Pathology and Laboratory Medicine. 139, 2, p. 199-203 5 p.

    Research output: Contribution to journalArticle

  36. A single amino acid replacement in the sensor kinase lias contributes to a carrier phenotype in group a streptococcus

    Flores, A. R., Jewell, B. E., Yelamanchili, D., Olsen, R. J. & Musser, J. M., 2015, In : Infection and Immunity. 83, 11, p. 4237-4246 10 p.

    Research output: Contribution to journalArticle

  37. Natural variant of collagen-like protein a in serotype M3 group a Streptococcus increases adherence and decreases invasive potential

    Flores, A. R., Jewell, B. E., Versalovic, E. M., Olsen, R. J., Bachert, B. A., Lukomski, S. & Musser, J. M., 2015, In : Infection and Immunity. 83, 3, p. 1122-1129 8 p.

    Research output: Contribution to journalArticle

  38. Phosphorylation events in the multiple gene regulator of group A Streptococcus significantly influence global gene expression and virulence

    Sanson, M., Makthal, N., Gavagan, M., Cantu, C., Olsen, R. J., Musser, J. M. & Kumaraswami, M., 2015, In : Infection and Immunity. 83, 6, p. 2382-2395 14 p.

    Research output: Contribution to journalArticle

  39. The majority of 9,729 group A streptococcus strains causing disease secrete SpeB cysteine protease: Pathogenesis implications

    Olsen, R. J., Raghuram, A., Cantu, C., Hartman, M. H., Jimenez, F. E., Lee, S., Ngo, A., Rice, K. A., Saddington, D., Spillman, H., Valson, C., Flores, A. R., Beres, S. B., Long, S. W., Nasser, W. & Musser, J. M., 2015, In : Infection and Immunity. 83, 12, p. 4750-4758 9 p.

    Research output: Contribution to journalArticle

  40. 2014
  41. PBP2a mutations causing high-level ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates

    Long, S. W., Olsen, R. J., Mehta, S. C., Palzkill, T., Cernoch, P. L., Perez, K. K., Musick, W. L., Rosato, A. E. & Musser, J. M., Nov 1 2014, In : Antimicrobial agents and chemotherapy. 58, 11, p. 6668-6674 7 p.

    Research output: Contribution to journalArticle

  42. Precisely modulated pathogenicity island interference with late phage gene transcription

    Ram, G., Chen, J., Ross, H. F., Novick, R. P. & Musser, J. M., Oct 7 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 40, p. 14536-14541 6 p.

    Research output: Contribution to journalArticle

  43. Molecular characterization of an invasive phenotype of group a streptococcus arising during human infection using whole genome sequencing of multiple isolates from the same patient

    Flores, A. R., Sahasrabhojane, P., Saldaña, M., Galloway-Peña, J., Olsen, R. J., Musser, J. M. & Shelburne, S. A., May 15 2014, In : Journal of Infectious Diseases. 209, 10, p. 1520-1523 4 p.

    Research output: Contribution to journalArticle

  44. Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences

    Nasser, W., Beres, S. B., Olsen, R. J., Dean, M. A., Rice, K. A., Long, S. W., Kristinsson, K. G., Gottfredsson, M., Vuopio, J., Raisanen, K., Caugant, D. A., Steinbakk, M., Low, D. E., McGeer, A., Darenberg, J., Henriques-Normark, B., Van Beneden, C. A., Hoffmann, S. & Musser, J. M., Apr 29 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 17

    Research output: Contribution to journalArticle

  45. Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae

    DeLeo, F. R., Chen, L., Porcella, S. F., Martens, C. A., Kobayashi, S. D., Porter, A. R., Chavda, K. D., Jacobs, M. R., Mathema, B., Olsen, R. J., Bonomo, R. A., Musser, J. M. & Kreiswirth, B. N., Apr 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 13, p. 4988-4993 6 p.

    Research output: Contribution to journalArticle

  46. Mycobacterium tuberculosis bacteraemia: Experience from a non-endemic urban centre

    El Sahly, H. M., Teeter, L. D., Musser, J. M. & Graviss, E. A., Mar 1 2014, In : Clinical Microbiology and Infection. 20, 3, p. 263-268 6 p.

    Research output: Contribution to journalArticle

  47. Asymptomatic carriage of group A streptococcus is associated with elimination of capsule production

    Flores, A. R., Jewell, B. E., Olsen, R. J., Shelburne, S. A., Fittipaldi, N., Beres, S. B. & Musser, J. M., Jan 1 2014, In : Infection and Immunity. 82, 9, p. 3958-3967 10 p.

    Research output: Contribution to journalArticle

  48. Clinical laboratory response to a mock outbreak of invasive bacterial infections: A preparedness study

    Olsen, R. J., Fittipaldi, N., Kachroo, P., Sanson, M. A., Long, S. W., Como-Sabetti, K. J., Valson, C., Cantu, C., Lynfield, R., Van Beneden, C., Beres, S. B. & Musser, J. M., Jan 1 2014, In : Journal of Clinical Microbiology. 52, 12, p. 4210-4216 7 p.

    Research output: Contribution to journalArticle

  49. Identification of point mutations in clinical staphylococcus aureus strains that produce small-colony variants auxotrophic for menadione

    Dean, M. A., Olsen, R. J., Long, S. W., Rosato, A. E. & Musser, J. M., Jan 1 2014, In : Infection and Immunity. 82, 4, p. 1600-1605 6 p.

    Research output: Contribution to journalArticle

  50. Natural disruption of two regulatory networks in serotype M3 Group A Streptococcus isolates contributes to the virulence factor profile of this hypervirulent serotype

    Cao, T. N., Liu, Z., Cao, T. H., Pflughoeft, K. J., Treviño, J., Danger, J. L., Beres, S. B., Musser, J. M. & Sumby, P., Jan 1 2014, In : Infection and Immunity. 82, 5, p. 1744-1754 11 p.

    Research output: Contribution to journalArticle

  51. Spread of virulent group a streptococcus type emm59 from Montana to Wyoming, USA

    Brown, C. C., Olsen, R. J., Fittipaldi, N., Morman, M. L., Fort, P. L., Neuwirth, R., Majeed, M., Woodward, W. B. & Musser, J. M., Jan 1 2014, In : Emerging infectious diseases. 20, 4, p. 679-681 3 p.

    Research output: Contribution to journalArticle

  52. A naturally occurring single amino acid replacement in multiple gene regulator of group a streptococcus significantly increases virulence

    Sanson, M., O'Neill, B. E., Kachroo, P., Anderson, J. R., Flores, A. R., Valson, C., Cantu, C. C., Makthal, N., Karmonik, C., Fittipaldi, N., Kumaraswami, M., Musser, J. M. & Olsen, R. J., 2014, In : American Journal of Pathology. 185, 2, p. 462-471 10 p.

    Research output: Contribution to journalArticle

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ID: 2282848