Huw Summers, PhD

  • 1855 Citations
  • 22 h-Index
1991 …2020

Research output per year

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Personal profile

Personal profile

Dr. Huw Summers is a professor in nanotechnology for health in the College of Engineering at Swansea University in Wales. Dr. Summers has extensive experience in metrologies for cell analysis and the development of nanoparticle-based diagnostics and therapeutics. He has more than 80 peer-reviewed publications in prestigious journals including Applied Physics Letters and Nature Nanotechnology and is supported by several European Union research grants.

As an Full Affiliate Member of Houston Methodist Research Institute, Dr. Summers collaborates with the nanomedicine department to develop physics and engineering approaches for cell analysis. Dr. Summers is also a mentor for the formal joint graduate training program between the Houston Methodist Academy and Swansea University.

Research interests

In the field of nanomedicine, Dr. Summers’ group is one of only a handful, developing quantitative, statistical assays for the assessment of nanoparticle dose in proliferating cell populations. Dr. Summers’ research focuses on two areas: metrologies for cell analysis (cytometry) and the development of nanoparticle-based diagnostics and therapeutics (nanomedicine).

The goal of this work is to apply physics and engineering approaches to cell population analysis, e.g. systems analysis of cell cycle progression or statistical mechanics on nanoparticle-cell interactions. Computational and statistical analyses are applied to large cell populations (>106) with the enabling technology being high throughput, high content cytometry (microscope and flow system based) and the core aim to understand and quantify cell heterogeneity.

His research program exploits the customizability of micro and nano-engineered structures to provide novel optical analysis and manipulation of living cells. For example, using fluorescent nanocrystals (quantum dots) as intra-cellular markers cell populations allows tracking over multiple generations of cell division, and the evolution of different lineages can then be analyzed by their unique spectral signatures.

Education/Academic qualification

Laser Physics, PhD, Cardiff University

Optoelectronics, Postdoctoral Fellowship, University of Bath

Free-text keywords

  • Nanomedicine
  • Optical techniques for biomedicine
  • Cytometry
  • Nanoparticle fluorophores

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Research Output

Activity mapping of children in play using multivariate analysis of movement events

Rocha, J. N., Barnes, C. M., Rees, P., Clark, C. T., Stratton, G. & Summers, H. D., Jan 1 2020, In : Medicine and science in sports and exercise. 52, 1, p. 259-266 8 p.

Research output: Contribution to journalArticle

  • 2 Scopus citations

    Design of experiment (DoE)-driven in vitro and in vivo uptake studies of exosomes for pancreatic cancer delivery enabled by copper-free click chemistry-based labelling

    Xu, L., Faruqu, F. N., Liam-or, R., Abu Abed, O., Li, D., Venner, K., Errington, R. J., Summers, H., Wang, J. T. W. & Al-Jamal, K. T., Jun 19 2020, In : Journal of Extracellular Vesicles. 9, 1, 1779458.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Diffusion Mapping of Eosinophil-Activation State

    Piasecka, J., Thornton, C. A., Rees, P. & Summers, H. D., Mar 1 2020, In : Cytometry Part A. 97, 3, p. 253-258 6 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Image-Based Cell Profiling Enables Quantitative Tissue Microscopy in Gastroenterology

    Wills, J. W., Robertson, J., Summers, H., Miniter, M., Barnes, C., Hewitt, R. E., Keita, Å. V., Söderholm, J. D., Rees, P. & Powell, J. J., Jan 1 2020, In : Cytometry Part A.

    Research output: Contribution to journalArticle

  • Label-Free Leukemia Monitoring by Computer Vision

    Doan, M., Case, M., Masic, D., Hennig, H., McQuin, C., Caicedo, J., Singh, S., Goodman, A., Wolkenhauer, O., Summers, H. D., Jamieson, D., Delft, F. V., Filby, A., Carpenter, A. E., Rees, P. & Irving, J., Apr 1 2020, In : Cytometry Part A. 97, 4, p. 407-414 8 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations