Projects per year
Personal profile
Personal profile
Dr. Zhao joined the Houston Methodist Research Institute in 2008. She is a member of the American Association for Cancer Research and the International Association for Biological and Medical Research. She has been published in prestigious journals including the Journal of Neurosurgery.
Research interests
Dr. Zhao's research uses systems biology approaches to study and combat brain metastasis of breast cancer. Her projects integrate "dry lab" computational modeling with "wet lab" experimental testing to discover effective new drug treatment strategies and explore personalized drug combinations. She is using a systems biology strategy in combination with repositioned FDA-approved drugs that can breach the blood-brain barrier to target the signaling network of primary breast tumors that are in the process of metastasizing to the brain.
Education/Academic qualification
Biological Sciences, Postdoctoral Fellowship, Brigham and Women’s Hospital, Harvard University, Boston, MA
Neurology, PhD, Shanghai Medical College of Fudan University
Molecular Imaging & Systems Biology, Postdoctoral Fellowship, The Methodist Hospital
Free-text keywords
- Breast cancer
- Brain metastasis
- Systems biology
- Computational modeling
- Imaging
Research Area Keywords
- Cancer
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Projects
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Systematic identification of astrocyte-tumor crosstalk regulating brain metastatic tumors
Wong, S. T., Zhao, H. & Sheng, J.
8/1/20 → 1/31/21
Project: Federal Funding Agencies
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Systematic identification of astrocyte-tumor crosstalk regulating brain metastatic tumors
Wong, S. T., Zhao, H., Rostomily, R. C. & Sheng, J.
2/15/20 → 1/31/25
Project: Federal Funding Agencies
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Modeling tumor-stroma crosstalk in lung cancer to identify targets for therapy
Wong, S. T., Li, F. & Zhao, H.
7/2/15 → 6/30/20
Project: Federal Funding Agencies
Research Output
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Emerging treatment strategies for breast cancer brain metastasis: from translational therapeutics to real-world experience
Ren, D., Cheng, H., Wang, X., Vishnoi, M., Teh, B. S., Rostomily, R., Chang, J. C., Wong, S. T. & Zhao, H., Jun 30 2020, In : Therapeutic Advances in Medical Oncology. 12Research output: Contribution to journal › Review article
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OCIAD1 contributes to neurodegeneration in Alzheimer’s disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages
Li, X., Wang, L., Cykowski, M. D., He, T., Liu, T., Chakranarayan, J., Rivera, A., Zhao, H., Powell, S. Z-E., Xia, W. & Wong, S. T., Jan 2020, In : EBioMedicine. 51, 102569.Research output: Contribution to journal › Article
Open Access3 Scopus citations -
Epithelial-Mesenchymal Plasticity in Organotropism Metastasis and Tumor Immune Escape
Nan, X., Wang, J., Liu, H. N., Wong, S. T. C. & Zhao, H., May 25 2019, In : journal of clinical medicine. 8, 5Research output: Contribution to journal › Review article
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Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways
Nan, X., Wang, J., Cheng, H., Yin, Z., Sheng, J., Qiu, B., Lau, C. C., Yustein, J. T., Zhao, H. & Wong, S. T. C., 2019, In : Cancer Letters.Research output: Contribution to journal › Article
1 Scopus citations -
Systems biology-based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma
Huang, L., Injac, S. G., Cui, K., Braun, F., Lin, Q., Du, Y., Zhang, H., Kogiso, M., Lindsay, H., Zhao, S., Baxter, P., Adekunle, A., Man, T. K., Zhao, H., Li, X. N., Lau, C. C. & Wong, S. T., Oct 24 2018, In : Science translational medicine. 10, 464, eaat0150.Research output: Contribution to journal › Article
16 Scopus citations
Prizes
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Houston Methodist Cancer Symposium Best Abstract Award
Zhao, Hong (Recipient), Aug 12 2016
Prize: Prize (including medals and awards)