Projects per year
Personal profile
Personal profile
Dr. Zhao joined the Houston Methodist Research Institute in 2008. She is a member of the American Association for Cancer Research and the International Association for Biological and Medical Research. She has been published in prestigious journals including Science Translational Medicine, Cancer Cell, Cancer Research, et al.
Research interests
Dr. Zhao's research uses systems biology approaches to study and combat brain metastatic cancer. Her projects integrate "dry lab" computational modeling with "wet lab" experimental testing to discover effective treatment strategies and explore personalized drug combinations.
Education/Academic qualification
Biological Sciences, Postdoctoral Fellowship, Harvard University
Molecular Imaging & Systems Biology, Postdoctoral Fellowship, Houston Methodist
Neurology, PhD, Shanghai Medical College of Fudan University
Research Area Keywords
- Cancer
Free-text keywords
- Breast cancer
- Brain metastasis
- Systems biology
- Computational modeling
- Imaging
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Collaborations and top research areas from the last five years
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Projects
- 4 Finished
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Systematic identification of astrocyte-tumor crosstalk regulating brain metastatic tumors
Zhao, H. (PI)
2/1/22 → 1/31/25
Project: Federal Funding Agencies
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Systematic identification of astrocyte-tumor crosstalk regulating brain metastatic tumors
Wong, S. T. (PI), Zhao, H. (PI) & Sheng, J. (Key Personnel)
8/1/20 → 1/31/25
Project: Federal Funding Agencies
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Systematic identification of astrocyte-tumor crosstalk regulating brain metastatic tumors
Wong, S. T. (PI), Zhao, H. (PI), Rostomily, R. C. (Key Personnel) & Sheng, J. (Key Personnel)
2/15/20 → 1/31/25
Project: Federal Funding Agencies
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Modeling tumor-stroma crosstalk in lung cancer to identify targets for therapy
Wong, S. T. (PI), Li, F. (Key Personnel) & Zhao, H. (Key Personnel)
7/2/15 → 6/30/20
Project: Federal Funding Agencies
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GD3 synthase drives resistance to p53-induced apoptosis in breast cancer by modulating mitochondrial function
Anand, V., El-Dana, F., Baran, N., Borgman, J., Yin, Z., Zhao, H., Wong, S. T., Andreeff, M. & Battula, V. L., 2025, (Accepted/In press) In: Oncogene. 509.Research output: Contribution to journal › Article › peer-review
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Hydroxytyrosol, a Component of Olive Oil for Breast Cancer Prevention in Women at High Risk of Cancer
Puri, A., Yin, Z., Granados-Principal, S., Ensor, J., Guzman, L., Rosato, R., Zhao, H., Wong, S., Wang, L., Patel, T. & Chang, J. C., 2025, In: International Journal of Breast Cancer. 2025, 1, 8831168.Research output: Contribution to journal › Article › peer-review
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Multiscale 3D spatial analysis of the tumor microenvironment using whole-tissue digital histopathology
Kermany, D. S., Ahn, J. Y., Vasquez, M., Zhang, W., Wang, L., Liu, K., Xu, Z., Cho, M. S., Carlos-Alcalde, W., Lee, H., Raghunathan, R., Sheng, J., Hao, X., Zhao, H., Afshar-Kharghan, V., Zhang, X. H. F. & Wong, S. T. C., Mar 2025, In: Cancer Communications. 45, 3, p. 386-390 5 p.Research output: Contribution to journal › Letter › peer-review
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Beyond Primary HER2 Expression: Trastuzumab Deruxtecan’s Efficacy in Brain Metastasis
Das, G., Wong, S. T. C. & Zhao, H., Oct 2024, In: Cancers. 16, 20, 3525.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Label-free optical imaging for brain cancer assessment
Raghunathan, R., Vasquez, M., Zhang, K., Zhao, H. & Wong, S. T. C., Jun 2024, In: Trends in Cancer. 10, 6, p. 557-570 14 p.Research output: Contribution to journal › Review article › peer-review
4 Scopus citations
Prizes
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Houston Methodist Cancer Symposium Best Abstract Award
Zhao, H. (Recipient), Aug 12 2016
Prize: Prize (including medals and awards)
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Houston Methodist Cornerstone Award
Zhao, H. (Recipient), Feb 2020
Prize: Prize (including medals and awards)