Personal profile

Dr. Pownall’s doctoral training was in physical chemistry with postdoctoral fellowships in molecular spectroscopy at the University of Houston, and biochemistry at Baylor College of Medicine with an emphasis on lipid metabolism. Over time he moved his studies from molecules to in vivo models, studying biophysics, peptide design, lipid synthesis and enzymology, and cell and molecular biology. His work is centered on high density lipoprotein therapeutics, and energy metabolism as it relates to obesity-linked diabetes and human lipid metabolism. A major goal of his research is to determine how alcohol ingestion contributes to enhanced postprandial lipemia, attendant pancreatitis, or alcohol-induced reduction of cardiovascular disease, an effect mediated by increased HDL-cholesterol.

His research is multidisciplinary, with extensive collaboration with structural biologists, endocrinologists, and x-ray crystallographers. Structural biologists provide expertise in lipid and lipoprotein structure by electron cryo microscopy. Endocrinologists have synergistic interests in the lipid disorders found in HIV-positive patients on highly active anti retroviral therapies. X-ray crystallographers help discern the total structure of Streptococcal serum opacity factor (SOF) for determination of structure function relationships.

Dr. Pownall maintains an active academic program. He is a member of three graduate programs at Baylor College of Medicine (Structural Computational Biology and Molecular Biophysics, Cell and Molecular Biology, and Cardiovascular Sciences) in which he teaches classes and serves on graduate advisory and qualifying exams committees. He is also active in community education, giving lectures on molecular ethics to local groups including several churches, home owner associations and garden clubs.

Research interests

Dr. Pownall’s studies encompass multiple aspects of lipid metabolism, particularly HDL structure, properties and function in the context of obesity-linked diabetes and atherogenesis. His research goals are as follows:

-To determine if Streptococcal serum opacity factor (SOF) can enhance cholesterol disposal and reverse atherosclerosis
-To obtain a high resolution X-ray structure of SOF for the identification of active sites and design of SOF analogs
-To compare the energy storage potential of central and femoral gluteal depots, as they relate to obesity-linked diabetes
-To assess the effects of acetate, as an alcohol metabolite and in the food supply, on HDL levels and the onset of pancreatitis

Keywords

    Research Area Keywords

  • Heart & Vascular

    Free-text keywords

  • Physical chemistry, Obesity-linked diabetes, Cholesterol transport, Atherogenesis, Fluorescence

Fingerprint

HDL Lipoproteins
Concept: HDL Lipoproteins
Weight: 100%
Domain: Medicine & Life Sciences
Lipids
Concept: Lipids
Weight: 77%
Domain: Medicine & Life Sciences
Apolipoprotein A-I
Concept: Apolipoprotein A-I
Weight: 65%
Domain: Medicine & Life Sciences
Apolipoproteins
Concept: Apolipoproteins
Weight: 56%
Domain: Medicine & Life Sciences
Lipoproteins
Concept: Lipoproteins
Weight: 55%
Domain: Medicine & Life Sciences
Plasma (human)
Concept: Plasma (human)
Weight: 55%
Domain: Chemical Compounds
Phospholipids
Concept: Phospholipids
Weight: 53%
Domain: Medicine & Life Sciences
Phosphatidylcholines
Concept: Phosphatidylcholines
Weight: 52%
Domain: Medicine & Life Sciences
Phosphatidylcholine-Sterol O-Acyltransferase
Concept: Phosphatidylcholine-Sterol O-Acyltransferase
Weight: 47%
Domain: Medicine & Life Sciences
Cholesterol
Concept: Cholesterol
Weight: 42%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Henry J. Pownall is tagged with the concept

Journals

Biochemistry

ISSNs: 0006-2960

American Chemical Society

Journal

52

The Journal of biological chemistry

ISSNs: 0021-9258

American Society for Biochemistry and Molecular Biology Inc.

Journal

32

Journal of Lipid Research

ISSNs: 0022-2275

American Society for Biochemistry and Molecular Biology Inc.

Journal

20

Biochimica et Biophysica Acta - Lipids and Lipid Metabolism

ISSNs: 0005-2760

Elsevier BV

Journal

13

Arteriosclerosis, thrombosis, and vascular biology

ISSNs: 1079-5642, 1524-4636

Lippincott Williams and Wilkins

Journal

10
has published Research OutputsResearch Output by Henry J. Pownall

Research Network

Visualization: Institutional Network

Click on a line in the diagram to see collaboration details.

Click icons to see information about the content.

Henry J. Pownall

Visualization: Co-author Network

Click on a line in the diagram to see collaboration details.

Click icons to see information about the content.

Henry J. Pownall

Shared Pub. Internal Organizations

Department of Medicine

Organizational unit: Departments

4

Department of Nanomedicine

Organizational unit: Departments

2

Department of Cardiovascular Surgery

Organizational unit: Departments

1
has Research OutputsResearch Output by Henry J. Pownall

Shared Pub. External Organizations

Baylor College of Medicine

External organization: Unknown

153

Houston Methodist Research Institute

External organization: Unknown

81

University of Tennessee Health Science Center

External organization: Unknown

27

Massachusetts General Hospital

External organization: Unknown

18

University of Pennsylvania

External organization: Unknown

18
has Research OutputsResearch Output by Henry J. Pownall

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Henry J. Pownall

Shared Pub. External co-authors

John B. Massey

External person

59

L. C. Smith

External person

24

Joel Morrisett

External person

24

James T. Sparrow

External person

22

Karen C. Johnson

External person

20
has co-authored Research OutputsResearch Output with Henry J. Pownall

ID: 2283532