Projects per year
Personal profile
Personal profile
Dr. Shen earned his M.D. degree in 1985 from Zhejiang University Medical School in Hangzhou, China and his Ph.D. degree in 1997 from the Graduate School of Biomedical Sciences at the University of Texas at Houston and MD Anderson Cancer Center in Houston, Texas. After completing a four-year postdoctoral fellowship at the National Cancer Institute, he entered the pharmaceutical industry as a drug development scientist. He returned to Academia in 2010. Dr. Shen is currently Professor of Nanomedicine, Houston Methodist Academic Institute, Full Member, Houston Methodist Research Institute, and Member of Houston Methodist Cancer Center. He is also on faculty at Weill Cornell Medical College in New York, New York.
Research interests
Dr. Shen's research interest is on the development of effective treatments for human cancers. His research team has designed and developed (1) an injectable nanoparticle generator platform for targeted delivery and in situ activation of prodrugs at the tumor lesions, (2) an inflammatory tumor vasculature-targeted delivery system for small molecule inhibitors and therapeutic siRNA, and (3) a highly potent therapeutic cancer nanovaccine platform. Researchers in the lab are applying these technology platforms to treat multiple cancer types. Multiple projects from Dr. Shen’s laboratory have been promoted from research to drug development and clinical applications.
Education/Academic qualification
Postdoctoral Fellowship, National Cancer Institute (NCI)
PhD, The University of Texas at Houston, Graduate School of Biomedical Sciences
External positions
Assistant Professor, Weill Cornell Medical College
Feb 2012 → …Research Area Keywords
- Nanomedicine
- Cancer
- Immunobiology & Inflammation
Free-text keywords
- Drug delivery
- Experimental cancer therapy
- Cancer vaccine
- Nanotechnology
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
Targeting the Inflammasome As a Treatment Strategy for COVID-19 infected cancer patients
Chang, J. C., Shen, H. & Rosato, R. R.
8/17/20 → 7/31/21
Project: Federal Funding Agencies
Novel Therapeutic Strategies to Co-Target AR+ and AR-/lo Prostate Cancer Cells
6/1/19 → 5/31/24
Project: Federal Funding Agencies
Mechanism of Intratumoral Transport of Particulate Drugs
Shen, H., Chen, S. & Ferrari, M.
6/15/18 → 11/30/23
Project: Federal Funding Agencies
Center for Immunotherapeutic Transport Oncophysics
Shen, H., Herzog, T., Kojic, M., Li, Z., Liu, X., Schrefler, B. A., Tasciotti, E., Wang, R. & Ziemys, A.
8/29/16 → 7/31/21
Project: Federal Funding Agencies
Research Output
An injectable nanoparticle generator enhances delivery of cancer therapeutics
Xu, R., Zhang, G., Mai, J., Deng, X., Segura-Ibarra, V., Wu, S., Shen, J., Liu, H., Hu, Z., Chen, L., Huang, Y., Koay, E., Huang, Y., Liu, J., Ensor, J. E., Blanco, E., Liu, X., Ferrari, M. & Shen, H., Apr 1 2016, In : Nature Biotechnology. 34, 4, p. 414-418 5 p.Research output: Contribution to journal › Article
157
Scopus
citations
Effective concentration of a multi-kinase inhibitor within bone marrow correlates with in vitro cell killing in therapy-resistant chronic myeloid leukemia
Mu, C., Wu, X., Ma, H., Tao, W., Zhang, G., Xia, X., Shen, J., Mai, J., Sun, T., Sun, X., Arlinghaus, R. B. & Shen, H., Feb 4 2016, In : Molecular Cancer Therapeutics.Research output: Contribution to journal › Article
3
Scopus
citations
Principles of nanoparticle design for overcoming biological barriers to drug delivery
Blanco, E., Shen, H. & Ferrari, M., Sep 8 2015, In : Nature Biotechnology. 33, 9, p. 941-951 11 p.Research output: Contribution to journal › Review article
1937
Scopus
citations
Porous Silicon Microparticle Potentiates Anti-Tumor Immunity by Enhancing Cross-Presentation and Inducing Type I Interferon Response
Xia, X., Mai, J., Xu, R., Perez, J. E. T., Guevara, M. L., Shen, Q., Mu, C., Tung, H. Y., Corry, D. B., Evans, S. E., Liu, X., Ferrari, M., Zhang, Z., Li, X. C., Wang, R. F. & Shen, H., May 12 2015, In : Cell Reports. 11, 6, p. 957-966 10 p.Research output: Contribution to journal › Article
45
Scopus
citations
Bone marrow endothelium-targeted therapeutics for metastatic breast cancer
Mai, J., Huang, Y., Mu, C., Zhang, G., Xu, R., Guo, X., Xia, X., Volk, D. E., Lokesh, G. L., Thiviyanathan, V., Gorenstein, D. G., Liu, X., Ferrari, M. & Shen, H., Aug 10 2014, In : Journal of Controlled Release. 187, p. 22-29 8 p.Research output: Contribution to journal › Article
40
Scopus
citations