• 9851 Citations
  • 35 h-Index

Research output per year

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Personal profile

Personal profile

Dr. Shen earned his M.D. degree in 1985 from Zhejiang University Medical School in Hangzhou, China and his Ph.D. degree in 1997 from the Graduate School of Biomedical Sciences at the University of Texas at Houston and MD Anderson Cancer Center in Houston, Texas. After completing a four-year postdoctoral fellowship at the National Cancer Institute, he entered the pharmaceutical industry as a drug development scientist. He returned to Academia in 2010. Dr. Shen is currently Professor of Nanomedicine, Houston Methodist Academic Institute, Full Member, Houston Methodist Research Institute, and Member of Houston Methodist Cancer Center. He is also on faculty at Weill Cornell Medical College in New York, New York.

Research interests

Dr. Shen's research interest is on the development of effective treatments for human cancers. His research team has designed and developed (1) an injectable nanoparticle generator platform for targeted delivery and in situ activation of prodrugs at the tumor lesions, (2) an inflammatory tumor vasculature-targeted delivery system for small molecule inhibitors and therapeutic siRNA, and (3) a highly potent therapeutic cancer nanovaccine platform. Researchers in the lab are applying these technology platforms to treat multiple cancer types. Multiple projects from Dr. Shen’s laboratory have been promoted from research to drug development and clinical applications.

Education/Academic qualification

Postdoctoral Fellowship, National Cancer Institute (NCI)

PhD, The University of Texas at Houston, Graduate School of Biomedical Sciences

External positions

Assistant Professor, Weill Cornell Medical College

Feb 2012 → …

Research Area Keywords

  • Nanomedicine
  • Cancer
  • Immunobiology & Inflammation

Free-text keywords

  • Drug delivery
  • Experimental cancer therapy
  • Cancer vaccine
  • Nanotechnology

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Mechanism of Intratumoral Transport of Particulate Drugs

Shen, H., Chen, S. & Ferrari, M.


Project: Federal Funding Agencies

Development of therapeutic mRNA vaccine

Shen, H.


Project: Non Profit

Research Output

An injectable nanoparticle generator enhances delivery of cancer therapeutics

Xu, R., Zhang, G., Mai, J., Deng, X., Segura-Ibarra, V., Wu, S., Shen, J., Liu, H., Hu, Z., Chen, L., Huang, Y., Koay, E., Huang, Y., Liu, J., Ensor, J. E., Blanco, E., Liu, X., Ferrari, M. & Shen, H., Apr 1 2016, In : Nature Biotechnology. 34, 4, p. 414-418 5 p.

Research output: Contribution to journalArticle

  • 157 Scopus citations

    Effective concentration of a multi-kinase inhibitor within bone marrow correlates with in vitro cell killing in therapy-resistant chronic myeloid leukemia

    Mu, C., Wu, X., Ma, H., Tao, W., Zhang, G., Xia, X., Shen, J., Mai, J., Sun, T., Sun, X., Arlinghaus, R. B. & Shen, H., Feb 4 2016, In : Molecular Cancer Therapeutics.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Principles of nanoparticle design for overcoming biological barriers to drug delivery

    Blanco, E., Shen, H. & Ferrari, M., Sep 8 2015, In : Nature Biotechnology. 33, 9, p. 941-951 11 p.

    Research output: Contribution to journalReview article

  • 1937 Scopus citations

    Porous Silicon Microparticle Potentiates Anti-Tumor Immunity by Enhancing Cross-Presentation and Inducing Type I Interferon Response

    Xia, X., Mai, J., Xu, R., Perez, J. E. T., Guevara, M. L., Shen, Q., Mu, C., Tung, H. Y., Corry, D. B., Evans, S. E., Liu, X., Ferrari, M., Zhang, Z., Li, X. C., Wang, R. F. & Shen, H., May 12 2015, In : Cell Reports. 11, 6, p. 957-966 10 p.

    Research output: Contribution to journalArticle

  • 45 Scopus citations

    Bone marrow endothelium-targeted therapeutics for metastatic breast cancer

    Mai, J., Huang, Y., Mu, C., Zhang, G., Xu, R., Guo, X., Xia, X., Volk, D. E., Lokesh, G. L., Thiviyanathan, V., Gorenstein, D. G., Liu, X., Ferrari, M. & Shen, H., Aug 10 2014, In : Journal of Controlled Release. 187, p. 22-29 8 p.

    Research output: Contribution to journalArticle

  • 40 Scopus citations