Personal profile

Dr. Gavin Britz earned his MBBCh at the University of the Witwatersrand School of Medicine, South Africa in 1987.  He completed a surgical internship in general surgery and fellowship in general surgery at Johns Hopkins Hospital, Baltimore in 1993 and in 2002 he completed his residency in neurosurgery.  During his residency he attended St. George’s Medical School, The University of London, UK and served as a Neurosurgical Registrar and Senior Registrar.  After residency, he took a cerebrovascular fellowship in 2002 and an Interventional Neuroradiology Fellowship in 2003 at the University of Washington Medical School, Seattle.  In 2003 he earned his MPH at the University of Washington, Seattle. He also obtained an MBA from George Washington University in 2015. He held faculty appointments at the University of Washington and Duke University before becoming a member of Houston Methodist Research Institute in 2014.

Research interests

My basic science research focuses on understanding the cerebral microcirculation. This is largely in relation to the alteration of the microcirculation following an aneurysmal subarachnoid hemorrhage. Subarachnoid hemorrhage resulting from rupture of a brain aneurysm often demonstrates significant morbidity and mortality in spite of aneurysm obliteration to prevent re-hemorrhage. In humans, delayed vascular constriction can occur 5-7 days after SAH: proximal blood vessels lose reactivity and demonstrate narrowing unresponsive to smooth muscle relaxants, often leading to delayed cerebral ischemia. However, ischemic deficits can also arise from regions with minimal vasoconstriction on angiography or transcranial Doppler studies, and drugs preventing large vessel vasoconstriction may fail to improve clinical outcome. Microvascular dysfunction and acute brain injury from SAH are also important in the evolution of ischemia. Animal models of SAH can replicate features of human SAH, particularly partial vessel rupture and release of arterial blood, ischemic and cognitive changes but demonstrate a shorter time course of vasoconstriction (maximum at 2-3 days). Hippocampus has a less robust blood supply than neocortex, with resulting lower oxygen values in vivo, in addition to a predisposition to ischemia and cell loss. My laboratory has clearly demonstrated that both the pial and penetrating arterioles are affected and therefore may account for some of the morbidity despite successful treatment of the aneurysm.

My clinical research includes evaluating new and novel tools to treat a wide variety of problems such as brain aneurysms and skull base tumors.

Keywords

    Research Area Keywords

  • Neurosciences

    Free-text keywords

  • Brain Tumors, Aneurysms, Acoustic Neuroma, AVM arteriovenous malformation, Moyamoya, Meningioma, Carotid Endarterectomy, Neuro-Vascular Surgery, Pituitary Surgery, Skull Based Surgery, Trigeminal Neuralgia

External positions

Professor of Neurological Surgery, Weill Cornell Medical College

Fingerprint

Intracranial Aneurysm
Concept: Intracranial Aneurysm
Weight: 100%
Domain: Medicine & Life Sciences
Subarachnoid Hemorrhage
Concept: Subarachnoid Hemorrhage
Weight: 74%
Domain: Medicine & Life Sciences
Aneurysm
Concept: Aneurysm
Weight: 67%
Domain: Medicine & Life Sciences
Stents
Concept: Stents
Weight: 29%
Domain: Medicine & Life Sciences
Stroke
Concept: Stroke
Weight: 28%
Domain: Medicine & Life Sciences
Equipment and Supplies
Concept: Equipment and Supplies
Weight: 22%
Domain: Medicine & Life Sciences
Cerebrovascular Circulation
Concept: Cerebrovascular Circulation
Weight: 22%
Domain: Medicine & Life Sciences
Therapeutics
Concept: Therapeutics
Weight: 20%
Domain: Medicine & Life Sciences
Basilar Artery
Concept: Basilar Artery
Weight: 19%
Domain: Medicine & Life Sciences
Blood Vessels
Concept: Blood Vessels
Weight: 19%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Gavin W. Britz is tagged with the concept

Journals

Neurosurgery.

ISSNs: 0148-396X

Additional searchable ISSN (Electronic): 1524-4040

Lippincott Williams and Wilkins

Journal

40

Journal of Neurosurgery

ISSNs: 0022-3085

American Association of Neurological Surgeons

Journal

14

World Neurosurgery

ISSNs: 1878-8750

Elsevier

Journal

13

Stroke

ISSNs: 0039-2499

Additional searchable ISSN (Electronic): 1524-4628

Journal

10

Journal of NeuroInterventional Surgery

ISSNs: 1759-8478

Additional searchable ISSN (Electronic): 1759-8486

BMJ Publishing Group

Journal

9
has published Research OutputsResearch Output by Gavin W. Britz

Research Network

Visualization: Institutional Network

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Gavin W. Britz

Visualization: Co-author Network

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Gavin W. Britz

Shared Pub. Internal Organizations

Department of Radiology

Organizational unit: Departments

16

Department of Pathology & Genomic Medicine

Organizational unit: Departments

4
3

Department of Urology

Organizational unit: Departments

1

Cancer Center

Organizational unit: Centers of Excellence

1
has Research OutputsResearch Output by Gavin W. Britz

Shared Pub. External Organizations

Duke University Medical Center

External organization: Unknown

26

Harborview Medical Center

External organization: Unknown

26

University of Washington Cardiovascular Health Research Unit

External organization: Unknown

24

Duke University

External organization: Unknown

16

Houston Methodist Research Institute

External organization: Unknown

11
has Research OutputsResearch Output by Gavin W. Britz

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Gavin W. Britz

Shared Pub. External co-authors

D. W. Newell

External person

20

Ali R. Zomorodi

External person

18

B. Ghodke

External person

15

Alex Abou-Chebl

External person

14

H. Richard Winn

External person

13
has co-authored Research OutputsResearch Output with Gavin W. Britz

ID: 2286013