Gavin W. Britz, MBBCh, MPH, MBA, FAANS

  • Phone713-441-3800
  • 4034 Citations
  • 35 h-Index
19952020

Research output per year

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Personal profile

Personal profile

Dr. Gavin Britz is the Chairman of Department of Neurosurgery, the Candy and Tom Knudson Centennial Chair in Neurosurgery, Director of the Houston Methodist Neurological Institute and Professor of Neurosurgery at Weill Cornell Medical College. Dr. Britz earned his MBBCh at the University of the Witwatersrand School of Medicine, South Africa in 1987.  He completed a surgical internship in general surgery and fellowship in general surgery at Johns Hopkins Hospital, Baltimore in 1993 and in 2002 he completed his residency in neurosurgery at the University of Washington in Seattle.  During his residency he attended St. George’s Medical School, The University of London, UK and served as a Neurosurgical Registrar and Senior Registrar.  After residency, he took a cerebrovascular fellowship in 2002 and an Interventional Neuroradiology Fellowship in 2003 at the University of Washington Medical School, Seattle.  In 2003 he earned his MPH at the University of Washington, Seattle. He also obtained an MBA from George Washington University in 2015. He held faculty appointments at the University of Washington and Duke University before becoming a member of Houston Methodist Research Institute in 2014.

Research interests

My basic science research focuses on understanding the cerebral microcirculation. This is largely in relation to the alteration of the microcirculation following an aneurysmal subarachnoid hemorrhage. Subarachnoid hemorrhage resulting from rupture of a brain aneurysm often demonstrates significant morbidity and mortality in spite of aneurysm obliteration to prevent re-hemorrhage. In humans, delayed vascular constriction can occur 5-7 days after SAH: proximal blood vessels lose reactivity and demonstrate narrowing unresponsive to smooth muscle relaxants, often leading to delayed cerebral ischemia. However, ischemic deficits can also arise from regions with minimal vasoconstriction on angiography or transcranial Doppler studies, and drugs preventing large vessel vasoconstriction may fail to improve clinical outcome. Microvascular dysfunction and acute brain injury from SAH are also important in the evolution of ischemia. Animal models of SAH can replicate features of human SAH, particularly partial vessel rupture and release of arterial blood, ischemic and cognitive changes but demonstrate a shorter time course of vasoconstriction (maximum at 2-3 days). Hippocampus has a less robust blood supply than neocortex, with resulting lower oxygen values in vivo, in addition to a predisposition to ischemia and cell loss. My laboratory has clearly demonstrated that both the pial and penetrating arterioles are affected and therefore may account for some of the morbidity despite successful treatment of the aneurysm.

My clinical research includes evaluating new and novel tools to treat a wide variety of problems such as brain aneurysms and skull base tumors.

Education/Academic qualification

MBA, George Washington University

… → 2015

Public Health, MPH, University of Washington

… → 2003

Interventional Neuroradiology, Clinical Fellowship, University of Washington

… → 2003

Cerebrovascular Disease, Clinical Fellowship, University of Washington

… → 2002

Neurosurgery, Residency, University of Washington

… → 2002

General Surgery, Clinical Fellowship, Johns Hopkins University and Hospital

… → 1993

Neurosurgery, Internship, University of the Witwatersrand

… → 1988

MBBCh, University of the Witwatersrand

… → 1987

External positions

Professor of Neurological Surgery, Weill Cornell Medical College

Research Area Keywords

  • Neurosciences

Free-text keywords

  • Brain Tumors
  • Aneurysms
  • Acoustic Neuroma
  • AVM arteriovenous malformation
  • Moyamoya
  • Meningioma
  • Carotid Endarterectomy
  • Neuro-Vascular Surgery
  • Pituitary Surgery
  • Skull Based Surgery
  • Trigeminal Neuralgia

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Projects

Research Output

Feasibility of Robotic-Assisted Neurovascular Interventions: Initial Experience in Flow Model and Porcine Model

Britz, G. W., Tomas, J. & Lumsden, A., Feb 1 2020, In : Clinical Neurosurgery. 86, 2, p. 309-314 6 p.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    Initial Experience in a Pig Model of Robotic-Assisted Intracranial Arteriovenous Malformation (AVM) Embolization

    Desai, V. R., Lee, J. J., Tomas, J., Lumsden, A. B. & Britz, G. W., Aug 1 2020, In : Operative neurosurgery (Hagerstown, Md.). 19, 2, p. 205-209 5 p.

    Research output: Contribution to journalArticle

  • Intraspinal mesenchymal chondrosarcoma: An argument for aggressive local resection and adjuvant therapy based on review of the literature

    Gopakumar, S., Steele, W. J., Muir, M., Bhogani, Z. & Britz, G. W., May 2 2020, In : Surgical Neurology International. 11, 95, 95.

    Research output: Contribution to journalArticle

  • Operative Treatment of a Superior Cerebellar Artery Perforator Dissecting Aneurysm

    Lee, J. J., Huang, M., Guerrero, J., Desai, V. R., Jenson, A., Austerman, R., Diaz, O. M. & Britz, G. W., Aug 1 2020, In : Operative neurosurgery (Hagerstown, Md.). 19, 2, p. E203-E208

    Research output: Contribution to journalArticle

  • Pivotal Trial of the Neuroform Atlas Stent for Treatment of Anterior Circulation Aneurysms: One-Year Outcomes

    ATLAS Investigators, Jun 17 2020, In : Stroke. 51, 7, p. 2087-2094 8 p.

    Research output: Contribution to journalArticle