Projects per year
Personal profile
Research interests
Dr. Leonard’s research focuses on nanomedicine design for polymeric and lipid nanoparticle platforms. She is particularly interested in macrophage modulation via in vivo targeted CRISPR editing in various inflammatory conditions such as atherosclerosis, inflammatory bowel disease, and cancer. She has also developed several disease‐specific 3D in vitro models for drug screening and assessing treatment efficacy metrics
Education/Academic qualification
ME, Technical University of Berlin
PhD, Universität des Saarlandes
Research Area Keywords
- Nanomedicine
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Collaborations and top research areas from the last five years
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Projects
- 2 Finished
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Evaluation of immune responses to CD44-targeted nanovectors for designing a novel anti-tuberculosis host-directed therapy
Godin, B., Jagannath, C. & Leonard, F.
5/1/20 → 10/31/22
Project: Federal Funding Agencies
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CRISPR-nanoparticle for macrophage reprogramming: New therapeutic strategy for breast cancer liver metastasis
4/1/19 → 3/10/21
Project: Non Profit
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Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks
Chakraborty, S., Singh, M., Pandita, R. K., Singh, V., Lo, C. S. C., Leonard, F., Horikoshi, N., Moros, E. G., Guha, D., Hunt, C. R., Chau, E., Ahmed, K. M., Sethi, P., Charaka, V., Godin, B., Makhijani, K., Scherthan, H., Deck, J., Hausmann, M., Mushtaq, A., & 6 others, Apr 15 2022, In: iScience. 25, 4, 104142.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Design and in vitro characterization of multistage silicon-PLGA budesonide particles for inflammatory bowel disease
Leonard, F., Srinivasan, S., Liu, X., Collnot, E. M., Ferrari, M., Lehr, C. M. & Godin, B., Jun 1 2020, In: European Journal of Pharmaceutics and Biopharmaceutics. 151, p. 61-72 12 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Immuntherapeutika gegen Kopf-Hals-Plattenepithelkarzinom-Stammzellen
Translated title of the contribution :Immunotherapeutics for head and neck squamous cell carcinoma stem cells Research output: Contribution to journal › Review article › peer-review
4 Scopus citations -
Insights into nanomedicine for immunotherapeutics in squamous cell carcinoma of the head and neck
Xu, Q., Fang, M., Zhu, J., Dong, H., Cao, J., Yan, L., Leonard, F., Oppel, F., Sudhoff, H., Kaufmann, A. M., Albers, A. E. & Qian, X., Jul 19 2020, In: International Journal of Biological Sciences. 16, 14, p. 2506-2517 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access9 Scopus citations -
Nonlinear response to cancer nanotherapy due to macrophage interactions revealed by mathematical modeling and evaluated in a murine model via CRISPR-modulated macrophage polarization
Leonard, F., Curtis, L. T., Hamed, A. R., Zhang, C., Chau, E., Sieving, D., Godin, B. & Frieboes, H. B., May 1 2020, In: Cancer Immunology, Immunotherapy. 69, 5, p. 731-744 14 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations