Projects per year
Personal profile
Personal profile
Dr. Altamirano received his Ph.D. degree in Biomedical Sciences from the University of Chile. He has extensive experience studying the molecular mechanisms that drive striated muscle pathology. His research focuses on understanding how mutations in the gene PKD1 affect cardiac function. PKD1 encodes for Polycystin-1 and is mutated in autosomal dominant polycystic kidney disease (ADPKD) Recently, Dr. Altamirano received a Career Development Award from the American Heart Association to continue his independent research. In 2020, as a new assistant professor, he started his own lab at Houston Methodist Research Institute in Houston, aiming to uncover the role of Polycystin-1 in cardiovascular function and electrical remodeling.
External positions
Assistant Professor of Molecular Biology in Cardiothoracic Surgery, Weill Cornell Medicine
Jun 1 2020 → …
Research Area Keywords
- Heart & Vascular
- Regenerative Medicine
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Collaborations and top research areas from the last five years
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Mechanisms driving cardiac dysfunction in Autosomal Dominant Polycystic Kidney Disease
Altamirano, F. (PI)
5/15/22 → 4/30/27
Project: Federal Funding Agencies
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Regulation of Glycogen Synthase 3 pathway by Polycystin-1 in Cardiomyocytes
Altamirano, F. (PI)
2/1/20 → 1/31/21
Project: Federal Funding Agencies
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Polycystin-1-dependent governance of cardiomyocyte hypertrophy via potassium channel control
Altamirano, F. (PI)
4/1/19 → 3/31/23
Project: Non Profit
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Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder
Xu, W., Cao, Y., Stephens, S. B., Arredondo, M. J., Chen, Y., Perez, W., Sun, L., Yu, A. C., Kim, J. J., Lalani, S. R., Li, N., Horrigan, F. T., Altamirano, F., Wehrens, X. H., Miyake, C. Y. & Zhang, L., Jun 10 2024, In: JCI insight. 9, 11, e171005.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization
Deogharia, M., Venegas-Zamora, L., Agrawal, A., Shi, M., Jain, A. K., McHugh, K. J., Altamirano, F., Marian, A. J. & Gurha, P., Apr 1 2024, In: Cardiovascular Research. 120, 6, p. 630-643 14 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts
Li, C., Li, S., Zhang, G., Li, Q., Song, W., Wang, X., Cook, J. A., van der Stoel, M., Wright, B. W., Altamirano, F., Niewold, E. L., Han, J., Kimble, G., Zhang, P., Luo, X., Urra, H., May, H. I., Ferdous, A., Sun, X. N. & Deng, Y. & 9 others, , Sep 24 2024, In: Circulation. 150, 13, p. 1010-1029 20 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Bridging the Translational Gap in Heart Failure Research: Using Human iPSC-derived Cardiomyocytes to Accelerate Therapeutic Insights
Venegas-Zamora, L., Fiedler, M., Perez, W. & Altamirano, F., 2023, In: Methodist DeBakey cardiovascular journal. 19, 5, p. 5-15 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury
Xie, M., Cho, G. W., Kong, Y., Li, D. L., Altamirano, F., Luo, X., Morales, C. R., Jiang, N., Schiattarella, G. G., May, H. I., Medina, J., Shelton, J. M., Ferdous, A., Gillette, T. G. & Hill, J. A., Jul 23 2021, In: Circulation Research. 129, 3, p. 435-450 16 p.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations
Prizes
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Pew Biomedical Scholars internal nomination Houston Methodist
Altamirano, F. (Recipient), 2022
Prize: Other distinction
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Troy Hendrickson obtained his predoctoral fellowship from American Heart Association
Altamirano, F. (Recipient), 2021
Prize: Fellowship awarded competitively
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WCGS Faculty Appointment for PBSB PhD program
Altamirano, F. (Recipient), Oct 3 2022
Prize: Appointment