Personal profile

Dr. Reineke’s independent research career is focused on metabolic and molecular signaling in the heart, with a specific focus on stress-induced changes. She completed her graduate studies in the lab of Dr. Hung-Ying Kao in the Department of Biochemistry at Case Western Reserve University in Cleveland, Ohio focused on the molecular aspects of cancer biology, and postdoctoral training with renowned endocrinologist Dr. Bert O’Malley in the Department of Molecular and Cellular Biology at Baylor College of Medicine in Houston, Texas. Postdoctoral studies included investigating transcriptional regulation of skeletal muscle metabolism by a class of transcription coactivators the steroid receptor coactivators (SRCs). These studies led into an unexpected path studying metabolic control in cardiac muscle especially during cardiac stress events. 

Research interests

Dr. Reineke’s research involves the critical interplay between metabolism and cardiac function during times of stress and she has gained a deep interest in uncovering the molecular regulation of this connection. Her research uncovered that loss of one SRC family member, SRC-2, results in substantial gene expression remodeling in the heart that causes significant alterations in the ability of the heart to compensate for increased stress. Characterization of this model has led to her current research and future research plans. While cardiovascular disease remains a leading cause of death in the United States, the molecular understanding of what molecular components mediate coordination of the major pathways involved in the cardiac stress response are largely unknown. Gaining an understanding of what drives the molecular changes during cardiac stress and how the different stress responsive pathways communicate with each other will lead to novel, invaluable information for the eventual treatment and perhaps prevention of cardiovascular disease. Her studies will focus on how metabolic changes, one of the earliest changes observed during cardiac stress, are sensed and translated to other molecular pathways and what regulates the timing and communication.

Keywords

    Research Area Keywords

  • Heart & Vascular

    Free-text keywords

  • Metabolism, Cardiovascular stress, Transcription regulation, Molecular signaling, Gene expression

Fingerprint

Nuclear Receptor Coactivator 2
Concept: Nuclear Receptor Coactivator 2
Weight: 100%
Domain: Medicine & Life Sciences
Gene expression
Concept: Gene expression
Weight: 31%
Domain: Chemical Compounds
Retinoic Acid Receptors
Concept: Retinoic Acid Receptors
Weight: 30%
Domain: Chemical Compounds
Histone Deacetylases
Concept: Histone Deacetylases
Weight: 29%
Domain: Medicine & Life Sciences
Nuclear Receptor Coactivator 3
Concept: Nuclear Receptor Coactivator 3
Weight: 27%
Domain: Medicine & Life Sciences
Gene Expression
Concept: Gene Expression
Weight: 24%
Domain: Medicine & Life Sciences
Glycine
Concept: Glycine
Weight: 22%
Domain: Medicine & Life Sciences
Cysteine
Concept: Cysteine
Weight: 21%
Domain: Medicine & Life Sciences
Metabolism
Concept: Metabolism
Weight: 20%
Domain: Chemical Compounds
Transcription
Concept: Transcription
Weight: 20%
Domain: Chemical Compounds
Research OutputsResearch Output authored by Erin L. Reineke is tagged with the concept

Journals

The Journal of biological chemistry

ISSNs: 0021-9258

American Society for Biochemistry and Molecular Biology Inc.

Journal

7

Molecular and Cellular Biology

ISSNs: 0270-7306

American Society for Microbiology

Journal

3

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

ISSNs: 1079-5006

Oxford University Press

Journal

2

FASEB Journal

ISSNs: 1530-6860, 0892-6638

FASEB

Journal

1

International Journal of Biological Sciences

ISSNs: 1449-2288

Ivyspring International Publisher

Journal

1
has published Research OutputsResearch Output by Erin L. Reineke

Research Network

Visualization: Institutional Network

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Erin L. Reineke

Visualization: Co-author Network

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Erin L. Reineke

Shared Pub. Internal Organizations

Department of Medicine

Organizational unit: Departments

7

Houston Methodist Hospital

Organizational unit: Schools & Hospitals

6

Center for Cardiovascular Regeneration

Organizational unit: Programs

1

Department of Cardiovascular Sciences

Organizational unit: Departments

1
has Research OutputsResearch Output by Erin L. Reineke

Shared Pub. External Organizations

Western Reserve University

External organization: Unknown

9

Baylor College of Medicine

External organization: Unknown

8

University Hospitals of Cleveland

External organization: Unknown

5

Houston Methodist Research Institute

External organization: Unknown

3

Houston Methodist Hospital

External organization: Medical

2
has Research OutputsResearch Output by Erin L. Reineke

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Erin L. Reineke

Shared Pub. External co-authors

Hung Ying Kao

External person

9

Mark L. Entman

External person

7

Bert W. O'Malley

External person

6

Yu Liu

External person

6

Brian York

External person

5
has co-authored Research OutputsResearch Output with Erin L. Reineke

ID: 16694096