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Dr. Enrica De Rosa is the Director of the Intravital Microscopy Core and the Laboratory Manager of the Nanomedicine Department, at the Houston Methodist Research Institute.
At the Universita' degli Studi di Napoli Federico II she earned her BS and MS in Chemical Engineering in 2001, and in 2004 her PhD in Chemical, Material and Production Engineering, specializing in Biomaterial and Transport Phenomena. During her awarded fully funded PhD scholarship she set up and validated an advanced microscopy technique (FRAP-Fluorescence Recovery After Photobleaching) to locally measure molecular diffusion for drug delivery and tissue engineering application. In 2007 she moved to Houston as senior postdoc in the Nanomedicine department of University of Texas, where she pioneered the development of an implantable subcutaneous nanodevice for long term constant drug delivery and of a weight bearing bio-nano-material able to regenerate the bone tissue in a critical size bone fracture. Her research led to the publication of many papers in well-known peer-reviewed journals. In April 2009 she was awarded the Heinlein Trust Microgravity Award to reward innovation in the use of microgravity to advance biotech, nanotech, combustion, metallurgy, and other fields. Since 2011 she has supported the Nanomedicine department research as Laboratory Manager at the Houston Methodist Research Institute and managed the Intravital Microscopy Core.
With her proficiency in live microscopy she was able to image and quantify drug delivery, targeting accumulation and vessel formation, in several organ and tissues, such as skin, liver, pancreas, brain, muscle, ear, intestine, lymphonodes. One of her recent works published on Nature Materials demonstrated that prototype porous silicon nanoneedles are a new more effective gene delivery method, able to induce 6 fold increase of blood vessel formation in vivo; paving the way for using this platform to successfully promote tissue regeneration and integration of new organs and implants.
In 2016 launched the Intravital Microscopy apparatus as core of the HMRI and under her leadership, research and financial experience the core can offer exceptional IVM services, with cutting edge IVM technology and image analysis tools at competitive prices.
Research Area Keywords
- Orthopedics & Sports Medicine
- Nanomedicine
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Projects
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Mechanisms of melanoma brain metastasis by CTCs isolated from patients' blood and CSF
12/15/17 → 7/31/19
Project: Federal Funding Agencies
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Biomimetic Nanoparticles as a Theranostic Tool for Traumatic Brain Injury
Zinger, A., Soriano, S., Baudo, G., De Rosa, E., Taraballi, F. & Villapol, S., Jul 23 2021, In: Advanced Functional Materials. 31, 30, p. 2100722 2100722.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Enhancing Inflammation Targeting Using Tunable Leukocyte-Based Biomimetic Nanoparticles
Zinger, A., Sushnitha, M., Naoi, T., Baudo, G., De Rosa, E., Chang, J., Tasciotti, E. & Taraballi, F., Apr 27 2021, In: ACS Nano. 15, 4, p. 6326-6339 14 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
LDL-Based Lipid Nanoparticle Derived for Blood Plasma Accumulates Preferentially in Atherosclerotic Plaque
Boada, C. A., Zinger, A., Rohen, S., Martinez, J. O., Evangelopoulos, M., Molinaro, R., Lu, M., Villarreal-Leal, R. A., Giordano, F., Sushnitha, M., De Rosa, E., Simonsen, J. B., Shevkoplyas, S., Taraballi, F. & Tasciotti, E., Dec 1 2021, In: Frontiers in Bioengineering and Biotechnology. 9, 794676.Research output: Contribution to journal › Article › peer-review
Open Access -
Tutorial: using nanoneedles for intracellular delivery
Chiappini, C., Chen, Y., Aslanoglou, S., Mariano, A., Mollo, V., Mu, H., De Rosa, E., He, G., Tasciotti, E., Xie, X., Santoro, F., Zhao, W., Voelcker, N. H. & Elnathan, R., Oct 2021, In: Nature Protocols. 16, 10, p. 4539-4563 25 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Leukocyte-mimicking nanovesicles for effective doxorubicin delivery to treat breast cancer and melanoma
Molinaro, R., Martinez, J. O., Zinger, A., De Vita, A., Storci, G., Arrighetti, N., De Rosa, E., Hartman, K. A., Basu, N., Taghipour, N., Corbo, C. & Tasciotti, E., Jan 2020, In: Biomaterials Science. 8, 1, p. 333-341 9 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations