Personal profile

Dr. Tasciotti earned his B.S. in Biological Sciences and his M.S. in Molecular Biology at Scuola Normale Superiore Pisa, Italy and a Ph.D. in Molecular Medicine from a joint program of the Scuola Normale Superiore Pisa with the International Center for Biotechnology and Genetic Engineering (ICGEB) in 2004. Dr. Tasciotti research as a PhD student focused on gene and stem cell therapy of cancer. He moved to the United States in 2006 as a senior postdoctoral fellow in the Department of Nanomedicine and Biomedical Engineering at the University of Texas Health Science Center at Houston. There, Dr. Tasciotti expanded his research to material science and nanotechnology and to their applications in the fields of early diagnostics, drug delivery and regenerative medicine. As a postdoctoral fellow he carried his research in molecular imaging of angiogenesis and cancer development at the Center of Molecular Medicine and in cancer nanomedicine at the Department of Biomedical Engineering at the University of Texas Health Science Center. There, he laid the groundwork of two nanotechnology platforms: protein nanochips for the early detection of diseases, and nanoporous silicon particles for the targeted delivery of therapeutics. The latter was featured on the cover of Nature Nanotechnology and paved the way for a field of investigation called the Multistage Delivery Approach, which was selected as one of the “Five big ideas for nanotechnology” by Nature Medicine in 2008.

In 2008, Dr. Tasciotti was appointed Assistant Professor in the Department of Nanomedicine at the University of Texas Medical School. There, he conceived and coordinated the research project: “BioNanoScaffold for post-traumatic osteo-regeneration”, and developed multifunctional biomaterials that provide immediate mechanical stabilization to bone fractures and promote bone tissue regeneration. This project was funded within the Fracture Putty program of the Defense Advanced Research Project Agency and has involved over 60 investigators from multiple institutions over the course of the last 5 years. Thanks to this project, Dr. Tasciotti established strong ties within the community of tissue engineering and regenerative medicine, particularly in the clinical fields of orthopedic, spine, maxillofacial, oral and dental surgery, and is now formalizing the clinical translation of this technology.

In 2010, he joined the Department of Nanomedicine at Houston Methodist Research Institute, where he serves as Co-Chair of the Department of Nanomedicine, Director of the Center for Regenerative Medicine, and Scientific Director of the Surgical Advanced Technology Lab. There, Dr. Tasciotti directs a large research operation, with 25 research staff and trainees involved in the development of innovative nanotechnology platforms and biomaterials for drug delivery and regenerative medicine. Dr. Tasciotti is an inventor on six U.S. patents, serves as reviewer for more than 20 scientific journals and is a frequent speaker at international meetings. He served from 2010 to 2012 as the president of the council of reviewers for the Italian Ministry of Health and is a regular member of National Institute of Health, US Department of Defense and NCI Innovative Molecular Analysis Technologies (IMAT) study sections. 

Research interests

-Biomimetic materials to improve tissue regeneration and modulate the immune response.
-Artificial biomimetic extracellular matrices for musculoskeletal drug delivery and regenerative medicine.
-Bio-inspired and cell-based delivery platforms for the active targeting of inflammation.
-Nanostructured hydrogels for the localized sustained release of clinically approved drugs.
-Development of new surgical procedures and clinical approaches using nano-based therapeutics.

Keywords

    Free-text keywords

  • Cancer, Nanotechnology, Regenerative medicine, Bioengineering, Drug delivery

    Research Area Keywords

  • Regenerative Medicine
  • Nanomedicine
  • Cancer
  • Molecular Medicine

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Biomimetics
Concept: Biomimetics
Weight: 100%
Domain: Medicine & Life Sciences
Silicon
Concept: Silicon
Weight: 79%
Domain: Chemical Compounds
Nanoparticles
Concept: Nanoparticles
Weight: 78%
Domain: Medicine & Life Sciences
Scaffolds
Concept: Scaffolds
Weight: 57%
Domain: Chemical Compounds
Nanotechnology
Concept: Nanotechnology
Weight: 49%
Domain: Medicine & Life Sciences
Stem cells
Concept: Stem cells
Weight: 47%
Domain: Chemical Compounds
Tissue
Concept: Tissue
Weight: 43%
Domain: Engineering & Materials Science
Silicon Dioxide
Concept: Silicon Dioxide
Weight: 41%
Domain: Chemical Compounds
Ventral Hernia
Concept: Ventral Hernia
Weight: 38%
Domain: Medicine & Life Sciences
Mesenchymal Stromal Cells
Concept: Mesenchymal Stromal Cells
Weight: 37%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Ennio Tasciotti is tagged with the concept

Journals

Small

ISSNs: 1613-6810

Additional searchable ISSN (Electronic): 1613-6829

Wiley

Journal

7

Journal of Tissue Engineering

ISSNs: 2041-7314

Additional searchable ISSN (Electronic): 2041-7314

SAGE-Hindawi Access to Research

Scopus rating (2018): SJR 0.823 SNIP 0.694

Journal

7

Nanomedicine

ISSNs: 1743-5889

Future Medicine Ltd.

Journal

6

Biomaterials

ISSNs: 0142-9612

Additional searchable ISSN (Electronic): 1878-5905

Elsevier BV

Journal

6

ACS Applied Materials and Interfaces

ISSNs: 1944-8244

Additional searchable ISSN (Electronic): 1944-8252

American Chemical Society

Journal

5
has published Research OutputsResearch Output by Ennio Tasciotti

Research Network

Visualization: Institutional Network

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Ennio Tasciotti

Visualization: Co-author Network

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Ennio Tasciotti

Shared Pub. Internal Organizations

Weill Cornell Medical College

Organizational unit: Schools & Hospitals

75

Houston Methodist Hospital

Organizational unit: Schools & Hospitals

70

Orthopedics & Sports Medicine

Organizational unit: Centers of Excellence

34

Cancer Center

Organizational unit: Centers of Excellence

19

Department of Surgery

Organizational unit: Departments

9
has Research OutputsResearch Output by Ennio Tasciotti

Shared Pub. External Organizations

Houston Methodist Research Institute

External organization: Unknown

42

Houston Methodist Hospital

External organization: Medical

28

University of Texas Health Science Center at Houston

External organization: Unknown

19

Univ. of Texas

External organization: Unknown

16

University of Texas M. D. Anderson Cancer Center

External organization: Unknown

12
has Research OutputsResearch Output by Ennio Tasciotti

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Ennio Tasciotti

Shared Pub. External co-authors

Jonathan O. Martinez

External person

29

Michael Evangelopoulos

External person

27

Silvia Minardi

External person

23

Iman K. Yazdi

External person

23

Ciro Chiappini

External person

17
has co-authored Research OutputsResearch Output with Ennio Tasciotti

ID: 2284603