Personal profile

Dr. Baskin began his research career while still a resident at the University of California San Francisco (UCSF). In 1982, he spent a year as a Research Associate at the University of Capetown Medical School and Groote Schuur Hospital in Capetown, South Africa. The following year, Dr. Baskin returned to UCSF and served as a Research Associate in the Hormone Research Laboratory. After completing his residency, Dr. Baskin was appointed as Assistant Professor of Neurological Surgery and Assistant Professor of the Center for Biotechnology at Baylor College of Medicine, with a joint appointment as Chief of Neurological Surgery at the VA Hospital. In 1994 he was promoted to Professor at Baylor College of Medicine in the departments of Neurosurgery and Anesthesiology, positions he held until 2005 when his academic career transitioned to Methodist.

Dr. Baskin has received many national and international honors and awards. He has served as principal investigator on numerous research projects funded by private, state and federal sources, resulting in multiple patents and patent applications. He has also chaired or served on review panels and advisory councils for private, state and federal agencies. Dr. Baskin has published over 100 scientific manuscripts and book chapters and currently serves as Program Director in Houston Methodist Neurological Institute, as well as Professor of Neurosurgery at Weill Cornell Medical College, and Research Professor at the University of Houston in both the Cullen College of Engineering's Department of Electrical and Computer Engineering and the School of Pharmacy.

Research interests

The long-term goals of the Neurosurgery Research Laboratory are to elucidate the DNA mechanisms in various types of neurological disease, and to develop novel diagnostics and treatments for primary brain tumors and autistic spectrum disorder. Dr. Baskin has recently developed methodologies to quantify the levels of different types of DNA damage and of labeled antibody staining in the field of fluorescence microscopy, using a new type of labeled tissue phantoms. His laboratory has introduced innovative techniques that allow the quantification of five different types of DNA damage; blunt ended breaks, overhanging breaks, 3'OH ends and nicks, 3'PO4 ends and nicks and also damaged/oxidized DNA bases. These techniques are in the process of being patented.

In addition, and in conjunction with these tools for examining DNA damage, his research group is pursuing mitochondrially targeted chemotherapeutic agents. These pro-drug agents are activated by enzyme systems known to be up-regulated in certain cancers. The active drug then attacks mitochondrial DNA and mitochondrial RNA; causing loss of mitochondria and cell death. In collaboration with Dr. James Tour, of the Smalley Institute for Nanoscale Science and Technology at Rice University, Dr. Baskin's group is investigating the use of nanoscale carbon clusters in numerous biomedical applications including as a means to deliver chemotherapeutic agents that are targeted specifically to cancer cells, as well as use as cellular protective agents.

The relationship between environmental pollutants and Autism is also a major research topic being pursued by Dr. Baskin and his group. They have been evaluating the role of possible causative agents, including the classical toxin, organic mercury, which he has shown to have high toxicity in a subgroup of autistic individuals. A second class of causative agents being investigated by his group are hormone disrupting agents such as the agro-chemicals DDT and Atrazine. Their preliminary data suggests that there is major difference in the response of cells from autistic individuals, compared to external controls.

Keywords

    Free-text keywords

  • Neurological surgery, Brain tumors, Stroke

    Research Area Keywords

  • Neurosciences
  • Clinical Care

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Opiate Alkaloids
Concept: Opiate Alkaloids
Weight: 100%
Domain: Medicine & Life Sciences
Brain Ischemia
Concept: Brain Ischemia
Weight: 92%
Domain: Medicine & Life Sciences
Glioblastoma
Concept: Glioblastoma
Weight: 87%
Domain: Medicine & Life Sciences
Naloxone
Concept: Naloxone
Weight: 85%
Domain: Medicine & Life Sciences
Pituitary Neoplasms
Concept: Pituitary Neoplasms
Weight: 70%
Domain: Medicine & Life Sciences
Spinal Cord Injuries
Concept: Spinal Cord Injuries
Weight: 58%
Domain: Medicine & Life Sciences
temozolomide
Concept: temozolomide
Weight: 49%
Domain: Medicine & Life Sciences
Evoked Potentials
Concept: Evoked Potentials
Weight: 47%
Domain: Medicine & Life Sciences
Glioma
Concept: Glioma
Weight: 46%
Domain: Medicine & Life Sciences
Therapeutics
Concept: Therapeutics
Weight: 45%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by David S. Baskin is tagged with the concept

Journals

Journal of Neurosurgery

ISSNs: 0022-3085

American Association of Neurological Surgeons

Journal

14

Neurosurgery.

ISSNs: 0148-396X

Additional searchable ISSN (Electronic): 1524-4040

Lippincott Williams and Wilkins

Journal

12

New England Journal of Medicine

ISSNs: 0028-4793, 1533-4406

Massachusetts Medical Society

Journal

5

Brain Research

ISSNs: 0006-8993

Elsevier

Journal

4

World Neurosurgery

ISSNs: 1878-8750

Elsevier

Journal

4
has published Research OutputsResearch Output by David S. Baskin

Research Network

Visualization: Institutional Network

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David S. Baskin

Visualization: Co-author Network

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David S. Baskin

Shared Pub. Internal Organizations

Stanley H. Appel Department of Neurology

Organizational unit: Departments

10

Department of Pathology & Genomic Medicine

Organizational unit: Departments

6

Department of Radiation Oncology

Organizational unit: Departments

5

Department of Medicine

Organizational unit: Departments

4

Center for Neuroregeneration

Organizational unit: Programs

3
has Research OutputsResearch Output by David S. Baskin

Shared Pub. External Organizations

Baylor College of Medicine

External organization: Unknown

48

Houston Methodist Research Institute

External organization: Unknown

28

Veterans Affairs Medical Center

External organization: Unknown

12

University of California, San Francisco

External organization: Unknown

11

University of California School of Medicine

External organization: Unknown

9
has Research OutputsResearch Output by David S. Baskin

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with David S. Baskin

Shared Pub. External co-authors

Yoshio Hosobuchi

External person

15

Marsha A. Widmayer

External person

14

Vladimir V. Didenko

External person

12

R. K. Simpson

External person

11

C. B. Wilson

External person

9
has co-authored Research OutputsResearch Output with David S. Baskin

ID: 2282223