Dr Huston received his MD from Wake Forest University School of Medicine and did his residency in Internal Medicine at Baylor College of Medicine. After completing his subspecialty training at the National Institutes of Health in 1980, Dr. Huston joined the faculty at the Baylor College of Medicine in Houston, Texas. While at Baylor, he became a full Professor of Medicine and Immunology, and held numerous leadership positions including the Cullen Chair of Immunology, the chief of the Immunology, Allergy, and Rheumatology Section, and director of the Immunology, Allergy, and Rheumatology Service at Houston Methodist Hospital. Dr. Huston also directed several training programs including the Allergy and Immunology Fellowship Training Program, the Clinical and Laboratory Immunology Fellowship Training Program, the Rheumatology Fellowship Training Program, the Translational Biology and Molecular Medicine Training Program in the Graduate School of Biomedical Sciences, and the Howard Hughes Medical Research Institute Grad into Med Program. 

He assumed his current positions at the Texas A&M Health Science Center Houston Campus in 2008, where he is Associate Dean for Physician Scientist Development, Professor of Microbial Pathogenesis and Immunology, Dr. Huston is also Director of the Academy of Physician Scientists, which is a collaborative program of Texas A&M and Houston Methodist to train medical students, residents, and early career faculty for careers as physician scientists. This collaborative program is one of only ten such programs in the nation supported by a Burroughs Wellcome Fund Physician Science Institutional Award. Dr. Huston has served on the Board of Directors for the American Board of Internal Medicine and the American Board of Allergy and Immunology, and on the Health and Public Policy Committee of the American Board of Medical Specialties, as well as the Board of Directors of the American Academy of Allergy Asthma and Immunology. He is a member of the American Association of Physicians and is consistently recognized as among the Best Doctors in America.

Dr. Huston’s research centers on the study of various mechanisms of allergic inflammation, utilizing basic science, pre-clinical, and clinical studies. He has been the principal investigator on several NIH grants, including an 11-year R01 from the National Institutes of Allergy and Infectious Diseases that defined the functional structure of Interleukin-5. Dr. Huston’s current studies investigate the role of human interleukin-3 in the development and maintenance of the Th2 immune response that dominates the allergic phenotype. Additional studies investigate the mechanisms of immune regulation in autoimmune and immune deficiency disorders.