Research outputs

  1. 2019
  2. Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies

    Beers, D. & Appel, S. H., Feb 1 2019, In : The Lancet Neurology. 18, 2, p. 211-220 10 p.

    Research output: Contribution to journalReview article

  3. Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brain

    Zanotti Fregonara, P., Pascual, M. B., Veronese, M., Yu, M. M., Beers, D., Appel, S. H. & Masdeu, J. C., Jan 1 2019, In : European Journal of Nuclear Medicine and Molecular Imaging.

    Research output: Contribution to journalArticle

  4. 2018
  5. Functional alterations of myeloid cells during the course of Alzheimer's disease

    Thome, A. D., Faridar, A., Beers, D. R., Thonhoff, J. R., Zhao, W., Wen, S., Pascual, B., Masdeu, J. C. & Appel, S. H., Nov 13 2018, In : Molecular Neurodegeneration. 13, 1, p. 61 1 p.

    Research output: Contribution to journalArticle

  6. Head-to-head comparison of 11C-PBR28 and 18F-GE180 for quantification of the translocator protein in the human brain

    Zanotti-Fregonara, P., Pascual, B., Rizzo, G., Yu, M., Pal, N., Beers, D., Carter, R., Appel, S. H., Atassi, N. & Masdeu, J. C., Aug 1 2018, In : Journal of Nuclear Medicine. 59, 8, p. 1260-1266 7 p.

    Research output: Contribution to journalArticle

  7. Expanded autologous regulatory T-lymphocyte infusions in ALS

    Thonhoff, J. R., Beers, D. R., Zhao, W., Pleitez, M., Simpson, E. P., Berry, J. D., Cudkowicz, M. E. & Appel, S. H., Jul 1 2018, In : Neurology - Neuroimmunology Neuroinflammation. 5, 4

    Research output: Contribution to journalArticle

  8. Expanded autologous regulatory T-lymphocyte infusions in ALS A phase I, first-in-human study

    Thonhoff, J. R., Beers, D. R., Zhao, W., Pleitez, M., Simpson, E. P., Berry, J. D., Cudkowicz, M. E. & Appel, S. H., Jul 1 2018, In : Neurology: Neuroimmunology and NeuroInflammation. 5, 4, p. e465 e465.

    Research output: Contribution to journalArticle

  9. The role of regulatory T lymphocytes in amyotrophic lateral sclerosis

    Beers, D., Zhao, W. & Appel, S. H., Jun 1 2018, In : JAMA Neurology. 75, 6, p. 656-658 3 p.

    Research output: Contribution to journalEditorial

  10. An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis

    Fournier, C. N., Schoenfeld, D., Berry, J. D., Cudkowicz, M. E., Chan, J., Quinn, C., Brown, R. H., Salameh, J. S., Tansey, M. G., Beers, D., Appel, S. H. & Glass, J. D., Jan 4 2018, (Accepted/In press) In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. p. 1-8 8 p.

    Research output: Contribution to journalArticle

  11. 2017
  12. Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes

    Zhao, W., Beers, D. R., Hooten, K. G., Sieglaff, D. H., Zhang, A., Kalyana-Sundaram, S., Traini, C. M., Halsey, W. S., Hughes, A. M., Sathe, G. M., Livi, G. P., Fan, G. H. & Appel, S. H., Jun 1 2017, In : JAMA Neurology. 74, 6, p. 677-685 9 p.

    Research output: Contribution to journalArticle

  13. ALS patients' regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity

    Beers, D. R., Zhao, W., Wang, J., Zhang, X., Wen, S., Neal, D., Thonhoff, J. R., Alsuliman, A. S., Shpall, E. J., Rezvani, K. & Appel, S. H., Mar 9 2017, In : JCI Insight. 2, 5, p. e89530

    Research output: Contribution to journalArticle

  14. 2016
  15. A robust, good manufacturing practice–compliant, clinical-scale procedure to generate regulatory T cells from patients with amyotrophic lateral sclerosis for adoptive cell therapy

    Alsuliman, A., Appel, S. H., Beers, D. R., Basar, R., Shaim, H., Kaur, I., Zulovich, J., Yvon, E., Muftuoglu, M., Imahashi, N., Kondo, K., Liu, E., Shpall, E. J. & Rezvani, K., Oct 1 2016, In : Cytotherapy. 18, 10, p. 1312-1324 13 p.

    Research output: Contribution to journalArticle

  16. 2015
  17. TDP-43 activates microglia through NF-κB and NLRP3 inflammasome

    Zhao, W., Beers, D. R., Bell, S., Wang, J., Wen, S., Baloh, R. H. & Appel, S. H., Nov 1 2015, In : Experimental Neurology. 273, p. 24-35 12 p.

    Research output: Contribution to journalArticle

  18. Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

    Hooten, K. G., Beers, D., Zhao, W. & Appel, S. H., Apr 1 2015, In : Neurotherapeutics. 12, 2, p. 364-375 12 p.

    Research output: Contribution to journalArticle

  19. The Role of Regulatory T Cells and Microglia in Amyotrophic Lateral Sclerosis

    Beers, D., Zhao, W., Hooten, K. G. & Appel, S. H., Mar 6 2015, Neuroinflammation: New Insights into Beneficial and Detrimental Functions. David, S. (ed.). Wiley, p. 235-249 15 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  20. 2014
  21. Role of Inflammation in Neurodegenerative Diseases

    Appel, S. H., Beers, D. & Zhao, W., Dec 3 2014, Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. Elsevier, p. 380-395 16 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  22. Neuroimmunology of Amyotrophic Lateral Sclerosis

    Henkel, J. S., Beers, D., Zhao, W. & Appel, S. H., Jun 3 2014, Neuroinflammation and CNS Disorders. Wiley, p. 185-209 25 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  23. 2013
  24. Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis

    Zhao, W., Beers, D. & Appel, S. H., Sep 1 2013, In : Journal of Neuroimmune Pharmacology. 8, 4, p. 888-899 12 p.

    Research output: Contribution to journalArticle

  25. Erratum: Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival [EMBO Mol Med 5, 1] DOI: 10.1002/emmm.201201544

    Henkel, J. S., Beers, D., Wen, S., Rivera, A. L., Toennis, K. M., Appel, J. E., Zhao, W., Moore, D. H., Powell, S. Z-E. & Appel, S. H., Feb 1 2013, In : EMBO Molecular Medicine. 5, 2

    Research output: Contribution to journalArticle

  26. Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival

    Henkel, J. S., Beers, D., Wen, S., Rivera, A. L., Toennis, K. M., Appel, J. E., Zhao, W., Moore, D. H., Powell, S. Z-E. & Appel, S. H., Jan 1 2013, In : EMBO Molecular Medicine. 5, 1, p. 64-79 16 p.

    Research output: Contribution to journalArticle

  27. 2012
  28. Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms

    Zhao, W., Beers, D., Liao, B., Henkel, J. S. & Appel, S. H., Dec 1 2012, In : Neurobiology of Disease. 48, 3, p. 418-428 11 p.

    Research output: Contribution to journalArticle

  29. Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS

    Liao, B., Zhao, W., Beers, D., Henkel, J. S. & Appel, S. H., Sep 1 2012, In : Experimental Neurology. 237, 1, p. 147-152 6 p.

    Research output: Contribution to journalArticle

  30. Reactive oxygen and nitrogen species - A driving force in amyotrophic lateral sclerosis

    Henkel, J. S., Beers, D., Zhao, W. & Appel, S. H., May 1 2012, Systems Biology of Free Radicals and Antioxidants. Springer-Verlag Berlin Heidelberg, p. 3141-3165 25 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  31. Peripheral nerve inflammation in als mice: Cause or consequence

    Kano, O., Beers, D., Henkel, J. S. & Appel, S. H., Mar 13 2012, In : Neurology. 78, 11, p. 833-835 3 p.

    Research output: Contribution to journalArticle

  32. 2011
  33. Excess circulating alternatively activated myeloid (M2) cells accelerate ALS progression while inhibiting experimental autoimmune encephalomyelitis

    Vaknin, I., Kunis, G., Miller, O., Butovsky, O., Bukshpan, S., Beers, D. R., Henkel, J. S., Yoles, E., Appel, S. H. & Schwartz, M., Nov 3 2011, In : PLoS ONE. 6, 11, e26921.

    Research output: Contribution to journalArticle

  34. Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice

    Beers, D., Zhao, W., Liao, B., Kano, O., Wang, J., Huang, A., Appel, S. H. & Henkel, J. S., Jul 1 2011, In : Brain, Behavior, and Immunity. 25, 5, p. 1025-1035 11 p.

    Research output: Contribution to journalArticle

  35. The microglial-motoneuron dialogue in ALS

    Appel, S. H., Zhao, W., Beers, D. & Henkel, J. S., Jun 1 2011, In : Acta Myologica. 30, JUNE, p. 4-8 5 p.

    Research output: Contribution to journalArticle

  36. Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

    Beers, D., Henkel, J. S., Zhao, W., Wang, J., Huang, A., Wen, S., Liao, B. & Appel, S. H., May 1 2011, In : Brain. 134, 5, p. 1293-1314 22 p.

    Research output: Contribution to journalArticle

  37. 2010
  38. Extracellular mutant SOD1 induces microglial-mediated motoneuron injury

    Zhao, W., Beers, D., Henkel, J. S., Zhang, W., Urushitani, M., Julien, J. P. & Appel, S. H., Jan 6 2010, In : GLIA. 58, 2, p. 231-243 13 p.

    Research output: Contribution to journalArticle

  39. T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

    Appel, S. H., Beers, D. & Henkel, J. S., Jan 1 2010, In : Trends in Immunology. 31, 1, p. 7-17 11 p.

    Research output: Contribution to journalArticle

  40. 2009
  41. Microglia in ALS: The good, the bad, and the resting

    Henkel, J. S., Beers, D., Zhao, W. & Appel, S. H., Dec 1 2009, In : Journal of Neuroimmune Pharmacology. 4, 4, p. 389-398 10 p.

    Research output: Contribution to journalArticle

  42. Decreased mRNA expression of tight junction proteins in lumbar spinal cords of patients with ALS

    Henkel, J. S., Beers, D., Wen, S., Bowser, R. & Appel, S. H., May 5 2009, In : Neurology. 72, 18, p. 1614-1616 3 p.

    Research output: Contribution to journalArticle

  43. 2008
  44. Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis

    Appel, S. H., Engelhardt, J. I., Henkel, J. S., Siklos, L., Beers, D. R., Yen, A. A., Simpson, E. P., Luo, Y., Carrum, G., Heslop, H. E., Brenner, M. K. & Popat, U., Oct 21 2008, In : Neurology. 71, 17, p. 1326-1334 9 p.

    Research output: Contribution to journalArticle

  45. CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

    Beers, D., Henkel, J. S., Zhao, W., Wang, J. & Appel, S. H., Oct 7 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 40, p. 15558-15563 6 p.

    Research output: Contribution to journalArticle

  46. Novel therapeutic targets in neurodegenerative diseases: lessons from amyotrophic lateral sclerosis.

    Appel, S. H., Beers, D., Henkel, J. S. & Zhao, W., Sep 1 2008, In : Current neurology and neuroscience reports. 8, 5, p. 353-355 3 p.

    Research output: Contribution to journalArticle

  47. 2007
  48. Mutant SOD1G93A microglia are more neurotoxic relative to wild-type microglia

    Xiao, Q., Zhao, W., Beers, D., Yen, A. A., Xie, W., Henkel, J. S. & Appel, S. H., Sep 1 2007, In : Journal of Neurochemistry. 102, 6, p. 2008-2019 12 p.

    Research output: Contribution to journalArticle

  49. 2006
  50. Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia

    Zhao, W., Xie, W., Xiao, Q., Beers, D. & Appel, S. H., Nov 1 2006, In : Journal of Neurochemistry. 99, 4, p. 1176-1187 12 p.

    Research output: Contribution to journalArticle

  51. Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

    Beers, D., Henkel, J. S., Xiao, Q., Zhao, W., Wang, J., Yen, A. A., Siklos, L., McKercher, S. R. & Appel, S. H., Oct 24 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 43, p. 16021-16026 6 p.

    Research output: Contribution to journalArticle

  52. The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS

    Henkel, J. S., Beers, D. R., Siklós, L. & Appel, S. H., Mar 1 2006, In : Molecular and Cellular Neuroscience. 31, 3, p. 427-437 11 p.

    Research output: Contribution to journalArticle

  53. 2004
  54. Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism

    Zhao, W., Xie, W., Le, W., Beers, D., He, Y., Henkel, J. S., Simpson, E. P., Yen, A. A., Xiao, Q. & Appel, S. H., Sep 1 2004, In : Journal of neuropathology and experimental neurology. 63, 9, p. 964-977 14 p.

    Research output: Contribution to journalArticle

  55. HFE mutations are not strongly associated with sporadic ALS

    Yen, A. A., Simpson, E. P., Henkel, J. S., Beers, D. & Appel, S. H., May 11 2004, In : Neurology. 62, 9, p. 1611-1612 2 p.

    Research output: Contribution to journalArticle

  56. Presence of Dendritic Cells, MCP-1, and Activated Microglia/Macrophages in Amyotrophic Lateral Sclerosis Spinal Cord Tissue

    Henkel, J. S., Engelhardt, J. I., Siklós, L., Simpson, E. P., Kim, S. H., Pan, T., Goodman, J. C., Siddique, T., Beers, D. R. & Appel, S. H., Feb 1 2004, In : Annals of Neurology. 55, 2, p. 221-235 15 p.

    Research output: Contribution to journalArticle

  57. 2003
  58. PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients

    Kim, S. H., Henkel, J. S., Beers, D. R., Sengun, I. S., Simpson, E. P., Goodman, J. C., Engelhardt, J. I., Siklós, L. & Appel, S. H., Jan 1 2003, In : Journal of neuropathology and experimental neurology. 62, 1, p. 88-103 16 p.

    Research output: Contribution to journalArticle

  59. 2002
  60. Immunoglobulin Fcγ receptor promotes immunoglobulin uptake, immunoglobulin-mediated Calcium increase, and neurotransmitter release in motor neurons

    Mohamed, H. A., Mosier, D. R., Zou, L. L., Siklós, L., Alexianu, M. E., Engelhardt, J. I., Beers, D., Le, W. & Appel, S. H., Jul 1 2002, In : Journal of Neuroscience Research. 69, 1, p. 110-116 7 p.

    Research output: Contribution to journalArticle

  61. 2001
  62. Parvalbumin overexpression alters immune-mediated increases in intracellular calcium, and delays disease onset in a transgenic model of familial amyotrophic lateral sclerosis

    Beers, D., Ho, B. K., Siklós, L., Alexianu, M. E., Mosier, D. R., Habib Mohamed, A., Otsuka, Y., Kozovska, M. E., McAlhany, R. E., Glenn Smith, R. & Appel, S. H., Nov 14 2001, In : Journal of Neurochemistry. 79, 3, p. 499-509 11 p.

    Research output: Contribution to journalArticle

  63. Calcium: The Darth Vader of ALS

    Appel, S. H., Beers, D., Siklos, L., Engelhardt, J. I. & Mosier, D. R., Mar 1 2001, In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 2, SUPPL. 1

    Research output: Contribution to journalArticle

  64. 2000
  65. Altered calcium homeostasis in ALS as a target for therapy

    Appel, S. H., Beers, D., Smith, R. G. & Wilson, J. E., Dec 1 2000, In : Amyotrophic Lateral Sclerosis. 1, 4, p. 27-32 6 p.

    Research output: Contribution to journalArticle

  66. 1998
  67. Role of potassium channels in amyloid-induced cell death

    Colom, L. V., Diaz, M. E., Beers, D., Neely, A., Xie, W. J. & Appel, S. H., May 1 1998, In : Journal of Neurochemistry. 70, 5, p. 1925-1934 10 p.

    Research output: Contribution to journalArticle

  68. 1995
  69. Cloning and restriction endonuclease mapping of herpes simplex virus type-1 strains H129 and +GC

    Kienzle, T. E., Henkel, J. S., Ling, J. Y., Banks, M. C., Beers, D., Jones, B. & Stroop, W. G., Sep 1 1995, In : Archives of Virology. 140, 9, p. 1663-1675 13 p.

    Research output: Contribution to journalArticle

  70. Spatial recognition memory deficits without notable CNS pathology in rats following herpes simplex encephalitis

    Beers, D., Henkel, J. S., Kesner, R. P. & Stroop, W. G., Aug 1 1995, In : Journal of the neurological sciences. 131, 2, p. 119-127 9 p.

    Research output: Contribution to journalArticle

  71. 1993
  72. Neuropathology of herpes simplex virus encephalitis in a rat seizure model

    Beers, D., Henkel, J. S., Schaefer, D. C., Rose, J. W. & Stroop, W. G., May 1 1993, In : Journal of neuropathology and experimental neurology. 52, 3, p. 241-252 12 p.

    Research output: Contribution to journalArticle

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