Projects per year
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Research Area Keywords
- Neurosciences
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Collaborations and top research areas from the last five years
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A Study of Biological Markers for the Nervous and Immune Systems and Free Radical Mediated Processes in Amyotrophic Lateral Sclerosis (ALS)
Appel, S. H. (PI), Beers, D. (Key Personnel), Greene, E. P. (Key Personnel), Lai, E. C. (Key Personnel), Liao, B. (Key Personnel), Shroff, S. (Key Personnel) & Zhao, W. (Key Personnel)
8/13/20 → …
Project: Clinical Trial
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Immune Mechanisms in Amyotrophic Lateral Sclerosis
Appel, S. H. (PI), Beers, D. (Project Director) & Zhao, W. (Project Director)
Muscular Dystrophy Association
5/1/14 → 4/30/17
Project: Non Profit
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Blocking TLR-Activation of Regulatory T cells Slows Disease in ALS
Appel, S. H. (PI), Beers, D. (CoI) & Zhao, W. (CoI)
Natl Inst of Neuro Disorders and Stroke
3/15/13 → 8/31/15
Project: Federal Funding Agencies
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Using CD4+T Cells as a candidate therapy to slow disease progression in ALS
Appel, S. H. (PI), Beers, D. (CoI) & Zhao, W. (CoI)
Natl Inst of Neuro Disorders and Stroke
2/15/10 → 4/30/12
Project: Federal Funding Agencies
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Low-dose interleukin-2 in patients with mild to moderate Alzheimer's disease: a randomized clinical trial
Faridar, A., Gamez, N., Li, D., Wang, Y., Boradia, R., Thome, A. D., Zhao, W., Beers, D. R., Thonhoff, J. R., Nakawah, M. O., Román, G. C., Volpi, J. J., Toledo, J. B., George, M., Davis, C. S., Pascual, B., Grundman, M., Masdeu, J. C. & Appel, S. H., Jul 4 2025, In: Alzheimer's Research and Therapy. 17, 1, p. 146Research output: Contribution to journal › Article › peer-review
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A phase 1 proof-of-concept study evaluating safety, tolerability, and biological marker responses with combination therapy of CTLA4-Ig and interleukin-2 in amyotrophic lateral sclerosis
Thonhoff, J. R., Beers, D. R., Zhao, W., Faridar, A., Thome, A., Wen, S., Zhang, A., Wang, J. & Appel, S. H., 2024, In: Frontiers in Neurology. 15, p. 1415106 1415106.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer’s disease
Faridar, A., Eid, A. M., Thome, A. D., Zhao, W., Beers, D. R., Pascual, M. B., Nakawah, M. O., Roman, G. C., Davis, C. S., Grundman, M., Masdeu, J. C. & Appel, S. H., Nov 16 2023, In: Translational Neurodegeneration. 12, 1, p. 54 54.Research output: Contribution to journal › Letter › peer-review
Open Access14 Scopus citations -
Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral Sclerosis
Thonhoff, J. R., Berry, J. D., Macklin, E. A., Beers, D. R., Mendoza, P. A., Zhao, W., Thome, A. D., Triolo, F., Moon, J. J., Paganoni, S., Cudkowicz, M. & Appel, S. H., Nov 29 2022, In: Neurology: Neuroimmunology and NeuroInflammation. 9, 6, e200019.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
Extracellular Vesicles Derived From Ex Vivo Expanded Regulatory T Cells Modulate In Vitro and In Vivo Inflammation
Thome, A. D., Thonhoff, J. R., Zhao, W., Faridar, A., Wang, J., Beers, D. R. & Appel, S. H., Jun 22 2022, In: Frontiers in immunology. 13, p. 875825 875825.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations