Dale J. Hamilton, MD

Personal profile

Dr. Hamilton’s professional career tract has provided the expertise, leadership, and experience to direct the Center for Bioenergetics at Houston Methodist Research Institute. His education was in cellular molecular biology and medicine, and post-graduate training in medicine and endocrinology, as well as laboratory research. His early professional career combined clinical practice and graduate medical education. The transition to translational research began in 2002 when he formed collaborations with colleagues involving clinical treatment trials and orthotopic human islet transplantation. By 2006 his research focus had narrowed to translational issues related to mitochondrial substrate oxidation and energy transfer in failing organ systems such as the human heart.

Research interests

In 2013, Dr. Hamilton established a bioenergetic research initiative at Houston Methodist Research Institute with the objective of identifying mechanisms of altered energy transduction in disease states, especially those involving high energy tissues. Early and ongoing investigations focus on myocardial energetics in the failing heart. Evolving projects now include the mechanistic study of energy strategies in neoplasia and bioenergetic changes associated with estrogen deficiency. A recent novel but growing project addresses the challenge of transferring functional mitochondria into energy altered tissue such as the failing cardiomyocyte or growing neoplastic cell. The investigative methods include the use of pre-clinical models, tissue cultures and human tissue for analysis. Oxygen consumption, respiratory coupling and glycolytic energy transfer using genomics, metabolomic and proteomic methods are also studied. The team includes basic science specialists in biochemistry and cell biology as well as clinical investigators in cardiology, endocrinology and cardiothoracic surgery. These results have been communicated to the local and national scientific community; positive feedback on these results has strengthened the lab’s ability to design a realistic research plan.

Keywords

    Research Area Keywords

  • Clinical Translation & Trials
  • Molecular Medicine

    Free-text keywords

  • Bioenergetics & Molecular Medicine, Diabetes, Endocrine disorders, Diabetic complications

External positions

Adjunct Research Professor, University of Houston

Fingerprint

Heart Failure
Concept: Heart Failure
Weight: 100%
Domain: Medicine & Life Sciences
Heart Transplantation
Concept: Heart Transplantation
Weight: 47%
Domain: Medicine & Life Sciences
Mitochondria
Concept: Mitochondria
Weight: 40%
Domain: Medicine & Life Sciences
Islets of Langerhans
Concept: Islets of Langerhans
Weight: 38%
Domain: Medicine & Life Sciences
Inflammation
Concept: Inflammation
Weight: 38%
Domain: Medicine & Life Sciences
Insulin Resistance
Concept: Insulin Resistance
Weight: 33%
Domain: Medicine & Life Sciences
Immunosuppressive Agents
Concept: Immunosuppressive Agents
Weight: 26%
Domain: Medicine & Life Sciences
Obesity
Concept: Obesity
Weight: 26%
Domain: Medicine & Life Sciences
Glycine
Concept: Glycine
Weight: 26%
Domain: Medicine & Life Sciences
Myocardium
Concept: Myocardium
Weight: 26%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Dale J. Hamilton is tagged with the concept

Journals

Methodist DeBakey Cardiovascular Journal

ISSNs: 1947-6094

Additional searchable ISSN (Electronic): 1947-6108

Methodist DeBakey Heart & Vascular Center, United States

Journal

11

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

ISSNs: 1079-5006

Oxford University Press

Journal

2

Cell Metabolism

ISSNs: 1550-4131

Cell Press

Journal

2

Cardiology (Switzerland)

ISSNs: 0008-6312

Additional searchable ISSN (Electronic): 1421-9751

S. Karger AG

Scopus rating (2018): CiteScore 1.25 SJR 0.837 SNIP 0.525

Journal

2

Journal of Diabetes Research

ISSNs: 2314-6745

Additional searchable ISSN (Electronic): 2314-6753

Hindawi Publishing Corporation

Scopus rating (2018): CiteScore 3.02 SJR 1.145 SNIP 1.075

Journal

1
has published Research OutputsResearch Output by Dale J. Hamilton

Research Network

Visualization: Institutional Network

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Dale J. Hamilton

Visualization: Co-author Network

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Dale J. Hamilton

Shared Pub. Internal Organizations

DeBakey Heart & Vascular Center

Organizational unit: Centers of Excellence

10

Department of Cardiology

Organizational unit: Departments

8

Department of Cardiovascular Sciences

Organizational unit: Departments

8

J.C. Walter Jr. Transplant Center

Organizational unit: Centers of Excellence

7

Center for Cardiovascular Regeneration

Organizational unit: Programs

6
has Research OutputsResearch Output by Dale J. Hamilton

Shared Pub. External Organizations

Houston Methodist Research Institute

External organization: Unknown

13

Baylor College of Medicine

External organization: Unknown

4

Medical School

External organization: Unknown

3

Weill Medical College of Cornell University

External organization: Unknown

3

Methodist DeBakey Heart and Vascular Center

External organization: Unknown

3
has Research OutputsResearch Output by Dale J. Hamilton

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Dale J. Hamilton

Shared Pub. External co-authors

Christopher J. Lyon

External person

5

Willa A. Hsueh

External person

5

A. M. Cordero-Reyes

External person

5

Shumin Li

External person

4

Laurie J. Minze

External person

3
has co-authored Research OutputsResearch Output with Dale J. Hamilton

ID: 2287622