Projects per year
Personal profile
Personal profile
Dr. Hamilton’s professional career tract has provided the expertise, leadership, and experience to direct the Center for Bioenergetics at Houston Methodist Research Institute. His education was in cellular molecular biology and medicine, and post-graduate training in medicine and endocrinology, as well as laboratory research. His early professional career combined clinical practice and graduate medical education. The transition to translational research began in 2002 when he formed collaborations with colleagues involving clinical treatment trials and orthotopic human islet transplantation. By 2006 his research focus had narrowed to translational issues related to mitochondrial substrate oxidation and energy transfer in failing organ systems such as the human heart.
Research interests
In 2013, Dr. Hamilton established a bioenergetic research initiative at Houston Methodist Research Institute with the objective of identifying mechanisms of altered energy transduction in disease states, especially those involving high energy tissues. Early and ongoing investigations focus on myocardial energetics in the failing heart. Evolving projects now include the mechanistic study of energy strategies in neoplasia and bioenergetic changes associated with estrogen deficiency. A recent novel but growing project addresses the challenge of transferring functional mitochondria into energy altered tissue such as the failing cardiomyocyte or growing neoplastic cell. The investigative methods include the use of pre-clinical models, tissue cultures and human tissue for analysis. Oxygen consumption, respiratory coupling and glycolytic energy transfer using genomics, metabolomic and proteomic methods are also studied. The team includes basic science specialists in biochemistry and cell biology as well as clinical investigators in cardiology, endocrinology and cardiothoracic surgery. These results have been communicated to the local and national scientific community; positive feedback on these results has strengthened the lab’s ability to design a realistic research plan.
Education/Academic qualification
Endocrinology, Diabetes & Metabolism, Clinical Fellowship, Baylor College of Medicine
Jul 1 1981 → Jun 30 1983
Award Date: Jun 30 1983
Internal Medicine, Residency, Baylor College of Medicine
Jun 24 1978 → Jun 30 1981
Award Date: Jun 30 1981
MD, Saint Louis University
… → May 13 1978
Award Date: May 13 1978
External positions
Adjunct Research Professor, University of Houston
Research Area Keywords
- Clinical Translation & Trials
- Molecular Medicine
Free-text keywords
- Bioenergetics & Molecular Medicine
- Diabetes
- Endocrine disorders
- Diabetic complications
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Defining the altered FUS-PARP-1-DNA Ligase III axis and its implications to nuclear and mitochondrial genome damage response in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)
Hegde, M., Hamilton, D. J., Horner, P. J. & Mitra, J.
4/15/20 → 3/31/25
Project: Federal Funding Agencies
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X-linked Hypophosphatemia Disease Monitoring Program (XLH-DMP)
Project: Clinical Trial
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Mitochondrial transplantation as a strategy to metabolically reprogram macrophages in atherosclerotic lesions
7/1/19 → 6/30/22
Project: Non Profit
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Mitochondrial transplantation: a novel therapy for lung fibrosis
6/1/19 → 11/30/22
Project: Federal Funding Agencies
Research output
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The efficacy and safety of burosumab in two patients with cutaneous skeletal hypophosphatemia syndrome
Sugarman, J., Maruri, A., Hamilton, D. J., Tabatabai, L., Luca, D., Cimms, T., Krolczyk, S., Roberts, M. S. & Carpenter, T. O., Jan 2023, In: Bone. 166, 116598.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
AIBP Regulates Metabolism of Ketone and Lipids but Not Mitochondrial Respiration
Kim, J. D., Zhou, T., Zhang, A., Li, S., Gupte, A. A., Hamilton, D. J. & Fang, L., Nov 2022, In: Cells. 11, 22, 3643.Research output: Contribution to journal › Article › peer-review
Open Access -
Dynamic Tumor-Specific MHC-II Immuno-PET Predicts the Efficacy of Checkpoint Inhibitor Immunotherapy in Melanoma
Yang, Z., Li, F., Huang, Y., Yin, N., Chu, J., Ma, Y., Pettigrew, R. I., Hamilton, D. J., Martin, D. R. & Li, Z., Nov 1 2022, In: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 63, 11, p. 1708-1714 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Enhanced Succinate Oxidation with Mitochondrial Complex II Reactive Oxygen Species Generation in Human Prostate Cancer
Zhang, A., Gupte, A. A., Chatterjee, S., Li, S., Ayala, A., Miles, B. J. & Hamilton, D. J., Oct 12 2022, In: International journal of molecular sciences. 23, 20, p. 12168 12168.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Polymer-Functionalized Mitochondrial Transplantation to Plaque Macrophages as a Therapeutic Strategy Targeting Atherosclerosis
Liu, H., Wu, S., Lee, H., Baudo, G., Massaro, M., Zhang, A., Hamilton, D. J. & Blanco, E., May 2022, In: advanced therapeutics. 5, 5, 2100232.Research output: Contribution to journal › Article › peer-review
Open Access
Prizes
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1st place Poster award, Kostas meeting
Huang, Y. (Recipient), Yang, Z. (Recipient), Li, F. (Recipient), Hamilton, Dale J. (Recipient) & Li, Z. (Recipient), 2019
Prize: Prize (including medals and awards)
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1st place research award, Society of Chinese American Nuclear Medicine and Molecular Imaging
Yang, Z. (Recipient), Li, F. (Recipient), Hamilton, Dale J. (Recipient) & Li, Z. (Recipient), 2019
Prize: Prize (including medals and awards)
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Kostas meeting, shark tank second place
Yang, Z. (Recipient), Li, F. (Recipient), Pownall, H. (Recipient), Hamilton, Dale J. (Recipient) & Li, Z. (Recipient), 2019
Prize: Prize (including medals and awards)
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Poster Award
Yang, Z. (Recipient), Li, F. (Recipient), Li, Z. (Recipient) & Hamilton, Dale J. (Recipient), 2018
Prize: Prize (including medals and awards)
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The 3rd Place Poster Award, 2020 MAPTA’s 3rd Annual Summer Science Symposium
Zhang, H. (Recipient), Zhang, Aijun (Recipient), Gupte, Anisha A. (Recipient) & Hamilton, Dale J. (Recipient), 2020
Prize: Prize (including medals and awards)