Projects per year
Personal profile
Personal profile
Dr. Rosales’ doctoral training is in Pathology and Molecular Biology, earning her degree at the University of Texas-Houston. Her graduate research studies involved engineering a mouse model for lipid metabolism and resulted in a first author paper showing that the cluster of differentiation-1d (CD1d) is a cell surface receptor for oxysterol-induced PPAR-gamma(γ) activation.
In her postdoctoral fellowship at Baylor College of Medicine she acquired expertise in lipoprotein isolation and analysis, lipid synthesis, enzymatic assays, in vivo methods, and chemical kinetics using fluorescence spectroscopy, radiolabeling, and turbidimetric kinetics. Dr. Rosales’ current research studies are focused on a streptococcal protein, serum opacity factor (SOF), which catalyzes a novel reaction that targets plasma HDL. She was part of a team that showed that SOF destabilizes and selectively delipidates human HDL by a mechanism that yields an apo E-containing, cholesteryl ester-rich microemulsion (CERM), lipid-free (LF) apo AI and a phospholipid-rich “neo HDL”.
Dr. Rosales has continued to work on SOF uncovering the stabilizing role of apo AII in modulating the SOF reaction. She has carried out experiments revealing the cardioprotective potential of SOF; she led the in vivo studies which showed that low dose SOF (4 µg) reduces plasma cholesterol in WT mice ~45% in three hours where it remains for 20 hours. Using wild-type, apo E-null, and LDLR-null mice, she then showed that the reduction in plasma cholesterol was mediated by apo E, which directed the CERM to several apo E-dependent receptors, including LDLR. Subsequently, her studies of SOF vs. HDL from apo AI-null mice further showed that HDL instability and apo AI lability are permitting factors in the SOF reaction.
Future studies in her lab involve determining the role of SOF in the prevention and/or regression of atherosclerosis. A recently funded clinical grant will also be examining HDL function in patients with high HDL profiles from the cardiology clinic. Dr. Rosales is, also, pursuing studies in fertility after a novel discovery that SOF can reverse fertility in SRBI knockout mice, which are a model of high plasma HDL.
Dr. Rosales is currently an assistant professor in the Department of Medicine and director of the Summer Undergraduate Research Internship program. She enjoys mentoring and interacting with students and giving didactic lectures.
External positions
Associate Professor of Molecular Biology Research in Medicine, Weill Cornell Medical College
Jan 1 2016 → …
Research Area Keywords
- Heart & Vascular
Free-text keywords
- Serum opacity factor
- Lipoproteins
- Cholesterol metabolism
- HDL
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Collaborations and top research areas from the last five years
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Dysfunctional High Density Lipoprotein Free Cholesterol Bioavailability and Atherogenesis
Pownall, H. J. (PI), Gillard, B. K. (Key Personnel), Nasir, K. (Key Personnel), Patel, K. V. (Key Personnel) & Rosales, C. (Key Personnel)
3/21/24 → …
Project: Clinical Trial
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Atheroprotection via Reduced Plasma High Density Lipoprotein-Free Cholesterol Bioavailability
Pownall, H. J. (PI), Rosales, C. (PI) & Gillard, B. K. (Key Personnel)
12/1/19 → 11/30/24
Project: Federal Funding Agencies
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High Density Lipoprotein Biogenesis and Speciation
Pownall, H. J. (PI), Rosales, C. (PI) & Gillard, B. K. (Key Personnel)
National Heart Lung and Blood Institute
8/1/16 → 5/31/21
Project: Federal Funding Agencies
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HDL-free cholesterol influx into macrophages and transfer to LDL correlate with HDL-free cholesterol content
Yelamanchili, D., Gillard, B. K., Gotto, A. M., Achirica, M. C., Nasir, K., Remaley, A. T., Rosales, C. & Pownall, H. J., Jan 2025, In: Journal of lipid research. 66, 1, p. 100707 100707.Research output: Contribution to journal › Article › peer-review
Open Access -
Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer’s disease
Hori, A., Inaba, H., Hato, T., Tanaka, K., Sato, S., Okamoto, M., Horiuchi, Y., Paran, F. J., Tabe, Y., Mori, S., Rosales, C., Akamatsu, W., Murayama, T., Kurebayashi, N., Sakurai, T., Ai, T. & Miida, T., Aug 1 2024, In: PLoS ONE. 19, 8 August, e0291887.Research output: Contribution to journal › Article › peer-review
Open Access -
Serum Opacity Factor Normalizes Erythrocyte Morphology in Scarb1-/- Mice in an HDL-Free Cholesterol-Dependent Way.
Wang, Z., Yelamanchili, D., Liu, J., Gotto, A. M., Rosales, C., Gillard, B. K. & Pownall, H. J., Nov 2023, In: Journal of lipid research. 64, 11, p. 100456 100456.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Serum opacity factor rescues fertility among female Scarb1−/− mice by reducing HDL-free cholesterol bioavailability
Rosales, C., Yelamanchili, D., Gillard, B. K., Liu, J., Gotto, A. M. & Pownall, H. J., Feb 2023, In: Journal of lipid research. 64, 2, p. 100327 100327.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
The pathophysiology of excess plasma-free cholesterol
Gillard, B. K., Rosales, C., Gotto, A. M. & Pownall, H. J., Dec 1 2023, In: Current opinion in lipidology. 34, 6, p. 278-286 9 p., PMID: 37732779.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations
Prizes
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American Heart Association (AHA) Basic Cardiovascular Sciences Minority Travel Grant
Rosales, C. (Recipient), 2007
Prize: Prize (including medals and awards)
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Deuel Conference Travel Award
Rosales, C. (Recipient), 2011
Prize: Prize (including medals and awards)
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FASEB MARC Program Minority Trainee Travel Award
Rosales, C. (Recipient), 2005
Prize: Prize (including medals and awards)
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FASEB MARC Program Poster Travel Award
Rosales, C. (Recipient), 2003
Prize: Prize (including medals and awards)
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First Place Poster- Research Day: New Pathways to Discovery-Leaders in Innovation
Rosales, C. (Recipient), 2007
Prize: Prize (including medals and awards)