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My laboratory has two decades of experience in investigating the immunological mechanisms of vaccine and adjuvants against infectious diseases with an emphasis on tuberculosis. Tuberculosis kills more infants and adults (~ 1.5 million) than any infectious agent each year. We use genetic, and immunological engineering to develop new generation bacterial, subunit, replication deficient viral and mRNA vaccines for protection against TB. We use mouse, humanized mouse and macaque models to test and validate our vaccines and use cutting edge techniques like RNAseq, single cell RNAseq, single cell proteomics (MILO), single cell metabolomics (Isoplexis) followed by functional assays to understand mouse and human immune system. Strengthening of the infant immune system is major focus of our research. A rotation in my lab provides training in using cell culture and animal model-based methods to test the Systems Immunobiology of mouse and human-immune system.

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1981 …2024

Research activity per year

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