Chinnaswamy Jagannath

Accepting PhD Students

PhD projects

My laboratory has two decades of experience in investigating the immunological mechanisms of vaccine and adjuvants against infectious diseases with an emphasis on tuberculosis. Tuberculosis kills more infants and adults (~ 1.5 million) than any infectious agent each year. We use genetic, and immunological engineering to develop new generation bacterial, subunit, replication deficient viral and mRNA vaccines for protection against TB. We use mouse, humanized mouse and macaque models to test and validate our vaccines and use cutting edge techniques like RNAseq, single cell RNAseq, single cell proteomics (MILO), single cell metabolomics (Isoplexis) followed by functional assays to understand mouse and human immune system. Strengthening of the infant immune system is major focus of our research. A rotation in my lab provides training in using cell culture and animal model-based methods to test the Systems Immunobiology of mouse and human-immune system.

h-index

Research activity per year

3 Active
5 Finished

8 results

Active

Sirtuin -Dependent Regulation of Tuberculosis and HIV Interactions in Macrophages
Jagannath, C.
8/1/24 → 7/31/29
Project: Federal Funding Agencies
A novel hyper-immunogenic low virulent BCG vaccine against tuberculosis
Jagannath, C.
2/3/23 → 1/31/28
Project: Federal Funding Agencies
Novel Stem Cell Immunotherapy for MDR-Tuberculosis
Jagannath, C.
6/4/21 → 5/31/26
Project: Federal Funding Agencies
Finished

Role of Metabolic Me-Macrophages in the Pathogenesis of Tuberculosis during Diabetes
Jagannath, C.
3/1/21 → 2/28/23
Project: Federal Funding Agencies
Evaluation of immune responses to CD44-targeted nanovectors for designing a novel anti-tuberculosis host-directed therapy
Godin, B., Jagannath, C. & Leonard, F.
5/1/20 → 10/31/22
Project: Federal Funding Agencies
A Neonatal Monkey Model of Tuberculosis Vaccination
Jagannath, C.
6/1/19 → 5/31/23
Project: Federal Funding Agencies
SigH based attenuated, efficacious Mtb vaccines to protect against lethal TB
Jagannath, C.
5/1/19 → 4/30/24
Project: Federal Funding Agencies
Mesenchymal Stem Cell Niche for Tuberculosis
Jagannath, C.
2/1/19 → 1/31/21
Project: Federal Funding Agencies

Chinnaswamy Jagannath, PhD

Projects

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