Personal profile

Arshad Khan received a PhD in Biotechnology from the University of Pune, Pune, India in September 2009. Following a post-doctoral fellowship in Pathology and Laboratory Medicine at the University of Texas Health Science Center’s McGovern School of Medicine, Dr. Khan was appointed as Assistant Professor of Pathology there in March 2016, with his research focusing on class I and Class II (MHC-I and MHC-II) antigen presentation of bacillus Calmette-Guerin (BCG) in order to improve the efficacy of the BCG vaccine against Mycobacterium tuberculosis

Dr. Khan joined the Houston Methodist Research Institute as a Research Scientist and Assistant Research Member in January 2019, where he works in the research group of Chinnaswamy Jagannath, PhD. Dr. Khan currently is investigating host/pathogen interaction during tuberculosis infection, with special emphasis on studying the metabolic pathways of Mycobacterium tuberculosis and immune components of host cells during latent infection. For his ongoing research projects, Dr. Khan also continues to characterize and develop experimental animal models that can assist in the discovery of new tuberculosis vaccines and drug therapies.

Research interests

Dr. Khan’s primary research interest is in the development of novel ex vivo and preclinical animal models to further the discovery of novel anti-tuberculosis vaccines and drug therapies for the treatment of tuberculosis.  Current projects include the human MSC-based intracellular model to characterize MTB components involved in acquiring phenotypic drug resistance during dormant infection. Other research projects involve investigation of specific biomarkers and epigenetic signatures that exist on macrophages of TB-resistant and susceptible individuals. Additionally, Dr. Khan is interested in identifying the cellular niches that are involved in harboring latent tuberculosis infection, and the immune system inadequacies that can lead to the reactivation of the Mycobacterium tuberculosis pathogen.

Keywords

    Research Area Keywords

  • Infectious Disease & Pathology

    Free-text keywords

  • Mechanism of persistence of Mycobacterium tuberculosis, Role of innate cells in protection against M. tuberculosis, Cellular niches for M. tuberculosis in latent tuberculosis infection

External positions

Assistant Professor of Research in Pathology and Laboratory Medicine, Weill Cornell Medical College

Aug 1 2019 → …

Fingerprint

Mycobacterium tuberculosis
Concept: Mycobacterium tuberculosis
Weight: 100%
Domain: Medicine & Life Sciences
Mycobacterium bovis
Concept: Mycobacterium bovis
Weight: 80%
Domain: Medicine & Life Sciences
Autophagy
Concept: Autophagy
Weight: 73%
Domain: Medicine & Life Sciences
Tuberculosis
Concept: Tuberculosis
Weight: 65%
Domain: Medicine & Life Sciences
Macrophages
Concept: Macrophages
Weight: 48%
Domain: Medicine & Life Sciences
BCG Vaccine
Concept: BCG Vaccine
Weight: 40%
Domain: Medicine & Life Sciences
Mesenchymal Stromal Cells
Concept: Mesenchymal Stromal Cells
Weight: 34%
Domain: Medicine & Life Sciences
T-Lymphocytes
Concept: T-Lymphocytes
Weight: 30%
Domain: Medicine & Life Sciences
Tuberculosis Vaccines
Concept: Tuberculosis Vaccines
Weight: 25%
Domain: Medicine & Life Sciences
Mycobacterium smegmatis
Concept: Mycobacterium smegmatis
Weight: 24%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Arshad Khan is tagged with the concept

Research outputs

Commentary: Bettering BCG: a tough task for a TB vaccine?

Research output: Contribution to journalComment/debate

Interactions of Mycobacterium tuberculosis with Human Mesenchymal Stem Cells

Research output: Chapter in Book/Report/Conference proceedingChapter

Macrophage heterogeneity and plasticity in tuberculosis

Research output: Contribution to journalReview article

Pathogenesis and animal models of post-primary (Bronchogenic) tuberculosis, a review

Research output: Contribution to journalReview article

Projects

SigH based attenuated

Project: Federal Funding Agencies

Mesenchymal Stem Cell Niche for Tuberculosis

Project: Federal Funding Agencies

Journals

Microbial Pathogenesis

ISSNs: 0882-4010

Academic Press

Journal

2

Cellular Immunology

ISSNs: 0008-8749

Additional searchable ISSN (Electronic): 1090-2163

Academic Press

Journal

1

Frontiers in Immunology

Additional searchable ISSN (Electronic): 1664-3224

Frontiers Media S. A.

Journal

1

Vaccines

ISSNs: 2076-393X

Additional searchable ISSN (Electronic): 2076-393X

Multidisciplinary Digital Publishing Institute (MDPI), United States

Scopus rating (2018): CiteScore 5.43 SJR 2.136 SNIP 1.302

Journal

1

Pathogens

Additional searchable ISSN (Electronic): 2076-0817

MDPI AG

Scopus rating (2018): CiteScore 3.65 SJR 1.31 SNIP 1.3

Journal

1
has published Research OutputsResearch Output by Arshad Khan

Research Network

Visualization: Institutional Network

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Arshad Khan

Visualization: Co-author Network

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Arshad Khan

Shared Pub. Internal Organizations

Immunobiology & Transplant Science Center

Organizational unit: Programs

1
has Research OutputsResearch Output by Arshad Khan

Shared Pub. External Organizations

National Chemical Laboratory India

External organization: Unknown

6

University of Texas Health Science Center at Houston

External organization: Unknown

5

Baylor College of Medicine

External organization: Academic

4

Medical School

External organization: Unknown

3

Houston Methodist Research Institute

External organization: Unknown

3
has Research OutputsResearch Output by Arshad Khan

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Arshad Khan

Shared Pub. External co-authors

Dhiman Sarkar

External person

6

R. L. Hunter

External person

5

Christopher R. Singh

External person

4

Subramanian Dhandayuthapani

External person

3

Shamim Akhtar

External person

3
has co-authored Research OutputsResearch Output with Arshad Khan

ID: 43951839