• 371 Citations
  • 11 h-Index
20062020

Research output per year

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Personal profile

Personal profile

Arshad Khan received a PhD in Biotechnology from the University of Pune, Pune, India in September 2009. Following a post-doctoral fellowship in Pathology and Laboratory Medicine at the University of Texas Health Science Center’s McGovern School of Medicine, Dr. Khan was appointed as Assistant Professor of Pathology there in March 2016, with his research focusing on class I and Class II (MHC-I and MHC-II) antigen presentation of bacillus Calmette-Guerin (BCG) in order to improve the efficacy of the BCG vaccine against Mycobacterium tuberculosis

Dr. Khan joined the Houston Methodist Research Institute as a Research Scientist and Assistant Research Member in January 2019, where he works in the research group of Chinnaswamy Jagannath, PhD. Dr. Khan currently is investigating host/pathogen interaction during tuberculosis infection, with special emphasis on studying the metabolic pathways of Mycobacterium tuberculosis and immune components of host cells during latent infection. For his ongoing research projects, Dr. Khan also continues to characterize and develop experimental animal models that can assist in the discovery of new tuberculosis vaccines and drug therapies.

Research interests

Dr. Khan’s primary research interest is in the development of novel ex vivo and preclinical animal models to further the discovery of novel anti-tuberculosis vaccines and drug therapies for the treatment of tuberculosis.  Current projects include the human MSC-based intracellular model to characterize MTB components involved in acquiring phenotypic drug resistance during dormant infection. Other research projects involve investigation of specific biomarkers and epigenetic signatures that exist on macrophages of TB-resistant and susceptible individuals. Additionally, Dr. Khan is interested in identifying the cellular niches that are involved in harboring latent tuberculosis infection, and the immune system inadequacies that can lead to the reactivation of the Mycobacterium tuberculosis pathogen.

Education/Academic qualification

Pathology, Postdoctoral Fellowship, McGovern Medical School at UTHealth

Sep 1 2009Mar 1 2016

Award Date: Mar 1 2016

Biotechnology, PhD, National Chemical Laboratory India

Jan 1 2004Sep 1 2009

Award Date: Sep 1 2009

External positions

Assistant Professor of Research in Pathology and Laboratory Medicine, Weill Cornell Medical College

Aug 1 2019 → …

Research Area Keywords

  • Infectious Disease & Pathology

Free-text keywords

  • Mechanism of persistence of Mycobacterium tuberculosis
  • Role of innate cells in protection against M. tuberculosis
  • Cellular niches for M. tuberculosis in latent tuberculosis infection

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Projects

A Neonatal Monkey Model of Tuberculosis Vaccination

Jagannath, C. & Khan, A.

6/1/195/31/22

Project: Federal Funding Agencies

SigH based attenuated

Jagannath, C. & Khan, A.

5/1/194/30/23

Project: Federal Funding Agencies

Mesenchymal Stem Cell Niche for Tuberculosis

Jagannath, C. & Khan, A.

2/1/191/31/21

Project: Federal Funding Agencies

Research Output

Emerging prevention and treatment strategies to control COVID-19

Singh, V. K., Mishra, A., Singh, S., Kumar, P., Singh, M., Jagannath, C. & Khan, A., Jun 2020, In : Pathogens. 9, 6, p. 1-16 16 p., 501.

Research output: Contribution to journalReview article

  • GM-CSF Dependent Differential Control of Mycobacterium tuberculosis Infection in Human and Mouse Macrophages: Is Macrophage Source of GM-CSF Critical to Tuberculosis Immunity?

    Mishra, A., Singh, V. K., Actor, J. K., Hunter, R. L., Jagannath, C., Subbian, S. & Khan, A., Jul 23 2020, In : Frontiers in immunology. 11, 1599.

    Research output: Contribution to journalArticle

  • Human mesenchymal stem cell based intracellular dormancy model of Mycobacterium tuberculosis

    Singh, V. K., Mishra, A., Bark, S., Mani, A., Subbian, S., Hunter, R. L., Jagannath, C. & Khan, A., Jun 17 2020, In : Microbes and Infection.

    Research output: Contribution to journalArticle

  • An autophagy-inducing and TLR-2 activating BCG vaccine induces a robust protection against tuberculosis in mice

    Khan, A., Bakhru, P., Saikolappan, S., Das, K., Soudani, E., Singh, C. R., Estrella, J. L., Zhang, D., Pasare, C., Ma, Y., Sun, J., Wang, J., Hunter, R. L., Tony Eissa, N., Dhandayuthapani, S. & Jagannath, C., Dec 1 2019, In : npj Vaccines. 4, 1, p. 34 34.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    Commentary: Bettering BCG: a tough task for a TB vaccine?

    Srivastava, B. S., Singh, V. K., Kashyap, V. K., Srivastava, R., Khan, A. & Jagannath, C., Sep 12 2019, In : Frontiers in immunology. 10, 2195.

    Research output: Contribution to journalComment/debate