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Antonio Gotto, MD, DPhil

1958 …2026

Research activity per year

Personal profile

Personal profile

Dr. Antonio M. Gotto is the Stephen and Suzanne Weiss Dean of Weill Cornell Medical College in New York, New York, where he is also Professor of Medicine. In addition, Dr. Gotto is Provost for Medical Affairs of Cornell University. He joined Houston Methodist Research Institute in 2011. Previously, at Baylor College of Medicine in Houston, Texas, he was the Bob and Vivian Smith Professor and Chairman of the Department of Medicine, Scientific Director of the DeBakey Heart Center, and the JS Abercrombie Chair for Atherosclerosis and Lipoprotein Research. He also served as Chief of the Internal Medicine Service at The Methodist Hospital in Houston. Dr. Gotto's postgraduate work included doctoral studies at Oxford University in England as a Rhodes Scholar, and residency training at the Massachusetts General Hospital in Boston, Massachusetts.

As a lifelong supporter of educational efforts aimed at cardiovascular risk reduction, Dr. Gotto has been National President of the American Heart Association and President of the International Atherosclerosis Society. He is a member of the Institute of Medicine and the American Academy of Arts and Sciences and a recipient of many honors, including the Gold Heart Award from the American Heart Association, the 2000 Distinguished Alumnus award from Vanderbilt University and the Vanderbilt University School of Medicine, honorary doctoral degrees from the University of Bologna and Abilene Christian University, honorary professorships from the University of Buenos Aires and Francisco Marroquin University (Guatemala), and the Order of the Lion from the Republic of Finland. Dr. Gotto was the 2004 recipient of the International Okamoto Award from the Japan Vascular Disease Research Foundation. In 2004 Dr. Gotto was also named Honorary Member of the Society for Progress in Internal Medicine (Ludwig Heilmeyer Society) in Germany. In 2010, he received the Maurice R. Greenberg Distinguished Service Award, the highest honor bestowed by New York-Presbyterian/Weill Cornell on members of the medical staff.

Dr. Gotto speaks nationally and internationally on cardiovascular disease and has contributed more than 500 scholarly articles and books to the medical literature. In addition, he is coauthor of a series of books that explain the origins and treatment of cardiovascular disease to the general public.

Research interests

In the field of atherosclerosis, his basic science research interests include clinical disorders of lipid transport and the structure, metabolism, and function of lipoproteins and apolipoproteins. He and his associates were the first to achieve complete synthesis of a plasma apolipoprotein (apo C-I); they also determined the complete cDNA and amino acid sequence of apo B-100, one of the largest proteins ever sequenced and a key protein in atherosclerosis. In addition, Dr. Gotto has played a leading role in several landmark clinical trials demonstrating that cholesterol-lowering drug treatment can reduce the risk of heart disease.

Education/Academic qualification

MD, Vanderbilt University

Jul 1 1961Jun 30 1965

Award Date: Jun 30 1965

Biochemistry, D Phil, University of Oxford

Research Area Keywords

  • Heart & Vascular
  • Clinical Care
  • Clinical Translation & Trials

Free-text keywords

  • Lipoproteins and apolipoproteins
  • Atherosclerosis
  • Lipid metabolism
  • Statins

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  • Assessment of adverse effects attributed to statin therapy in product labels: a meta-analysis of double-blind randomised controlled trials

    Reith, C., Blackwell, L., Emberson, J. R., Preiss, D., Spata, E., Davies, K., Halls, H., Harper, C., Holland, L., Wilson, K., Humphrey, R., Roddick, A. J., Cannon, C. P., Davis, B. R., Durrington, P. N., Goto, S., Hitman, G. A., Hovingh, G. K., Koenig, W. & Krane, V. & 116 others, Landray, M. J., Mihaylova, B., Newman, C., Probstfield, J. L., Sabatine, M. S., Sattar, N., Schwartz, G. G., Tonkin, A. M., White, H. D., Armitage, J., Keech, A., Simes, J., Collins, R., Baigent, C., Barnes, E., Fulcher, J., Herrington, W. G., Kirby, A., O'Connell, R., Amarenco, P., Arashi, H., Barter, P., Betteridge, D. J., Blazing, M., Blauw, G. J., Bonaca, M., Bosch, J., Bowman, L., Braunwald, E., Bulbulia, R., Byington, R., Clarke, R., Clearfield, M., Cobbe, S., Colhoun, H. M., Dahlöf, B., de Lemos, J., Downs, J. R., Fellström, B., Fine, L., Flather, M., Ford, I., Franzosi, M. G., Fuller, J., Furberg, C., Glynn, R., Goldbourt, U., Gordon, D., Gotto,, A., Grimm, R., Gupta, A., Hawkins, C. M., Haynes, R., Holdaas, H., Hopewell, J., Jardine, A., Jukema, J. W., Kastelein, J. J. P., Kean, S., Kearney, P., Kitas, G., Kjekshus, J., Knatterud, G., Knopp, R. H., Kjekshus, J., Koren, M., LaRosa, J., Latini, R., Lonn, E., Lucci, D., MacFadyen, J., Macfarlane, P., MacMahon, S., Maggioni, A., Marchioli, R., Marschner, I., Moyé, L., Murray, H., Murphy, S., Neil, A., Nicolis, E. B., Packard, C., Parish, S., Pedersen, T. R., Peto, R., Pfeffer, M., Poulter, N., Pressel, S., Rahman, M., Ridker, P. M., Robertson, M., Sacks, F., Schmieder, R., Serruys, P. W., Sever, P., Shaw, J., Shepherd, J., Simpson, L., Sleight, P., Smeeth, L., Tavazzi, L., Tobert, J., Tognoni, G., Trompet, S., Varigos, J., Wanner, C., Wedel, H., Weis, S., Welch, K. M., Wikstrand, J., Wilhelmsen, L., Wiviott, S., Yamaguchi, J., Young, R., Yusuf, S. & Zannad, F., Feb 14 2026, In: The Lancet. 407, 10529, p. 689-703 15 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Atherosclerotic features in patients with heart failure

    Ceasovschih, A., Banjanin, N., Bednarek, A., Beqiraj, A., Cherska, M., Ejubović, M., Jakubova, M., Markos, S., Ristovski, V., Scicali, R., Banach, M., Sorodoc, V. & Gotto, A. M., Apr 2025, In: Archives of Medical Science. 21, 4, p. 1107-1129 23 p.

    Research output: Contribution to journalEditorialpeer-review

    Open Access
  • HDL-free cholesterol influx into macrophages and transfer to LDL correlate with HDL-free cholesterol content

    Yelamanchili, D., Gillard, B. K., Gotto, A. M., Achirica, M. C., Nasir, K., Remaley, A. T., Rosales, C. & Pownall, H. J., Jan 2025, In: Journal of lipid research. 66, 1, p. 100707 100707.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • LDL atherogenicity determined by size, density, oxidation, apolipoprotein(a), and electronegativity: an updated review

    Akyol, O., Chiang, H. H., Burns, A. R., Yang, C. Y., Woodside, D. G., Sawamura, T., Sánchez-Quesada, J. L., Gotto, A. M. & Chen, C. H., Oct 13 2025, In: Frontiers in cardiovascular medicine. 12, p. 1649759 1649759.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
  • Akira Endo (1933–2024), in memoriam

    Brown, W. V., Schaefer, E. J. & Gotto, A. M., Nov 2024, In: Journal of Clinical Lipidology. 18, 6, p. e879-e881

    Research output: Contribution to journalArticlepeer-review