Projects per year
Personal profile
Personal profile
Chih-Chi Andrew Hu, PhD, earned his Bachelor’s degree from China Medical University and Master’s degree from National Sun Yat-Sen University in Taiwan. During his military service as a second lieutenant, he taught histology and performed research at the National Defense Medical Center. Dr. Hu pursued his doctoral training at the New York University School of Medicine (2001-2006) to study membrane protein assembly on the surface of the urinary bladder. Dr. Hu pursued his postdoctoral training with Dr. Hidde L. Ploegh, at the Whitehead Institute/Massachusetts Institute of Technology (2006-2010) to study the functions of the endoplasmic reticulum in normal B cells. He became an Assistant Professor at the Moffitt Cancer Center/University of South Florida (2010-2014) and was later recruited to the Wistar Institute/University of Pennsylvania as an Associate Professor (2014-2019). He was promoted to Full Professor at the same institute in 2020 and recruited to the Houston Methodist Research Institute in December 2020.
Research interests
My laboratory investigates the biology of the endoplasmic reticulum (ER) in normal and malignant B cells. The work from my laboratory establishes that inhibiting the IRE-1/XBP-1s pathway of the ER stress response and activating IRE-1’s interacting protein, STING, are effective therapeutic strategies for B cell cancer and graft-versus-host disease. We also develop novel small molecules to target these pathways. We continue to identify and characterize ER-resident proteins that can be targeted for therapy of human diseases.
External positions
Professor of Cancer Biology in Medicine, Weill Cornell Medical College
Mar 1 2022 → …
Professor, Texas A&M University, College of Medicine, Bryan, TX, USA.
May 1 2021 → …
Research Area Keywords
- Cancer
Free-text keywords
- Endoplasmic reticulum
- stress response
- B lymphocyte
- Leukemia
- Lymphoma
- Myeloma
- Immunology
- Drug development
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Mechanisms of STING in malignant progression and therapy of CLL.
2/1/23 → 1/31/28
Project: Federal Funding Agencies
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Targeting IRE-1a/XBP-1 Axis for Control of Chronic GVHD and Leukemia Relapse
5/10/22 → 6/30/23
Project: Federal Funding Agencies
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XBP1 Inhibition and STING activation for the treatment of cancer
4/8/22 → 3/31/27
Project: Federal Funding Agencies
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ER stress response and chronic lymphocytic leukemia
Hu, C. A., Pingali, S. R. & Tang, C. A.
9/3/21 → …
Project: Clinical Trial
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African trypanosome parasites: a new tool to unveil potential immunological strategies totarget CLL
5/3/21 → 4/30/24
Project: Federal Funding Agencies
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Long term outcomes in older patients with primary central nervous system lymphoma: an analysis of the Texas Cancer Registry
Burns, E. A., Sanchez, C. G., Mathur, S., Guerrero, C., Muhsen, I. N., Sarfraz, H., Hu, C. C. A., Tang, C. H. A., Shah, S. S., Tremont, I. W., Teh, B., Ganguly, S. & Pingali, S. R. K., May 2023, In: Annals of Hematology. 102, 5, p. 1111-1120 10 p.Research output: Contribution to journal › Article › peer-review
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Correction for Bagashev et al., "CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum"
Bagashev, A., Sotillo, E., Tang, C-H. A., Black, K. L., Perazzelli, J., Seeholzer, S. H., Argon, Y., Barrett, D. M., Grupp, S. A., Hu, C-C. A. & Thomas-Tikhonenko, A., Sep 15 2022, In: Molecular and Cellular Biology. 42, 9, p. e0032822Research output: Contribution to journal › Article › peer-review
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Erratum: Correction for Bagashev et al., "CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum" (Molecular and cellular biology (2018) 38 21)
Bagashev, A., Sotillo, E., Tang, C. H. A., Black, K. L., Perazzelli, J., Seeholzer, S. H., Argon, Y., Barrett, D. M., Grupp, S. A., Hu, C. C. A. & Thomas-Tikhonenko, A., Sep 15 2022, In: Molecular and Cellular Biology. 42, 9, p. e0032822Research output: Contribution to journal › Comment/debate › peer-review
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IRE-1-Targeting Caged Prodrug with Endoplasmic Reticulum Stress-Inducing and XBP-1S-Inhibiting Activities for Cancer Therapy
Shao, A., Xu, Q., Kang, C. W., Cain, C. F., Lee, A. C., Tang, C. H. A., Del Valle, J. R. & Hu, C. C. A., Apr 4 2022, In: Molecular pharmaceutics. 19, 4, p. 1059-1067 9 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Loss of AID exacerbates the malignant progression of CLL
Lee, A. C., Pingali, S. R., Pinilla-Ibarz, J. A., Atchison, M. L., Koumenis, C., Argon, Y., Thomas-Tikhonenko, A., De Trez, C., Hu, C. C. A. & Tang, C. H. A., Oct 2022, In: Leukemia. 36, 10, p. 2430-2442 13 p.Research output: Contribution to journal › Article › peer-review
Open Access