Personal profile

Dr. Andrew Dannenberg is the Henry R. Erle, MD-Roberts Family Professor of Medicine at Weill Cornell Medical College.  He received his medical degree from Washington University in St. Louis and served as a medical resident and gastroenterology fellow at The New York Hospital-Cornell Medical Center. His research focuses on the mechanisms underlying the inflammation-cancer connection in multiple organs. Dr. Dannenberg has authored more than 200 scientific articles, and edited several books and journals. In 2011, he was awarded the American Association for Cancer Research-Prevent Cancer Foundation award for excellence in cancer prevention research. He is a member of the Association of American Physicians, the American Society for Clinical Investigation, and the American Association for Cancer Research. He previously chaired the Program Committee of the AACR "Frontiers in Cancer Prevention Research" meeting and serves on the editorial boards of several journals including Cancer Prevention Research and the Journal of Clinical Oncology. 

Research interests

Dr. Dannenberg’s research is focused on the connection between chronic inflammation and cancer with an emphasis on prostaglandin (PG) biology. The long-term goal of this research is to develop evidence-based strategies to decrease inflammation and reduce the risk of developing cancer.

Human cancers, premalignant lesions and chronic inflammatory states (e.g. ulcerative colitis), are identified in which the expression of enzymes involved in PG biosynthesis (cyclooxygenase-2, COX-2), catabolism (15-hydroxyprostaglandin dehydrogenase) or transport (PGT) is deregulated. The signal transduction pathways that control the expression of these genes in normal and diseased tissues are then explored. In this way, the mechanisms by which PGs impact wound healing or stimulate the formation and progression of tumors are being defined.

As second major focus of the research program is hormone receptor-positive breast cancer, and a key signaling pathway by which PGE2 induces cytochrome P450 aromatase, the enzyme that catalyzes the synthesis of estrogens from androgens. Pharmacological and genetic studies are used to assess the impact of targeting specific molecules involved in PG synthesis on tumor formation and growth. The contribution of body mass and diet to changes in PG levels, inflammation and the expression of genes implicated in carcinogenesis is also being explored. Given the link between chronic colitis and colon cancer, a major goal is to identify PG-responsive genes that play key roles in colorectal mucosal homeostasis, and biomarkers that may reflect inflammation and cancer prognosis.

Keywords

    Free-text keywords

  • Cancer, Breast, Prostaglandin, Inflammation

External positions

Weill Cornell Medical College

Fingerprint

Cyclooxygenase 2
Concept: Cyclooxygenase 2
Weight: 100%
Domain: Medicine & Life Sciences
Neoplasms
Concept: Neoplasms
Weight: 30%
Domain: Medicine & Life Sciences
Celecoxib
Concept: Celecoxib
Weight: 29%
Domain: Medicine & Life Sciences
Dinoprostone
Concept: Dinoprostone
Weight: 28%
Domain: Medicine & Life Sciences
Breast Neoplasms
Concept: Breast Neoplasms
Weight: 28%
Domain: Medicine & Life Sciences
Obesity
Concept: Obesity
Weight: 28%
Domain: Medicine & Life Sciences
Inflammation
Concept: Inflammation
Weight: 25%
Domain: Medicine & Life Sciences
Breast
Concept: Breast
Weight: 25%
Domain: Medicine & Life Sciences
Aromatase
Concept: Aromatase
Weight: 22%
Domain: Medicine & Life Sciences
Prostaglandin-Endoperoxide Synthases
Concept: Prostaglandin-Endoperoxide Synthases
Weight: 19%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Andrew Dannenberg is tagged with the concept

Journals

Cancer Prevention Research

ISSNs: 1940-6207

Additional searchable ISSN (Electronic): 1940-6215

American Association for Cancer Research Inc.

Journal

39

The Journal of biological chemistry

ISSNs: 0021-9258

American Society for Biochemistry and Molecular Biology Inc.

Journal

26

Cancer Research

ISSNs: 0008-5472

American Association for Cancer Research Inc.

Journal

22

Clinical Cancer Research

ISSNs: 1078-0432

American Association for Cancer Research Inc.

Journal

20

Carcinogenesis

ISSNs: 0143-3334

Oxford University Press

Journal

10
has published Research OutputsResearch Output by Andrew Dannenberg

Research Network

Visualization: Institutional Network

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Andrew Dannenberg

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Andrew Dannenberg

Shared Pub. Internal Organizations

Institute for Academic Medicine

Organizational unit: Institutes

1

Department of Medicine

Organizational unit: Departments

1

Houston Methodist Hospital

Organizational unit: Schools & Hospitals

1

Lynda K. and David M. Underwood Center for Digestive Disorders

Organizational unit: Centers of Excellence

1

Weill Cornell Medical College

Organizational unit: Schools & Hospitals

1
has Research OutputsResearch Output by Andrew Dannenberg

Shared Pub. External Organizations

Weill Medical College of Cornell University

External organization: Unknown

157

Memorial Sloan-Kettering Cancer Center

External organization: Unknown

90

Strang Cancer Prevention Center

External organization: Unknown

28

University of Texas M. D. Anderson Cancer Center

External organization: Unknown

24

National Cancer Institute

External organization: Unknown

22
has Research OutputsResearch Output by Andrew Dannenberg

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Andrew Dannenberg

Shared Pub. External co-authors

Kotha Subbaramaiah

External person

117

Clifford A. Hudis

External person

36

Baoheng Du

External person

24

Xi Kathy Zhou

External person

22

Jay O. Boyle

External person

20
has co-authored Research OutputsResearch Output with Andrew Dannenberg

ID: 2286663