Research outputs

  1. 2019
  2. 2-Hydroxypropyl-β-cyclodextrin-enhanced pharmacokinetics of cabotegravir from a nanofluidic implant for HIV pre-exposure prophylaxis

    Pons-Faudoa, F. P., Sizovs, A., Di Trani, N., Paez-Mayorga, J., Bruno, G., Rhudy, J., Manohar, M., Gwenden, K., Martini, C., Chua, C. Y. X., Varchi, G., Marzinke, M. A. & Grattoni, A., Jul 28 2019, In : Journal of Controlled Release. 306, p. 89-96 8 p.

    Research output: Contribution to journalArticle

  3. Advanced implantable drug delivery technologies: transforming the clinical landscape of therapeutics for chronic diseases

    Pons-Faudoa, F. P., Ballerini, A., Sakamoto, J. & Grattoni, A., Jun 1 2019, In : Biomedical Microdevices. 21, 2, 47.

    Research output: Contribution to journalArticle

  4. Nanofluidic microsystem for sustained intraocular delivery of therapeutics

    Di Trani, N., Jain, P., Chua, C. Y. X., Ho, J. S., Bruno, G., Susnjar, A., Pons-Faudoa, F. P., Sizovs, A., Lyle Hood, R., Smith, Z. W., Ballerini, A., Filgueira, C. S. & Grattoni, A., Feb 1 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 16, p. 1-9 9 p.

    Research output: Contribution to journalArticle

  5. Remotely controlled nanofluidic implantable platform for tunable drug delivery

    Di Trani, N., Silvestri, A., Bruno, G., Geninatti, T., Chua, C. Y. X., Gilbert, A., Rizzo, G., Filgueira, C. S., Demarchi, D. & Grattoni, A., Jan 1 2019, In : Lab on a Chip. 19, 13, p. 2192-2204 13 p.

    Research output: Contribution to journalArticle

  6. Technologies for intrapericardial delivery of therapeutics and cells

    Filgueira, C. S., Igo, S. R., Wang, D. K., Hirsch, M., Schulz, D. G., Bruckner, B. A. & Grattoni, A., Jan 1 2019, In : Advanced Drug Delivery Reviews.

    Research output: Contribution to journalArticle

  7. 2018
  8. METHOD AND APPARATUS FOR THE FAIL-SAFE TERMINATION OF IN VIVO DRUG DELIVERY FROM AN IMPLANTABLE DRUG DELIVERY SYSTEM

    Farina, M., Hood, R. L. & Grattoni, A., Oct 4 2018, IPC No. A61M 5/ 142 A I, Patent No. US2018280617, Priority date Oct 19 2016, Priority No. US201615769401

    Research output: Patent

  9. Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre-exposure prophylaxis

    Chua, C. Y. X., Jain, P., Ballerini, A., Bruno, G., Hood, R. L., Gupte, M., Gao, S., Di Trani, N., Susnjar, A., Shelton, K., Bushman, L. R., Folci, M., Filgueira, C. S., Marzinke, M. A., Anderson, P. L., Hu, M., Nehete, P., Arduino, R. C., Sastry, J. K. & Grattoni, A., Sep 28 2018, In : Journal of Controlled Release. 286, p. 315-325 11 p.

    Research output: Contribution to journalArticle

  10. Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy in triple negative breast cancer

    Chua, C. Y. X., Jain, P., Susnjar, A., Rhudy, J., Folci, M., Ballerini, A., Gilbert, A., Singh, S., Bruno, G., Filgueira, C. S., Yee, C., Butler, E. B. & Grattoni, A., Sep 10 2018, In : Journal of Controlled Release. 285, p. 23-34 12 p.

    Research output: Contribution to journalArticle

  11. Transcutaneously refillable, 3D-printed biopolymeric encapsulation system for the transplantation of endocrine cells

    Farina, M., Chua, C. Y. X., Ballerini, A., Thekkedath, U., Alexander, J. F., Rhudy, J. R., Torchio, G., Fraga, D., Pathak, R. R., Villanueva, M., Shin, C. S., Niles, J. A., Sesana, R., Demarchi, D., Sikora, A. G., Acharya, G. S., Gaber, A. O., Nichols, J. & Grattoni, A., Sep 1 2018, In : Biomaterials. 177, p. 125-138 14 p.

    Research output: Contribution to journalArticle

  12. Adipocytes impair efficacy of antiretroviral therapy

    Couturier, J., Winchester, L. C., Suliburk, J. W., Wilkerson, G. K., Podany, A. T., Agarwal, N., Xuan Chua, C. Y., Nehete, P. N., Nehete, B. P., Grattoni, A., Sastry, K. J., Fletcher, C. V., Lake, J. E., Balasubramanyam, A. & Lewis, D. E., Jun 1 2018, In : Antiviral Research. 154, p. 140-148 9 p.

    Research output: Contribution to journalArticle

  13. Efficacy of sustained delivery of GC-1 from a Nanofluidic system in a spontaneously obese non-human primate: a case study

    Filgueira, C. S., Bruno, G., Smith, Z. W., Chua, C. Y. X., Ballerini, A., Folci, M., Gilbert, A. L., Jain, P., Sastry, J. K., Nehete, P. N., Shelton, K. A., Hill, L. R., Ali, A., Youker, K. A. & Grattoni, A., Jun 1 2018, In : Biomedical Microdevices. 20, 2, 49.

    Research output: Contribution to journalArticle

  14. IMPLANTABLE NANOCHANNEL DELIVERY DEVICES

    Grattoni, A., Butler, E. B. & Palapattu, G., May 10 2018, IPC No. A61M 37/ 00 A I, Patent No. US2018125780, Priority date May 16 2016, Priority No. US201615574185

    Research output: Patent

  15. Unexpected behaviors in molecular transport through size-controlled nanochannels down to the ultra-nanoscale

    Bruno, G., Di Trani, N., Hood, R. L., Zabre, E., Filgueira, C. S., Canavese, G., Jain, P., Smith, Z., Demarchi, D., Hosali, S., Pimpinelli, A., Ferrari, M. & Grattoni, A., Apr 27 2018, In : Nature communications. 9, 1, 1682.

    Research output: Contribution to journalArticle

  16. Mechanical characterization and numerical simulation of a subcutaneous implantable 3D printed cell encapsulation system

    Adamo, F., Farina, M., Thekkedath, U. R., Grattoni, A. & Sesana, R., Mar 21 2018, In : Journal of the Mechanical Behavior of Biomedical Materials. 82, p. 133-144 12 p.

    Research output: Contribution to journalArticle

  17. Nanofluidics for cell and drug delivery

    Di Trani, N., Grattoni, A. & Ferrari, M., Jan 23 2018, 2017 IEEE International Electron Devices Meeting, IEDM 2017. Institute of Electrical and Electronics Engineers Inc., Vol. Part F134366. p. 40.6.1-40.6.4

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  18. Gas Flow at the Ultra-nanoscale: Universal Predictive Model and Validation in Nanochannels of Ångstrom-Level Resolution

    Scorrano, G., Bruno, G., Di Trani, N., Ferrari, M., Pimpinelli, A. & Grattoni, A., Jan 1 2018, (Accepted/In press) In : ACS Applied Materials and Interfaces.

    Research output: Contribution to journalArticle

  19. Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyond

    Farina, M., Alexander, J. F., Thekkedath, U., Ferrari, M. & Grattoni, A., 2018, (Accepted/In press) In : Advanced Drug Delivery Reviews.

    Research output: Contribution to journalArticle

  20. 2017
  21. Physicochemical properties of inclusion complexes of highly soluble β-cyclodextrins with highly hydrophobic testosterone propionate

    Celia, C., Scala, A., Stancanelli, R., Surdo, E., Paolino, D., Grattoni, A., Micale, N., Crupi, V., Majolino, D., Fresta, M., Tommasini, S., Venuti, V. & Ventura, C. A., Dec 20 2017, In : International Journal of Pharmaceutics. 534, 1-2, p. 316-324 9 p.

    Research output: Contribution to journalArticle

  22. A pharmacokinetic study of GC-1 delivery using a nanochannel membrane device

    Filgueira, C. S., Ballerini, A., Nicolov, E., Chua, C. Y. X., Jain, P., Smith, Z. W., Gilbert, A. L., Scaglione, F. & Grattoni, A., Jul 1 2017, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 5, p. 1739-1744 6 p.

    Research output: Contribution to journalArticle

  23. Remote magnetic switch off microgate for nanofluidic drug delivery implants

    Farina, M., Ballerini, A., Torchio, G., Rizzo, G., Demarchi, D., Thekkedath, U. & Grattoni, A., Jun 1 2017, In : Biomedical Microdevices. 19, 2, 42.

    Research output: Contribution to journalArticle

  24. METHOD AND APPARATUS FOR THE FAIL-SAFE TERMINATION OF IN VIVO DRUG DELIVERY FROM AN IMPLANTABLE DRUG DELIVERY SYSTEM

    Farina, M., HOOD, Robert, L. & Grattoni, A., Apr 27 2017, IPC No. F16K 17/ 38 A I, Patent No. WO2017070165, Priority date Oct 19 2015, Priority No. US201562243265P

    Research output: Patent

  25. Pioneering medical advances through nanofluidic implantable technologies

    Hood, R. L., Hood, G. D., Ferrari, M. & Grattoni, A., Mar 10 2017, In : Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology.

    Research output: Contribution to journalArticle

  26. 3D Printed Vascularized Device for Subcutaneous Transplantation of Human Islets

    Farina, M., Ballerini, A., Fraga, D. W., Nicolov, E., Hogan, M., Demarchi, D., Scaglione, F., Sabek, O. M., Horner, P., Thekkedath, U., Gaber, O. A. & Grattoni, A., 2017, (Accepted/In press) In : Biotechnology Journal.

    Research output: Contribution to journalArticle

  27. 2016
  28. The active modulation of drug release by an ionic field effect transistor for an ultra-low power implantable nanofluidic system

    Bruno, G., Canavese, G., Liu, X., Filgueira, C. S., Sacco, A., Demarchi, D., Ferrari, M. & Grattoni, A., Nov 28 2016, In : Nanoscale. 8, 44, p. 18718-18725 8 p.

    Research output: Contribution to journalArticle

  29. IMPLANTABLE NANOCHANNEL DELIVERY DEVICES

    Grattoni, A., Butler, E. B. & Palapattu, G., Nov 24 2016, IPC No. A61M 37/ 00 A I, Patent No. WO2016187100, Priority date May 15 2015, Priority No. US201562161986P

    Research output: Patent

  30. Nanochannel implants for minimally-invasive insertion and intratumoral delivery

    Hood, R. L., Bruno, G., Jain, P., Anderson, J., Wolfe, T., Quini, C., Schmulen, J., Li, X. C., Butler, E. B., Krishnan, S. & Grattoni, A., Oct 1 2016, In : Journal of Biomedical Nanotechnology. 12, 10, p. 1907-1915 9 p.

    Research output: Contribution to journalArticle

  31. Sustained zero-order delivery of GC-1 from a nanochannel membrane device alleviates metabolic syndrome

    Filgueira, C. S., Nicolov, E., Hood, R. L., Ballerini, A., Garcia-Huidobro, J., Lin, J. Z., Fraga, D., Webb, P., Sabek, O., Gaber, A. O., Phillips, K. J. & Grattoni, A., Aug 23 2016, In : International Journal of Obesity.

    Research output: Contribution to journalArticle

  32. The Emerging Role of Nanotechnology in Cell and Organ Transplantation

    Tasciotti, E., Cabrera, F. J., Evangelopoulos, M., Martinez, J. O., Thekkedath, U. R., Kloc Stepkowska, M., Ghobrial, R. M., Li, X. C., Grattoni, A. & Ferrari, M., Jun 2 2016, (Accepted/In press) In : Transplantation.

    Research output: Contribution to journalArticle

  33. Nanochanneled device with electrodes and related methods

    Fine, D., Grattoni, A., Ferrari, M., Liu, X., Goodall, R. & Hosali, S., Apr 27 2016, IPC No. A61K 9/ 48 A I, Patent No. CN105530988, Priority date Aug 1 2014, Priority No. WO2014US49404

    Research output: Patent

  34. Three-dimensional printed polymeric system to encapsulate human mesenchymal stem cells differentiated into islet-like insulin-producing aggregates for diabetes treatment

    Sabek, O., Farina, M., Fraga, D. W., Afshar, S., Ballerini, A., Filgueira, C. S., Thekkedath, U. R., Grattoni, A. & Gaber, A. O., Apr 22 2016, In : Journal of Tissue Engineering. 7, 13 p.

    Research output: Contribution to journalArticle

  35. NANOCHANNELED DEVICE AND RELATED METHODS

    Ferrari, M. M., Liu, X., Grattoni, A. A., Hosali, S. S., Goodall, R. R., Medema, R. R., Hudson, L. L. & Fine, D. D., Apr 8 2016, IPC No. B82Y C I, Patent No. HK1209626, Priority date Apr 13 2009, Priority No. US20090168844P

    Research output: Patent

  36. 2015
  37. NANOCHANNELED DEVICE AND RELATED METHODS

    Ferrari, M. M., Liu, X., Grattoni, A. A., Hosali, S. S., Goodall, R. R., Medema, R. R., Hudson, L. L. & Fine, D. D., Oct 30 2015, IPC No. A61M C I, Patent No. HK1164179, Priority date Nov 13 2009, Priority No. WO2009US64376

    Research output: Patent

  38. NANOCHANNELED DEVICE AND RELATED METHODS

    Ferrari, M., Liu, X., Grattoni, A., Goodall, R. & Hudson, L., Sep 3 2015, IPC No. A61M 5/ 00 A I, Patent No. US2015246174, Priority date Mar 16 2015, Priority No. US201514658561

    Research output: Patent

  39. The Nanochannel Delivery System for Constant Testosterone Replacement Therapy

    Ferrati, S., Nicolov, E., Zabre, E., Geninatti, T., Shirkey, B. A., Hudson, L., Hosali, S., Crawley, M., Khera, M., Palapattu, G. & Grattoni, A., Jun 1 2015, In : Journal of Sexual Medicine. 12, 6, p. 1375-1380 6 p.

    Research output: Contribution to journalArticle

  40. Leveraging electrokinetics for the active control of dendritic fullerene-1 release across a nanochannel membrane

    Bruno, G., Geninatti, T., Hood, R. L., Fine, D., Scorrano, G., Schmulen, J., Hosali, S., Ferrari, M. & Grattoni, A., Mar 28 2015, In : Nanoscale. 7, 12, p. 5240-5248 9 p.

    Research output: Contribution to journalArticle

  41. Delivering Enhanced Testosterone Replacement Therapy through Nanochannels

    Ferrati, S., Nicolov, E., Bansal, S., Zabre, E., Geninatti, T., Ziemys, A., Hudson, L., Ferrari, M., Goodall, R., Khera, M., Palapattu, G. & Grattoni, A., Feb 1 2015, In : Advanced Healthcare Materials. 4, 3, p. 446-451 6 p.

    Research output: Contribution to journalArticle

  42. Impedance characterization, degradation, and in vitro biocompatibility for platinum electrodes on BioMEMS

    Geninatti, T., Bruno, G., Barile, B., Hood, R. L., Farina, M., Schmulen, J., Canavese, G. & Grattoni, A., Feb 1 2015, In : Biomedical Microdevices. 17, 1, p. 24 1 p.

    Research output: Contribution to journalArticle

  43. Docetaxel/2-hydroxypropyl β -cyclodextrin inclusion complex increases docetaxel solubility and release from a nanochannel drug delivery system

    Ferrati, S., Nicolov, E., Bansal, S., Hosali, S., Landis, M. & Grattoni, A., 2015, In : Current Drug Targets. 16, 14, p. 1645-1649 5 p.

    Research output: Contribution to journalArticle

  44. Sustained administration of hormones exploiting nanoconfined diffusion through nanochannel membranes

    Geninatti, T., Lyle Hood, R., Bruno, G., Jain, P., Nicolov, E., Ziemys, A. & Grattoni, A., 2015, In : Materials. 8, 8, p. 5276-5288 13 p.

    Research output: Contribution to journalArticle

  45. 2014
  46. Functional validation of an implantable medical dosing device by MRI at 3T

    Anderson, J. R., Ferrati, S., Karmonik, C. & Grattoni, A., Nov 2 2014, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., p. 2346-2347 2 p. 6944091

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  47. MP43-20 NANOTECHNOLOGY-BASED IMPLANT FOR LONG TERM TESTOSTERONE REPLACEMENT

    Nicolov, E., Ferrati, S., Goodall, R., Hudson, L., Hosali, S., Crowley, M., Palapattu, G., Khera, M. & Grattoni, A., Apr 1 2014, In : The Journal of urology. 191, 4, p. e485-e486

    Research output: Contribution to journalArticle

  48. Robotic UV-Vis apparatus for long-term characterization of drug release from nanochannels

    Geninatti, T., Small, E. & Grattoni, A., Feb 1 2014, In : Measurement Science and Technology. 25, 2, 027003.

    Research output: Contribution to journalArticle

  49. Sustained zero-order release of intact ultra-stable drug-loaded liposomes from an implantable nanochannel delivery system

    Celia, C., Ferrati, S., Bansal, S., van de Ven, A. L., Ruozi, B., Zabre, E., Hosali, S., Paolino, D., Sarpietro, M. G., Fine, D., Fresta, M., Ferrari, M. & Grattoni, A., Feb 1 2014, In : Advanced Healthcare Materials. 3, 2, p. 230-238 9 p.

    Research output: Contribution to journalArticle

  50. 2013
  51. Leveraging nanochannels for universal, zero-order drug delivery in vivo

    Ferrati, S., Fine, D., You, J., De Rosa, E., Hudson, L., Zabre, E., Hosali, S., Zhang, L., Hickman, C., Sunder Bansal, S., Cordero-Reyes, A. M., Geninatti, T., Sih, J., Goodall, R., Palapattu, G., Kloc, M., Ghobrial, R. M., Ferrari, M. & Grattoni, A., Nov 13 2013, In : Journal of Controlled Release. 172, 3, p. 1011-1019 9 p.

    Research output: Contribution to journalArticle

  52. Characterization of a nanogland for the autotransplantation of human pancreatic islets

    Sabek, O., Ferrati, S., Fraga, D. W., Sih, J., Zabre, E. V., Fine, D. H., Ferrari, M., Gaber, A. O. & Grattoni, A., Sep 21 2013, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 13, 18, p. 3675-3688 14 p.

    Research output: Contribution to journalArticle

  53. Scaling and crossovers in molecular transport in nano-fluidic systems

    Pimpinelli, A., Ferrari, M. & Grattoni, A., Sep 9 2013, In : Applied Physics Letters. 103, 11, 113104.

    Research output: Contribution to journalArticle

  54. Differential scanning calorimetry as a tool to investigate the transfer of anticancer drugs to biomembrane model

    Sarpietro, M. G., Accolla, M. L., Celia, C., Grattoni, A., Castelli, F., Fresta, M., Ferrari, M. & Paolino, D., Aug 15 2013, In : Current Drug Targets. 14, 9, p. 1053-1060 8 p.

    Research output: Contribution to journalArticle

  55. Validated RP-HPLC method for the simultaneous analysis of gemcitabine and LY-364947 in liposomal formulations

    Bansal, S. S., Celia, C., Ferrati, S., Zabre, E., Ferrari, M., Palapattu, G. & Grattoni, A., Aug 15 2013, In : Current Drug Targets. 14, 9, p. 1061-1069 9 p.

    Research output: Contribution to journalArticle

  56. Silicon Micro- and Nanofabrication for Medicine

    Fine, D., Grattoni, A., Goodall, R., Bansal, S. S., Chiappini, C., Hosali, S., van de Ven, A. L., Srinivasan, S., Liu, X., Godin, B., Brousseau, L., Yazdi, I. K., Fernandez-Moure, J., Tasciotti, E., Wu, H. J., Hu, Y., Klemm, S. & Ferrari, M., May 1 2013, In : Advanced Healthcare Materials. 2, 5, p. 632-666 35 p.

    Research output: Contribution to journalArticle

  57. Characterization of nanochannel delivery membrane systems for the sustained release of resveratrol and atorvastatin: New perspectives on promoting heart health

    Sih, J., Bansal, S. S., Filipini, S., Ferrati, S., Raghuwansi, K., Zabre, E., Nicolov, E., Fine, D., Ferrari, M., Palapattu, G. & Grattoni, A., Jan 1 2013, In : Analytical and Bioanalytical Chemistry. 405, 5, p. 1547-1557 11 p.

    Research output: Contribution to journalArticle

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