Personal profile

Dr. Alessandro Grattoni obtained his bachelors and masters degrees in Mechanical Engineering at the Politecnico of Torino, Turin, Italy in 2005. During his masters degree thesis, he studied the osmotic pressure of non-ideal solutions though nanoporous membranes. This work produced two publications and two patents. A few months after starting graduate school in Biomedical Engineering at Politecnico of Torino in 2006, Alessandro Grattoni joined Dr. Mauro Ferrari’s research team as a visiting student in the Department of Nanomedicine and Biomedical Engineering at the University of Texas Health Science Center at Houston. In this new context, he engaged in the study of transport phenomena in silicon nanofluidic devices for drug delivery.

At the beginning of 2007, he began directing one of the four research platforms, the nanochannel Delivery System (nDS) project. Since then he has coordinated the work of his colleagues in the development and validation of nanochannel membranes for long-term administration of therapeutics from implantable capsules. His research focuses on the experimental and phenomenological analysis of concentration-driven transport in nanoconfinement tools and mathematical models of the nanofluidic system. Additionally he analyzes electrokinetic transport in nanochannels for the purpose of modulating the release of therapeutics from reservoirs. In collaboration with NanoMedical Systems Inc. of Austin, TX, Dr. Grattoni is working to translate innovations in nDS technology to clinical applications.

In April 2009 he was awarded the Heinlein Trust Microgravity Award to support diffusion experiments in microgravity conditions on-board the SpaceX Dragon spacecraft in early 2011. In May 2009 he completed his Ph.D. studies with fifteen peer-reviewed publications and five patent applications. In October 2010, he became an Assistant Member of The Methodist Hospital Research Institute and an Interim Co-Chair of the Nanomedicine Program.

Research interests

Dr. Grattoni's research focuses on the development and clinical translation of implantable nanofluidic technologies for drug delivery, molecular sieving and cell transplantation. Silicon-based nanochannel membranes are developed for the controlled delivery of therapeutics by exploiting nanoscale physics, achieving a constant or tunable sustained release of molecules for extended periods of time. Dr. Grattoni’s research relates to the experimental and theoretical analysis of molecular transport at the nanoscale and the in vivo investigation of long term, sustained delivery of therapeutics. Dr. Grattoni's research has received the support of NASA and State of Texas Emerging Technology Funds, as well as from NanoMedical Systems, Inc.

Keywords

    Research Area Keywords

  • Nanomedicine
  • Immunobiology & Inflammation
  • Cancer
  • Imaging & Radiology

    Free-text keywords

  • Nanomedicine, Nanofluidics, Drug delivery, Silicon technologies, Implantable devices, Space medicine

Fingerprint

Nanofluidics
Concept: Nanofluidics
Weight: 100%
Domain: Engineering & Materials Science
Membranes
Concept: Membranes
Weight: 69%
Domain: Engineering & Materials Science
Drug delivery
Concept: Drug delivery
Weight: 63%
Domain: Engineering & Materials Science
Pharmaceutical Preparations
Concept: Pharmaceutical Preparations
Weight: 50%
Domain: Medicine & Life Sciences
Nanotechnology
Concept: Nanotechnology
Weight: 34%
Domain: Medicine & Life Sciences
Equipment and Supplies
Concept: Equipment and Supplies
Weight: 33%
Domain: Medicine & Life Sciences
Silicon
Concept: Silicon
Weight: 32%
Domain: Medicine & Life Sciences
Therapeutics
Concept: Therapeutics
Weight: 31%
Domain: Medicine & Life Sciences
Encapsulation
Concept: Encapsulation
Weight: 29%
Domain: Engineering & Materials Science
Slip forming
Concept: Slip forming
Weight: 25%
Domain: Chemical Compounds
Research OutputsResearch Output authored by Alessandro Grattoni is tagged with the concept

Journals

Biomedical Microdevices

ISSNs: 1387-2176

Kluwer Academic Publishers

Journal

3

Journal of Physical Chemistry B

ISSNs: 1520-6106, 1089-5647

American Chemical Society

Journal

3

Journal of Controlled Release

ISSNs: 0168-3659

Elsevier

Journal

3

Current Drug Targets

ISSNs: 1389-4501

Bentham Science Publishers Ltd.

Journal

3

Advanced Healthcare Materials

ISSNs: 2192-2640

Additional searchable ISSN (Electronic): 2192-2659

Wiley

Journal

3
has published Research OutputsResearch Output by Alessandro Grattoni

Research Network

Visualization: Institutional Network

Click on a line in the diagram to see collaboration details.

Click icons to see information about the content.

Alessandro Grattoni

Visualization: Co-author Network

Click on a line in the diagram to see collaboration details.

Click icons to see information about the content.

Alessandro Grattoni

Shared Pub. Internal Organizations

Weill Cornell Medical College

Organizational unit: Schools & Hospitals

44

Center for Cardiovascular Regeneration

Organizational unit: Programs

31

Houston Methodist Hospital

Organizational unit: Schools & Hospitals

10
7

J.C. Walter Jr. Transplant Center

Organizational unit: Centers of Excellence

7
has Research OutputsResearch Output by Alessandro Grattoni

Shared Pub. External Organizations

NanoMedical Systems, Inc.

External organization: Unknown

14

Houston Methodist Hospital

External organization: Medical

12

Polytechnic University of Turin

External organization: Academic

10

University of Texas Health Science Center at Houston

External organization: Unknown

10

University of Texas M. D. Anderson Cancer Center

External organization: Academic

5
has Research OutputsResearch Output by Alessandro Grattoni

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Alessandro Grattoni

Shared Pub. External co-authors

Daniel H. Fine

External person

15

Erika Zabre

External person

13

Silvia Ferrati

External person

11

Sharath Hosali

External person

10

Giacomo Bruno

External person

10
has co-authored Research OutputsResearch Output with Alessandro Grattoni

ID: 2287507