• 1286 Citations
  • 21 h-Index
20072020

Research output per year

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Personal profile

Personal profile

Dr. Alessandro Grattoni obtained his bachelors and masters degrees in Mechanical Engineering at the Politecnico of Torino, Turin, Italy in 2005. During his masters degree thesis, he studied the osmotic pressure of non-ideal solutions though nanoporous membranes. This work produced two publications and two patents. A few months after starting graduate school in Biomedical Engineering at Politecnico of Torino in 2006, Alessandro Grattoni joined Dr. Mauro Ferrari’s research team as a visiting student in the Department of Nanomedicine and Biomedical Engineering at the University of Texas Health Science Center at Houston. In this new context, he engaged in the study of transport phenomena in silicon nanofluidic devices for drug delivery.

At the beginning of 2007, he began directing one of the four research platforms, the nanochannel Delivery System (nDS) project. Since then he has coordinated the work of his colleagues in the development and validation of nanochannel membranes for long-term administration of therapeutics from implantable capsules. His research focuses on the experimental and phenomenological analysis of concentration-driven transport in nanoconfinement tools and mathematical models of the nanofluidic system. Additionally he analyzes electrokinetic transport in nanochannels for the purpose of modulating the release of therapeutics from reservoirs. In collaboration with NanoMedical Systems Inc. of Austin, TX, Dr. Grattoni is working to translate innovations in nDS technology to clinical applications.

In April 2009 he was awarded the Heinlein Trust Microgravity Award to support diffusion experiments in microgravity conditions on-board the SpaceX Dragon spacecraft in early 2011. In May 2009 he completed his Ph.D. studies with fifteen peer-reviewed publications and five patent applications. In October 2010, he became an Assistant Member of The Methodist Hospital Research Institute and an Interim Co-Chair of the Nanomedicine Program.

Research interests

Dr. Grattoni's research focuses on the development and clinical translation of implantable nanofluidic technologies for drug delivery, molecular sieving and cell transplantation. Silicon-based nanochannel membranes are developed for the controlled delivery of therapeutics by exploiting nanoscale physics, achieving a constant or tunable sustained release of molecules for extended periods of time. Dr. Grattoni’s research relates to the experimental and theoretical analysis of molecular transport at the nanoscale and the in vivo investigation of long term, sustained delivery of therapeutics. Dr. Grattoni's research has received the support of NASA and State of Texas Emerging Technology Funds, as well as from NanoMedical Systems, Inc.

Education/Academic qualification

Mechanical Engineering, MSc, Politecnico di Torino

Biomedical Engineering, PhD, Politecnico di Torino

Nanomedicine and Biomedical Engineering, Postdoctoral Fellowship, The University of Texas Health Science Center

External positions

Adjunct Professor, Texas A&M University

Aug 2018 → …

Research Area Keywords

  • Nanomedicine
  • Immunobiology & Inflammation
  • Cancer
  • Imaging & Radiology

Free-text keywords

  • Nanomedicine
  • Nanofluidics
  • Drug delivery
  • Silicon technologies
  • Implantable devices
  • Space medicine

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Projects

Research Output

Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery

Di Trani, N., Silvestri, A., Sizovs, A., Wang, Y., Erm, D. R., Demarchi, D., Liu, X. & Grattoni, A., May 7 2020, In : Lab on a Chip. 20, 9, p. 1562-1576 15 p.

Research output: Contribution to journalArticle

  • 2 Scopus citations

    Finite-Size Charged Species Diffusion and pH Change in Nanochannels

    Di Trani, N., Pimpinelli, A. & Grattoni, A., Mar 11 2020, In : ACS Applied Materials and Interfaces. 12, 10, p. 12246-12255 10 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Gold Nanoparticles Radio-Sensitize and Reduce Cell Survival in Lewis Lung Carcinoma

    Pandey, A., Vighetto, V., Di Marzio, N., Ferraro, F., Hirsch, M., Ferrante, N., Mitra, S., Grattoni, A. & Filgueira, C. S., Aug 30 2020, In : Nanomaterials. 10, 9

    Research output: Contribution to journalArticle

  • Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantation

    Paez-Mayorga, J., Capuani, S., Hernandez, N., Farina, M., Chua, Y. X., Blanchard, R., Sizovs, A., Liu, H. C., Fraga, D. W., Niles, J. A., Salazar, H. F., Corradetti, B., Sikora, A. G., Kloc, M., Li, X. C., Gaber, A. O., Nichols, J. & Grattoni, A., Oct 1 2020, In : Biomaterials. 257, 120232.

    Research output: Contribution to journalArticle

  • Preventive efficacy of a tenofovir alafenamide fumarate nanofluidic implant in SHIV-challenged nonhuman primates

    Pons-Faudoa, F. P., Sizovs, A., Shelton, K. A., Momin, Z., Bushman, L. R., Xu, J., Chua, C. Y. X., Nichols, J. E., Hawkins, T., Rooney, J. F., Marzinke, M. A., Kimata, J. T., Anderson, P. L., Nehete, P. N., Arduino, R. C., Ferrari, M., Sastry, K. J. & Grattoni, A., Jan 1 2020, In : bioRxiv. p. 2020.05.13.091694

    Research output: Contribution to journalArticle

  • Prizes

    2019 ISS Compelling Results Award

    Grattoni, Alessandro (Recipient), 2019

    Prize: Other distinction

  • Award for Excellence in Peer Reviewed Publication

    Grattoni, Alessandro (Recipient), 2018

    Prize: Prize (including medals and awards)

    Career Cornerstone Award

    Grattoni, Alessandro (Recipient), 2014

    Prize: Prize (including medals and awards)

    Decoupling Diffusive Transport Phenomena in Microgravity

    Grattoni, Alessandro (Recipient), 2009

    Prize: Prize (including medals and awards)

  • First Place Poster

    Filgueira, Carly S. (Recipient), Stephen R. Igo (Recipient), Brian A. Bruckner (Recipient), Francesca Ferraro (Recipient), Shah, Dipan J. (Recipient), Jerry D. Estep (Recipient) & Grattoni, Alessandro (Recipient), Oct 24 2017

    Prize: Prize (including medals and awards)