Projects per year
Personal profile
Research interests
Tuberculosis (TB) is one of the deadliest infectious diseases, caused by Mycobacterium tuberculosis (Mtb), accounts for more than 1.7 million deaths every year (WHO Report 2023). A characteristic feature of pulmonary tuberculosis is granuloma, which is the collection of immune cells and mesenchymal stem cells (MSCs) surrounding a central core of Mtb-infected macrophages. Granulomas restrict the growth of Mtb and continuously recruit immune and stem cells. Recent reports suggest that although MSCs are not known to interact with microbial pathogens they express Toll-like receptors (TLRs), NOD2 and RIG-I. We found that at a low dose infection Mtb persist in host stem cell for a long term without causing cell death. Interestingly, our preliminary data shows that BCG-infected MSCs reprogrammed naïve macrophages to control Mtb infection. My future research plans are focused on understanding the interaction of MSCs with innate immune cells during the Mtb infection. More specifically, my interest is to seek answers to the following questions,
- Considering the plasticity and self-regulating nature of MSCs, it is important to find out what is the fate of infected MSCs in vivo?
- What are the cellular processes and immune mechanisms that are responsible for the containment of Mtb infection in lung resident MSCs?
- We know that innate immune cells are short lived. The possibility that MSCs could influence innate immune cells in the long-term is through epigenetic modifications. How do MSCs influence the innate immune cells epigenetically?
Based on the inputs from the study my goal is to develop a stem cell-based immunotherapy for TB.
Education/Academic qualification
BSc, Banaras Hindu University
MSc, Goa University
PhD, University of Pune
Research Area Keywords
- Infectious Disease & Pathology
Free-text keywords
- Tuberculosis
- Vaccines
- Macrophage Biology
- Innate immunity
- Autophagy
- Nanotechnology
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Projects
- 1 Active
-
Trained immunity inducing nasal tuberculosis vaccine
Mishra, A. (PI)
10/1/24 → 9/30/25
Project: Federal Funding Agencies
-
Prevention of tuberculosis in cynomolgus macaques by an attenuated Mycobacterium tuberculosis vaccine candidate
Singh, D. K., Ahmed, M., Akter, S., Shivanna, V., Bucşan, A. N., Mishra, A., Golden, N. A., Didier, P. J., Doyle, L. A., Hall-Ursone, S., Roy, C. J., Arora, G., Dick, E. J., Jagannath, C., Mehra, S., Khader, S. A. & Kaushal, D., Dec 2025, In: Nature Communications. 16, 1, 1957.Research output: Contribution to journal › Article › peer-review
-
The pathway of autophagy in the epigenetic landscape of Mycobacterium-host interactions
Mishra, A., Rawat, V., Zhang, K. & Jagannath, C., 2025, (Accepted/In press) In: Autophagy.Research output: Contribution to journal › Review article › peer-review
-
New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis
Zhang, K., Mishra, A. & Jagannath, C., 2024, In: Frontiers in immunology. 15, 1363938.Research output: Contribution to journal › Review article › peer-review
Open Access12 Scopus citations -
The ΔfbpAΔsapM candidate vaccine derived from Mycobacterium tuberculosis H37Rv is markedly immunogenic in macrophages and induces robust immunity to tuberculosis in mice
Mishra, A., Khan, A., Singh, V. K., Glyde, E., Saikolappan, S., Garnica, O., Das, K., Veerapandian, R., Dhandayuthapani, S. & Jagannath, C., 2024, In: Frontiers in immunology. 15, 1321657.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Prospective Subunit Nanovaccine against Mycobacterium tuberculosis Infection─Cubosome Lipid Nanocarriers of Cord Factor, Trehalose 6,6' Dimycolate.
Sarkar, S., Mishra, A., Periasamy, S., Dyett, B., Dogra, P., Ball, A. S., Yeo, L. Y., White, J. F., Wang, Z., Cristini, V., Jagannath, C., Khan, A., Soni, S. K., Drummond, C. J. & Conn, C. E., Jun 14 2023, In: ACS Applied Materials and Interfaces. 15, 23, p. 27670-27686 17 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations