Stanley H. Appel Department of Neurology

2022

Translocator Protein 18 kDa PET Imaging Highlights Asymptomatic Isolated Cerebellar Dysplasia

Pascual, B., Hodics, T., Funk, Q., Cykowski, M. D., Nakawah, M. O. & Masdeu, J. C., Mar 29 2022, In: Neurology. 98, 13, p. 538-539 2 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Tregs Attenuate Peripheral Oxidative Stress and Acute Phase Proteins in ALS

Beers, D. R., Thonhoff, J. R., Faridar, A., Thome, A. D., Zhao, W., Wen, S. & Appel, S. H., Aug 2022, In: Annals of Neurology. 92, 2, p. 195-200 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Tremor rating scales and laboratory tools for assessing tremor

Elble, R. J. & Ondo, W., Apr 15 2022, In: Journal of the Neurological Sciences. 435, 120202.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

Vestibular/Ocular Motor Screening is Independently Associated with Concussion Symptom Severity in Youths

Babicz, M. A., Woods, S. P., Cirino, P., Presley, C., Colton, Z. & Podell, K., Jan 1 2022, In: Clinical Journal of Sport Medicine. 32, 1, p. 40-45 6 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

What does aducanumab treatment of Alzheimer's disease mean for research on vascular cognitive disorders?

Wallin, A., Alladi, S., Black, S. E., Chen, C., Greenberg, S. M., Gustafson, D., Isaacs, J. D., Jokinen, H., Kalaria, R., Mok, V., Pantoni, L., Pasquier, F., Roman, G. C., Rosenberg, G. A., Schmidt, R., Smith, E. E. & Hainsworth, A. H., Jan 2022, In: Cerebral Circulation - Cognition and Behavior. 3, 100044.

Research output: Contribution to journal › Editorial › peer-review

Open Access

3 Scopus citations

2021

AbobotulinumtoxinA provides flexibility for the treatment of cervical dystonia with 500 U/1 mL and 500 U/2 mL dilutions

Lew, M. F., Hauser, R. A., Isaacson, S. H., Truong, D., Patel, A. T., Brashear, A., Ondo, W., Maisonobe, P., Dashtipour, K., Bahroo, L. & Wietek, S., Jan 2021, In: Clinical Parkinsonism and Related Disorders. 5, p. 100115 100115.

Research output: Contribution to journal › Article › peer-review

Open Access

A brief diagnostic screen for cluster headache: Creation and initial validation of the Erwin Test for Cluster Headache

Parakramaweera, R., Evans, R. W., Schor, L. I., Pearson, S. M., Martinez, R., Cammarata, J. S., Amin, A. J., Yoo, S. H., Zhang, W., Yan, Y. & Burish, M. J., Nov 2021, In: Cephalalgia. 41, 13, p. 1298-1309 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage

Sadaf, H., Desai, V. R., Misra, V., Golanov, E., Hegde, M. L., Villapol, S., Karmonik, C., Regnier-Golanov, A., Sayenko, D., Horner, P. J., Krencik, R., Weng, Y. L., Vahidy, F. S. & Britz, G. W., Nov 2021, In: Annals of Clinical and Translational Neurology. 8, 11, p. 2211-2221 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Scopus citations

Acute Transverse Myelitis (ATM):Clinical Review of 43 Patients With COVID-19-Associated ATM and 3 Post-Vaccination ATM Serious Adverse Events With the ChAdOx1 nCoV-19 Vaccine (AZD1222)

Román, G. C., Gracia, F., Torres, A., Palacios, A., Gracia, K. & Harris, D., Apr 26 2021, In: Frontiers in immunology. 12, p. 653786 653786.

Research output: Contribution to journal › Article › peer-review

Open Access

125 Scopus citations

Alterations to the gut microbiome after sport-related concussion and subconcussive impacts in a collegiate football players cohort

Soriano, S., Curry, K., Sadrameli, S. S., Qi "Maria", W., Nute, M., Reeves, E., Kabir, R., Wiese, J. R., Criswell, A., Schodrof, S., Britz, G. W., Gadhia, R. R., Podell, K., Treangen, T. & Villapol, S., 2021, (Unpublished) In: medRxiv.

Research output: Contribution to journal › Article

A Multi-center Genome-wide Association Study of Cervical Dystonia

Sun, Y. V., Li, C., Hui, Q., Huang, Y., Barbano, R., Rodriguez, R., Malaty, I. A., Reich, S., Bambarger, K., Holmes, K., Jankovic, J., Patel, N. J., Roze, E., Vidailhet, M., Berman, B. D., LeDoux, M. S., Espay, A. J., Agarwal, P., Pirio-Richardson, S., Frank, S. A., & 35 othersOndo, W. G., Saunders-Pullman, R., Chouinard, S., Natividad, S., Berardelli, A., Pantelyat, A. Y., Brashear, A., Fox, S. H., Kasten, M., Krämer, U. M., Neis, M., Bäumer, T., Loens, S., Borsche, M., Zittel, S., Maurer, A., Gelderblom, M., Volkmann, J., Odorfer, T., Kühn, A. A., Borngräber, F., König, I. R., Cruchaga, C., Cotton, A. C., Kilic-Berkmen, G., Freeman, A., Factor, S. A., Scorr, L., Bremner, J. D., Vaccarino, V., Quyyumi, A. A., Klein, C., Perlmutter, J. S., Lohmann, K. & Jinnah, H. A., Dec 2021, In: Movement Disorders. 36, 12, p. 2795-2801 7 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Amyotrophic lateral sclerosis is a systemic disease: peripheral contributions to inflammation-mediated neurodegeneration

Appel, S. H., Beers, D. R. & Zhao, W., Oct 1 2021, In: Current opinion in neurology. 34, 5, p. 765-772 8 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study

Alzheimer’s Disease Genetics Consortium, Sep 15 2021, In: Acta Neuropathologica Communications. 9, 1, p. 152 152.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

An Intelligent Augmented Lifelike Avatar App for Virtual Physical Examination of Suspected Strokes

Yao, K., Wong, K. K., Yu, X., Volpi, J. & Wong, S. T. C., Nov 1 2021, In: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2021, p. 1727-1730 4 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

An Intelligent Augmented Lifelike Avatar App for Virtual Physical Examination of Suspected Strokes

Yao, K., Wong, K. K., Yu, X., Volpi, J. & Wong, S. T. C., 2021, 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021. Institute of Electrical and Electronics Engineers Inc., p. 1727-1730 4 p. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Ankyrin-r regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K⁺ channels

Stevens, S. R., Longley, C. M., Ogawa, Y., Teliska, L. H., Arumanayagam, A. S., Nair, S., Oses-Prieto, J. A., Burlingame, A. L., Cykowski, M. D., Xue, M. & Rasband, M. N., Jun 2021, In: eLife. 10, e66491.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

A Phase 2 Proof-of-Concept, Randomized, Placebo-Controlled Trial of CX-8998 in Essential Tremor

Papapetropoulos, S., Lee, M. S., Versavel, S., Newbold, E., Jinnah, H. A., Pahwa, R., Lyons, K. E., Elble, R., Ondo, W., Zesiewicz, T., Hedera, P., Handforth, A., Elder, J. & Versavel, M., Aug 2021, In: Movement Disorders. 36, 8, p. 1944-1949 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Approaches to Understanding COVID-19 and its Neurological Associations

on behalf of the Global COVID-19 Neuro Research Coalition, Jun 2021, In: Annals of Neurology. 89, 6, p. 1059-1067 9 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Author Correction: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation (Nature Biomedical Engineering, (2020), 4, 1, (69-83), 10.1038/s41551-019-0485-1)

Yang, Z., Shi, J., Xie, J., Wang, Y., Sun, J., Liu, T., Zhao, Y., Zhao, X., Wang, X., Ma, Y., Malkoc, V., Chiang, C., Deng, W., Chen, Y., Fu, Y., Kwak, K. J., Fan, Y., Kang, C., Yin, C., Rhee, J., & 9 othersBertani, P., Otero, J., Lu, W., Yun, K., Lee, A. S., Jiang, W., Teng, L., Kim, B. Y. S. & Lee, L. J., Aug 2021, In: Nature Biomedical Engineering. 5, 8, p. 944-945 2 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

4 Scopus citations

Beneficial effects of transplanted human bone marrow endothelial progenitors on functional and cellular components of blood-spinal cord barrier in ALSMice

Garbuzova-Davis, S., Boccio, K. J., Llauget, A., Shell, R., Hailu, S., Mustafa, H., Ehrhart, J., Sanberg, P. R., Appel, S. H. & Borlongan, C. V., Sep 1 2021, In: eNeuro. 8, 5, ENEURO.0314-21.2021.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Brain arteriolosclerosis

Blevins, B. L., Vinters, H. V., Love, S., Wilcock, D. M., Grinberg, L. T., Schneider, J. A., Kalaria, R. N., Katsumata, Y., Gold, B. T., Wang, D. J. J., Ma, S. J., Shade, L. M. P., Fardo, D. W., Hartz, A. M. S., Jicha, G. A., Nelson, K. B., Magaki, S. D., Schmitt, F. A., Teylan, M. A., Ighodaro, E. T., & 5 othersPhe, P., Abner, E. L., Cykowski, M. D., Van Eldik, L. J. & Nelson, P. T., Jan 2021, In: Acta Neuropathologica. 141, 1

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

CCG•CGG interruptions in high-penetrance SCA8 families increase RAN translation and protein toxicity

Perez, B. A., Shorrock, H. K., Banez-Coronel, M., Zu, T., Romano, L. E. L., Laboissonniere, L. A., Reid, T., Ikeda, Y., Reddy, K., Gomez, C. M., Bird, T., Ashizawa, T., Schut, L. J., Brusco, A., Berglund, J. A., Hasholt, L. F., Nielsen, J. E., Subramony, S. H. & Ranum, L. P. W., Nov 8 2021, In: EMBO Molecular Medicine. 13, 11, e14095.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Clinical and genomic analysis of a large Chinese family with familial cortical myoclonic tremor with epilepsy and SAMD12 intronic repeat expansion

Zhou, Y., Sood, R., Wang, Q., Carrington, B., Park, M., Young, A. C., Birnbaum, D., Liu, Z., Ashizawa, T., Mullikin, J. C., Koubeissi, M. Z. & Liu, P., Mar 2021, In: Epilepsia Open. 6, 1, p. 102-111 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Clinical features of new daily persistent headache: A retrospective chart review of 328 cases

Evans, R. W. & Turner, D. P., Nov 1 2021, In: Headache. 61, 10, p. 1529-1538 10 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Clinical phenotype and mutation spectrum of alzheimer’s disease with causative genetic mutation in a chinese cohort

Mao, C., Li, J., Dong, L., Huang, X., Lei, D., Wang, J., Chu, S., Liu, C., Peng, B., Román, G. C., Cui, L. & Gao, J., 2021, In: Current Alzheimer Research. 18, 3, p. 265-272 8 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Consensus Guidelines on Rodent Models of Restless Legs Syndrome

International Restless Legs Syndrome Study Group (IRLSSG), Mar 2021, In: Movement Disorders. 36, 3, p. 558-569 12 p.

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Covid-19: Neurological sequelae

Spencer, P. S., Román, G., Buguet, A., Guekht, A. & Reis, J., 2021, In: Health Risk Analysis. 2021, 2, p. 165-172 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Detection of endothelial cell-associated human DNA reveals transplanted human bone marrow stem cell engraftment into CNS capillaries of ALS mice

Garbuzova-Davis, S., Boccio, K. J., Ehrhart, J., Sanberg, P. R., Appel, S. H. & Borlongan, C. V., May 2021, In: Brain Research Bulletin. 170, p. 22-28 7 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Development of standardized regression-based formulas to assess meaningful cognitive change in early Parkinson's disease

Combs, H. L., Wyman-Chick, K. A., Erickson, L. O. & York, M. K., Aug 1 2021, In: Archives of Clinical Neuropsychology. 36, 5, p. 734-745 12 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases

Zhang, N., Bewick, B., Schultz, J., Tiwari, A., Krencik, R., Zhang, A., Adachi, K., Xia, G., Yun, K., Sarkar, P. & Ashizawa, T., Jul 2021, In: Neurotherapeutics. 18, 3, p. 1710-1728 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Dystonia and Tremor: A Cross-Sectional Study of the Dystonia Coalition Cohort

Shaikh, A. G., Beylergil, S. B., Scorr, L., Kilic-Berkmen, G., Freeman, A., Klein, C., Junker, J., Loens, S., Brüggemann, N., Münchau, A., Bäumer, T., Vidailhet, M., Roze, E., Bonnet, C., Jankovic, J., Jimenez-Shahed, J., Patel, N., Marsh, L., Comella, C., Barbano, R. L., & 23 othersBerman, B. D., Malaty, I., Wagle Shukla, A., Reich, S. G., Ledoux, M. S., Berardelli, A., Ferrazzano, G., Stover, N., Ondo, W., Pirio Richardson, S., Saunders-Pullman, R., Mari, Z., Agarwal, P., Adler, C., Chouinard, S., Fox, S. H., Brashear, A., Truong, D., Suchowersky, O., Frank, S., Factor, S., Perlmutter, J. & Jinnah, H. A., Jan 26 2021, In: Neurology. 96, 4, p. E563-E574

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Environmental neurology in the tropics

Reis, J., Spencer, P. S., Román, G. C. & Buguet, A., Feb 15 2021, In: Journal of the Neurological Sciences. 421, 117287.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Erratum: Sustained functional benefits after a single set of injections with abobotulinumtoxinA using a 2-mL injection volume in adults with cervical dystonia: 12- week results from a randomized, doubleblind, placebo-controlled phase 3b study (PLoS ONE (2021) 16:2 (e0245827) DOI: 10.1371/journal.pone.0245827)

Patel, A. T., Lew, M. F., Dashtipour, K., Isaacson, S., Hauser, R. A., Ondo, W., Maisonobe, P., Wietek, S., Rubin, B. & Brashear, A., Apr 2021, In: PLoS ONE. 16, 4 April, e0250475.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson’s disease

Thome, A. D., Atassi, F., Wang, J., Faridar, A., Zhao, W., Thonhoff, J. R., Beers, D. R., Lai, E. C. & Appel, S. H., Dec 2021, In: npj Parkinson's Disease. 7, 1, 41.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Fast progression in amyotrophic lateral sclerosis is associated with greater tdp-43 burden in spinal cord

Cathcart, S. J., Appel, S. H., Peterson, L. E., Greene, E. P., Powell, S. Z., Arumanayagam, A. S., Rivera, A. L. & Cykowski, M. D., Aug 1 2021, In: Journal of Neuropathology and Experimental Neurology. 80, 8, p. 754-763 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Generalized Periodic Discharges With Triphasic Morphology in the Setting of Aztreonam Neurotoxicity

Billnitzer, A. & Kaplan, P. W., Jan 2021, In: Clinical EEG and Neuroscience. 52, 1, p. 66-68 3 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease

Alzheimer's Disease Neuroimaging Initiative, Dec 1 2021, In: Nature Communications. 12, 1, 4001.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Homonymous hemianopsia as a reversible manifestation of normal-pressure hydrocephalus

Zehden, J., Raviskanthan, S., Bhat, N., Mortensen, P. W., Román, G. C. & Lee, A. G., Dec 2021, In: Canadian Journal of Ophthalmology. 56, 6, p. e182-e185

Research output: Contribution to journal › Letter › peer-review

Open Access

How did individual differences in neurocognition and health literacy influence the initial uptake and use of health-related information about COVID-19?

Babicz, M. A., Woods, S. P., Matchanova, A., Medina, L. D., Podell, K., Walker, R. L., Fetterman, A., Rahman, S., Johnson, B., Thompson, J. L., Sullivan, K. L., Beltran-Najera, I., Brooks, J., Morales, Y. & Avci, G., Jul 2021, In: Journal of Clinical and Experimental Neuropsychology. 43, 5, p. 497-513 17 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Huntingtin Maintains Mitochondrial Genome Integrity and Function

Pradhan, S., Gao, R., Bush, K., Zhang, N., Smith-Geater, C., Chakraborty, A., Morozko, E., Dickey, A., Yuan, S., Snowden, J., Sikdar, N., Choudhary, S., Keene, C., Ellerby, L., Ashizawa, T., Hazra, T., La Spada, A., Wairkar, Y., Thompson, L. & Sarkar, P., Jun 18 2021, In: SSRN Electronic Journal. 71 p.

Research output: Contribution to journal › Article › peer-review

Idiopathic Intracranial Hypertension and Anemia: A Matched Case-Control Study: Response

Lin, W. V., Berry, S. E., Nakawah, M. O., Sadaka, A. & Lee, A. G., Jun 1 2021, In: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 41, 2, p. e273-e274

Research output: Contribution to journal › Letter › peer-review

Imaging spectrum of adverse events of immune checkpoint inhibitors

Shroff, G. S., Shroff, S., Ahuja, J., Truong, M. T. & Vlahos, I., Apr 2021, In: Clinical Radiology. 76, 4, p. 262-272 11 p.

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Incidence, predictors, and outcomes of post-thrombectomy seizures in the extended time window

Agashe, S., Hooper, D., Nisar, T., McCane, D., Lee, J., Chyuan Ling, K., S.Vahidy, F., Chiu, D. & Gadhia, R. R., Jan 2021, In: Epilepsy and Behavior Reports. 15, 100426.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

In vitro and pilot in vivo imaging of 18 kDa translocator protein (TSPO) in inflammatory vascular disease

Schollhammer, R., Lepreux, S., Barthe, N., Vimont, D., Rullier, A., Sibon, I., Berard, X., Zhang, A., Kimura, Y., Fujita, M., Innis, R. B., Zanotti-Fregonara, P. & Morgat, C., 2021, In: EJNMMI Research. 11, 1, 45.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

LambdaUNet: 2.5D Stroke Lesion Segmentation of Diffusion-Weighted MR Images

Ou, Y., Yuan, Y., Huang, X., Wong, K., Volpi, J., Wang, J. Z. & Wong, S. T. C., 2021, Medical Image Computing and Computer Assisted Intervention – MICCAI 2021 - 24th International Conference, Proceedings. de Bruijne, M., de Bruijne, M., Cattin, P. C., Cotin, S., Padoy, N., Speidel, S., Zheng, Y. & Essert, C. (eds.). Springer Science and Business Media Deutschland GmbH, p. 731-741 11 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 12901 LNCS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Latent structure of a brief clinical battery of Neuropsychological tests administered in-home via telephone

Matchanova, A., Babicz, M. A., Medina, L. D., Rahman, S., Johnson, B., Thompson, J. L., Beltran-Najera, I., Brooks, J., Sullivan, K. L., Walker, R. L., Podell, K. & Woods, S. P., Sep 1 2021, In: Archives of Clinical Neuropsychology. 36, 6, p. 874-886 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access