Houston Methodist

Projects

Projects per year 2000 2016 2018 2019 2020 2021 2022 2023 2024 2046

• 193 Not started
• 541 Active
• 826 Finished

Projects per year

Search results

• Active

  Tregs in AD clinical trial A Phase II Clinical Trial of Interleukin-2 (IL-2) in Patients with Mild to Moderate Alzheimer's Disease Progress

  Faridar, A. (PI), Masdeu, J. C. (Key Personnel) & Pascual, B. (Key Personnel)

  9/9/21 → …

  Project: Clinical Trial

• ER stress response and chronic lymphocytic leukemia

  Hu, C.-C. A. (PI), Pingali, S. R. (Key Personnel) & Tang, C.-H. A. (Key Personnel)

  9/3/21 → …

  Project: Clinical Trial

• SARS-CoV-2 and Precursors of Alzheimer Disease and Related Dementias: An Ultrahigh Field (7T) MRI Study in a Diverse Multinational Cohort

  Roman, G. C. (PI), Vahidy, F. S. (PI) & Masdeu, J. C. (Key Personnel)

  9/1/21 → 8/31/25

  Project: Federal Funding Agencies

• Chemoprevention of lung cancer by targeting lonidamine to mitochondria

  You, M. (PI), Wang, Y. (Key Personnel) & Zhang, Q. (Key Personnel)

  9/1/21 → 8/31/25

  Project: Federal Funding Agencies

• CAPTIVA- Comparison of Anti-coagulation and anti-Platelet Therapies for Intracranial Vascular Atherostenosis

  Chiu, D. (PI)

  9/1/21 → 8/31/26

  Project: Federal Funding Agencies

• Dynamics of Colonization and Infection by Multidrug-resistant Pathogens in Immunocompromised and Critically Ill Patients (DYNAMITE)

  Arias, C. A. (PI)

  9/1/21 → 7/31/26

  Project: Federal Funding Agencies

• Longitudinal multi-center head-to-head harmonization of tau PET tracers

  Pascual, B. (PI)

  9/1/21 → 5/31/25

  Project: Federal Funding Agencies

• CPRIT Scholar Application - Rising Star - Yong Lu

  Lu, Y. (PI)

  8/31/21 → 8/30/26

  Project: State

• Contemporary Classification of Myocardial Injury Events in MESA: Defining Distinct Risk Factor Associations with Myocardial Infarction Type 1-5 and Acute Non-Ischemic Myocardial Injury.

  Nasir, K. (PI)

  8/20/21 → 7/31/26

  Project: Federal Funding Agencies

• Phase 3_Sotatercept_ Pulmonary Arterial Hypertension _Acceleron A011-12 SOTERIA A Long-term Follow-up Study of Sotatercept for PAH Treatment

  Safdar, Z. (PI) & Syed, M. U. (Key Personnel)

  8/5/21 → …

  Project: Clinical Trial

• Regulatory T cells as a novel therapeutic target in Alzheimer's Disease

  Appel, S. H. (PI), Faridar, A. (PI) & Masdeu, J. C. (PI)

  8/1/21 → 6/30/25

  Project: Non Profit

• Prevascularized encapsulation platform with local immunosuppression for Islet transplantation

  Gaber, A. O. (PI) & Grattoni, A. (PI)

  8/1/21 → 7/31/25

  Project: Non Profit

• A novel tool in high- dimensional single-cell space to predict neurotoxicity of CAR T cell therapies

  Lu, Y. (PI)

  8/1/21 → 7/31/26

  Project: Federal Funding Agencies

• Fulvestrant Plus Abemaciclib With or Without Run-In of Fulvestrant in Er-Positive, Her2-Negative Metastatic Breast Cancer

  Chang, J. C. (PI), Heyne, K. (Key Personnel), Mai, H. P. (Key Personnel), Mathur, S. (Key Personnel), Niravath, P. A. (Key Personnel) & Sun, K. (Key Personnel)

  7/15/21 → …

  Project: Clinical Trial

• NeoSoma Neuro-oncology AI Platform

  Fung, S. H. (PI) & Baskin, D. S. (Key Personnel)

  7/7/21 → …

  Project: Clinical Trial

• A PHASE 3, MULTICENTER, RANDOMIZED, OPEN-LABEL, ACTIVE-CONTROLLED STUDY OF TRASTUZUMAB DERUXTECAN (T-DXd) VERSUS TRASTUZUMAB EMTANSINE (T-DM1) IN SUBJECTS WITH HIGH-RISK HER2-POSITIVE PRIMARY BREAST CANCER WHO HAVE RESIDUAL INVASIVE DISEASE IN BREAST OR

  7/6/21 → 7/5/31

  Project: Non Profit

• Targeting the HIV-1 Reservoir in Myeloid Cells

  Wang, J. (PI) & Li, M. (Key Personnel)

  7/6/21 → 5/31/26

  Project: Federal Funding Agencies

• Understanding the mechanisms that regulate cytoplasmic capping and defining itscontributions to post-transcriptional gene regulation (Same as parent grant)

  Kiss, D. L. (PI)

  7/1/21 → 6/30/25

  Project: Federal Funding Agencies

• HEALEY ALS Platform Trial - Regimen-Specific Appendix D - For pridopidine 45 mg oral capsule administered twice daily (BID) or its matching placebo.

  Appel, S. H. (PI), Shroff, S. (PI), Greene, E. P. (CoI) & Liao, B. (CoI)

  6/29/21 → 7/23/25

  Project: Non Profit

• Long-Term, Observational, Registry of Patients With Generalized Myasthenia Gravis Who Have Received Treatment With Complement C5 Inhibition Therapies

  Greene, E. P. (PI), Liao, B. (Key Personnel) & Shroff, S. (Key Personnel)

  6/28/21 → …

  Project: Clinical Trial

• MitraClip REPAIR MR Study

  Goel, S. (PI), Bhimaraj, A. (Key Personnel), Faza, N. (Key Personnel), Kassi, M. (Key Personnel), Kleiman, N. (Key Personnel), Lawrie, G. M. (Key Personnel), Little, S. H. (Key Personnel), Reardon, M. J. (Key Personnel) & Yousefzai, R. (Key Personnel)

  6/28/21 → …

  Project: Clinical Trial

• AOCT - Intuitive da Vinci SP in Colorectal Surgical Procedures

  6/28/21 → …

  Project: Clinical Trial

• Studies of a new checkpoint regulator in the control of intestinal inflammation

  Zhang, Z. (PI) & Li, X. C. (Key Personnel)

  6/7/21 → 5/31/26

  Project: Federal Funding Agencies

• Molecular Mechanism of Virulence Regulation in Streptococcus Pyogenes

  Kumaraswami, M. (PI) & Olsen, R. J. (Key Personnel)

  6/7/21 → 5/31/26

  Project: Federal Funding Agencies

• A Phase III Clinical Trial Evaluating De-Escalation of Breast Radiation for Conservative Treatment of Stage I, Hormone Sensitive, HER2-Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

  6/7/21 → 2/28/25

  Project: Non Profit

• Novel Stem Cell Immunotherapy for MDR-Tuberculosis

  Jagannath, C. (PI)

  6/4/21 → 5/31/26

  Project: Federal Funding Agencies

• Houston Alzheimer Disease Study

  Masdeu, J. C. (PI), Faridar, A. (Key Personnel), Karmonik, C. (Key Personnel), Nakawah, M. O. (Key Personnel), Pascual, B. (Key Personnel), Roman, G. C. (Key Personnel), Toledo, J. B. (Key Personnel) & Wong, S. T. (Key Personnel)

  5/17/21 → …

  Project: Clinical Trial

• Systematic modeling and prediction of cell-type-specific and spatiotemporal crosstalk pathways in Alzheimer¿s Disease

  Wong, S. T. (PI), Sheng, J. (Key Personnel) & Yin, Z. (Key Personnel)

  5/15/21 → 4/30/26

  Project: Federal Funding Agencies

• CVL-751-PD-004 (TEMPO-1 TRIAL)

  Ondo, W. G. (PI) & Waln, O. (Key Personnel)

  5/11/21 → …

  Project: Clinical Trial

• Determinants of COVID19-induced venous thrombosis and targeted therapy assessed with bioengineered Vein-Chip.

  Cooke, J. P. (PI)

  5/1/21 → 4/30/25

  Project: Federal Funding Agencies

• Upper Extremity Nerve Transfers in Spinal Cord Injury Patients

  Faraji, A. (PI)

  5/1/21 → 9/29/25

  Project: Federal Funding Agencies

• Amplatzer Amulet LAAO vs. NOAC (CATALYST)

  Valderrábano, M. (PI), Dave, A. (Key Personnel), Goel, S. (Key Personnel), Lador, A. (Key Personnel), Mathuria, N. (Key Personnel) & Schurmann, P. A. (Key Personnel)

  4/19/21 → …

  Project: Clinical Trial

• A Phase II and Biomarker Study of Dual VEGF/PD-L1 Blockade in Neoadjuvant Setting in Resectable Hepatocellular Carcinoma Patients

  Ghobrial, R. M. (PI), Abdelrahim, M. (Key Personnel) & Kodali, S. (Key Personnel)

  4/1/21 → 3/31/26

  Project: Federal Funding Agencies

• TB/MDR-TB research Capacity Building in LMIC in Southeast Asia

  Graviss, E. A. (PI)

  4/1/21 → 2/28/25

  Project: Federal Funding Agencies

• Targeting ER stress response in B-cell chronic lymphocytic leukemia

  Hu, C.-C. A. (PI), Pingali, S. R. (Key Personnel) & Tang, C.-H. A. (Key Personnel)

  4/1/21 → 3/31/25

  Project: Federal Funding Agencies

• S100A4 mediated immune suppression in GBM

  Yun, K. (PI) & Xu, S. (Key Personnel)

  4/1/21 → 1/31/26

  Project: Federal Funding Agencies

• RE-ENERGIZE FONTAN - RandomizEd Exercise INtERvention desiGned to MaximIZE Fitness in Pediatric FONTAN patients

  Cooke, J. P. (PI)

  3/26/21 → 2/28/25

  Project: Federal Funding Agencies

• An Open-Label Randomized Active-Controlled Phase II Clinical Study to Assess the Efficacy and Safety of Afuresertib Plus Paclitaxel Versus Paclitaxel in Patients with Platinum-ResistantOvarian Cancer

  Kamat, A. A. (PI), Darcourt, J. (CoI), Singh, M. (CoI), Suri, A. (CoI) & Zaid, T. (CoI)

  3/15/21 → 3/14/46

  Project: Non Profit

• A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)

  Toledo, J. B. (PI), Faridar, A. (Key Personnel), Masdeu, J. C. (Key Personnel), Nakawah, M. O. (Key Personnel) & Pascual, B. (Key Personnel)

  3/12/21 → …

  Project: Clinical Trial

• CHEST CYTOSTORM study

  Gotur, D. B. (PI)

  3/8/21 → …

  Project: Clinical Trial

• Nanoparticle delivery of miRNA-based therapeutics to overcome clinical challenges in triple negative breast cancer

  Wang, Z. (PI) & Cristini, V. (Key Personnel)

  3/4/21 → 2/28/26

  Project: Federal Funding Agencies

• Nanotechnology-based targeting of breast cancer liver metastases

  Godin, B. (PI), Chen, S.-H. (Key Personnel), Niravath, P. A. (Key Personnel), Rosato, R. R. (Key Personnel) & Xu, S. (Key Personnel)

  3/1/21 → 2/28/25

  Project: Federal Funding Agencies

• Multicenter Phase I/Ib Trial of Olaparib in Combination With Vorinostat in Patients With Relapsed/Refractory and/or Metastatic Breast Cancer

  Chang, J. C. (PI), Mai, H. P. (Key Personnel), Niravath, P. A. (Key Personnel) & Sun, K. (Key Personnel)

  2/9/21 → …

  Project: Clinical Trial

• Elucidate the effect of biophysical properties evolution in sentinel lymph node of breast cancer on initiating lung metastasis using novel ultrasound poroelastography

  Liu, X. (PI)

  2/1/21 → 1/31/25

  Project: Federal Funding Agencies

• The use of mobile health technology to improve breast and prostate cancer survivors' health behaviors in managing their weight and lifestyle

  Stubbins, R. E. (PI), Niravath, P. A. (Key Personnel), Satkunasivam, R. (Key Personnel) & Wong, S. T. (Key Personnel)

  1/25/21 → …

  Project: Clinical Trial

• Transplant Research Biobank

  Gaber, A. O. (PI), Bernard, D. W. (Key Personnel), Ghobrial, R. M. (Key Personnel), Rizk, E. (Key Personnel), Singh, R. (Key Personnel) & Uosef, A. (Key Personnel)

  1/20/21 → …

  Project: Clinical Trial

• PARALLEL PHASE III RANDOMIZED TRIALS FOR HIGH RISK PROSTATE CANCER EVALUATING DE-INTENSIFICATION FOR LOWER GENOMIC RISK AND INTENSIFICATION OF CONCURRENT THERAPY FOR HIGHER GENOMIC RISK WITH RADIATION (PREDICT-RT*)

  Haque, W. M. (PI)

  12/15/20 → 2/28/25

  Project: Non Profit

• N/A

  Dacha, S. (PI) & Quigley, E. M. (Key Personnel)

  12/2/20 → …

  Project: Clinical Trial

• MRI Guided PAD Imaging

  Roy, T. (PI), Karmonik, C. (Key Personnel), Lumsden, A. B. (Key Personnel) & Peden, E. K. (Key Personnel)

  11/19/20 → …

  Project: Clinical Trial

• Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of AL001 in FTD (AL001-3) (INFRONT-3)

  Masdeu, J. C. (PI), Faridar, A. (Key Personnel), Pascual, B. (Key Personnel) & Toledo, J. B. (Key Personnel)

  10/20/20 → …

  Project: Clinical Trial